📰 GPCR Weekly News, January 1 to 7, 2024

Hello readers! The newest GPCR research is hot off the press! We’ve curated 18 GPCR papers, 8 industry news, and 2 GPCR job offers!

This week's highlights:

• Congratulations to Drs. Inês Pinheiro and Oliver Hartley from the Orion Biotechnology team on their recent study on Arylsulfatases and neuraminidases!

• Congratulations to Domain Therapeutics for appointing Michael Gottlieb as Chairman and Dr. Anthony Johnson as President/CEO!

Save the dates:

February 8 - 29: Join Dr. GPCR University's live Zoom sessions hosted by Dr. Terry Kenakin. The course covers basic pharmacology in four weekly segments. Only ten spots remain. Registrations are open to everyone (you will need to become a free site member) and end on February 1st, 2024! Hurry and secure your spot today! The cost is $299 and includes:

• All 4 live Zoom sessions ( 4x 1 hour lecture + 30 mins Q&A)

• 30-minute one-on-one meeting with Dr. Kenakin, according to his availability

• Access to the cohort’s Dr. GPCR Ecosystem group, where you can find Dr. Kenakin and your classmates

• Access to the course materials and recordings

• Course completion certificate signed by Dr. Kenakin and Dr. GPCR

• Complimentary one-year Dr. GPCR Ecosystem Premium memberships, a $250 saving

• Access to Dr. GPCR Ecosystem contents and perks, including our forums, private groups, and all Ecosystem members

Go to Dr. GPCR University and save your spot today! 

Let’s dive into the Classified GPCR News from January 1st to 7th, 2024.

Adhesion GPCRs

• The adhesion G-protein-coupled receptor mayo/CG11318 controls midgut development in Drosophila

• Structure, ligands, and roles of GPR126/ADGRG6 in the development and diseases

GPCR Activation and Signaling

• Proinflammatory chemokine CXCL14 activates MAS-related G protein-coupled receptor MRGPRX2 and its putative mouse ortholog MRGPRB2

• Metabolite-sensing GPCRs in rheumatoid arthritis

• Dissecting the molecular basis for the modulation of neurotransmitter GPCR signaling by GINIP

• Molecular mechanism of antihistamines recognition and regulation of the histamine H1 receptor

• [Enhancement of mast cells activation by ATP via P2X4 receptor]

• Osmotic stress studies of G-protein-coupled receptor rhodopsin activation

GPCR Binders, Drugs, and more

• Chimeric antigens displaying GPR65 extracellular loops on a soluble scaffold enabled the discovery of antibodies, which recognized native receptor

• Targeting class A GPCRs for hard tissue regeneration

GPCRs in Neuroscience

• Astrocyte growth is driven by the Tre1/S1pr1 phospholipid-binding G protein-coupled receptor

Methods & Updates in GPCR Research

• RediscMol: Benchmarking Molecular Generation Models in Biological Properties

• Characterization of the real-time internalization of nine GPCRs reveals distinct dependence on arrestins and G proteins

• A method for structure determination of GPCRs in various states

Reviews, GPCRs, and more

• G Protein-coupled Receptors (GPCRs) as Potential Therapeutics for Psychiatric Disorders

Structural and Molecular Insights into GPCR Function

• Apelin Receptor Dimerization and Oligomerization

• The role of leucine and isoleucine in tuning the hydropathy of class A GPCRs

• Arylsulfatases and neuraminidases modulate engagement of CCR5 by chemokines by removing key electrostatic interactions

Industry News

• Domain Therapeutics strengthens leadership team to spearhead global development and North American expansion as the leading GPCR immuno-oncology company

• Sosei Group Announces Appointment of Experienced Pharmaceutical Executive Toshihiro Maeda as Chief Operating Officer

• Rhythm Pharmaceuticals and LG Chem Life Sciences Enter Agreement for Rhythm to Acquire Global Rights to Oral MC4R Agonist LB54640

• Addex to Present at Biotech Showcase™ 2024

• Establishing our first international translational research project - Institute for Protein Design

• Generate:Biomedicines Fortifies Leadership in Generative AI with Advancing Clinical Pipeline and Expanded Amgen Collaboration, Overviewed at the 42nd Annual J.P. Morgan Healthcare Conference

• Isomorphic Labs Announces Strategic Multi-Target Research Collaboration With Novartis

• Salipro Biotech announces multi-target research collaboration with an additional Top5 crop protection company  

GPCR Events, Meetings, and Webinars

• January 16 - 19, 2024 | 23rd Annual PEP Talk

• February 3 - 7, 2024 | SLAS2024 International Conference and Exhibition

• February 11 - 14, 2024 | 2024 BPS Annual Meeting

• March 5 - 7, 2024 | 3rd GPCRs - Targeted Drug Discovery Summit

• March 23 - 24, 2024 | Ligand Recognition and Molecular Gating Seminar

• March 24 - 29, 2024 | Ligand Recognition and Molecular Gating Conference

• April 1 - 4, 2024 | 19th Annual Drug Discovery Chemistry

• April 4 - 7, 2024 | American Physiology Summit

• April 5 - 10, 2024 | AACR Annual Meeting

• April 22 - 23, 2024 | Endocrine Metabolic GPCRs

• May 13 - 17, 2024 | 20th Annual PEGS Boston Summit

• May 16 - 19, 2024 | ASPET 2024

• May 27 - 29, 2024 | SLAS Europe 2024 Conference and Exhibition

• June 2 - 7, 2024 | Chemotactic Cytokines

• June 9 - 14, 2024 | 2024 Phosphorylation and G-Protein Mediated Signaling Networks

• June 25 - 29, 2024 | FENS Forum 2024

• October 2 - 4, 2024 | 9th GPCRs in Medicinal Chemistry

•  October 23 - 25, 2024 | 11th Adhesion GPCR Workshop

• July 12 - 17, 2026 | 20th World Congress of Basic and Clinical Pharmacology 2026

GPCR Jobs

• NEW Postdoctoral Fellow

• NEW Research Laboratory Specialist Associate

• Postdoctoral Scientist

• Principal Investigator, In Vitro Biology

• Associate Scientist

• Postdoctoral Scholar - O’Neill Lab

• Junior Research Scientist

• Postdoctoral Fellow  

Explore Dr. GPCR Ecosystem