📰 GPCR Weekly News, January 15 to 21, 2024

Hello readers! Check out our curated GPCR coverage for this week, which includes 14 GPCR papers, four industry news, one GPCR Event, and two GPCR job ads!

This week's highlight:

• Dr. Graham Ladds’ team refines AlphaFold models using binding calculations for human adenosine A3 receptor.

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Dr. GPCR University

Our first Dr. GPCR University course, Applying Pharmacology to Drug Discovery, led by Dr. Terry Kenakin, starts February 8th, 2024.

Due to popular demand, we have opened additional spots. If you'd like to join colleagues and Dr. Kenakin in a small group setting, hurry and register today. Only three spots remain. The course covers basic pharmacology in four weekly segments and is open to all with a free site membership. The cost is USD $299 and includes:

• Four live Zoom sessions (1 hour lecture + 30 mins Q&A each)

• A 30-minute one-on-one meeting with Dr. Kenakin

• Access to the cohort’s Dr. GPCR Ecosystem group

• Access to course materials and recordings

• A course completion certificate signed by Dr. Kenakin and Dr. GPCR

• Complimentary one-year Dr. GPCR Ecosystem Premium memberships (a $250 saving)

• Access to Dr. GPCR Ecosystem contents and perks
  

Go to Dr. GPCR University and secure your spot before registration ends on February 1, 2024.

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Dr. GPCR Partnered Events

• March 5 - 7, 2024 | 3rd GPCRs - Targeted Drug Discovery Summit  We're partnering again with the 3rd GPCRs - Targeted Drug Discovery Summit in Boston on March 5-7, 2024. Dr. GPCR Members get 10% off with code MPDRGPCR10 at checkout. Don't miss out!
  

• April 22 - 23, 2024 | Endocrine Metabolic GPCRs  Join Dr. GPCR at the Endocrine Metabolic GPCRs Summit on April 22-23, 2024, in Birmingham, UK. Dr. GPCR Ecosystem Members get a 5% discount with code GPCRDR5 at checkout until Feb 2nd, 2024. Hurry and don't miss out!

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Let’s dive into the Classified GPCR News from January 15th to 21st, 2024

Adhesion GPCRs

• The adhesion GPCR GPR116/ADGRF5 has a dual function in pancreatic islets regulating somatostatin release and islet development

GPCR Activation and Signaling

• In Vitro Module Editing Of NRPS Enables Production Of Highly Potent Gq-Signaling Inhibitor FR900359 Derived From Unculturable Plant Symbiont

• Systematic assessment of chemokine ligand bias at the human chemokine receptor CXCR2 indicates G protein bias over β-arrestin recruitment and receptor internalization

• Class VI G protein-coupled receptors in Aspergillus oryzae regulate sclerotia formation through GTPase-activating activity

• A cholesterol switch controls phospholipid scrambling by G protein-coupled receptors

• Decoding anaphylatoxins: unveiling the molecular mechanisms of complement receptor activation and signaling

GPCR Binders, Drugs, and more

• Computational Workflow for Refining AlphaFold Models in Drug Design Using Kinetic and Thermodynamic Binding Calculations: A Case Study for the Unresolved Inactive Human Adenosine A3 Receptor

GPCRs in Cardiology, Endocrinology, and Taste

• Hepatic Regulator of G protein Signaling 14 Ameliorates NAFLD through Activating cAMP-AMPK Signaling by Targeting Giα1/3

• APOL1-mediated monovalent cation transport contributes to APOL1-mediated podocytopathy in kidney disease

• Hepatocyte GPCR signaling regulates IRF3 to control hepatic stellate cell transdifferentiation

GPCRs in Oncology and Immunology

• The orphan G protein-coupled receptor 141 expressed in myeloid cells functions as an inflammation suppressor

Methods & Updates in GPCR Research

• G-Protein Coupled Receptor Gpr-1 Is Important for the Growth and Nutritional Metabolism of an Invasive Bark Beetle Symbiont Fungi Leptographium procerum

• Editorial: Advanced biophysical and biochemical technologies to study GPCR signal transduction

Structural and Molecular Insights into GPCR Function

• Segregation of nascent GPCRs in the ER-to-Golgi transport by CCHCR1 via direct interaction

Industry News

• Novartis Lutathera® significantly reduced risk of disease progression or death by 72% as first-line treatment for patients with advanced gastroenteropancreatic neuroendocrine tumors

• Neurocrine Biosciences Announces Conference Call and Webcast of Fourth Quarter and Year-End 2023 Financial Results

• St. Jude Children’s Research Hospital adds $13 million project to Research Collaboratives Program

• AIRSUPRA® (albuterol/budesonide) now available as the first and only FDA-approved anti-inflammatory rescue option for asthma  
  

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GPCR Events, Meetings, and Webinars

• January 16 - 19, 2024 | 23rd Annual PEP Talk

• February 3 - 7, 2024 | SLAS2024 International Conference and Exhibition

• February 11 - 14, 2024 | 2024 BPS Annual Meeting

• NEW March 13 - 15 | 9th German Pharm-Tox Summit 

• March 23 - 24, 2024 | Ligand Recognition and Molecular Gating Seminar

• March 24 - 29, 2024 | Ligand Recognition and Molecular Gating Conference

• April 1 - 4, 2024 | 19th Annual Drug Discovery Chemistry

• April 4 - 7, 2024 | American Physiology Summit

• April 5 - 10, 2024 | AACR Annual Meeting

• May 13 - 17, 2024 | 20th Annual PEGS Boston Summit

• May 16 - 19, 2024 | ASPET 2024

• May 27 - 29, 2024 | SLAS Europe 2024 Conference and Exhibition

• June 2 - 7, 2024 | Chemotactic Cytokines

• June 9 - 14, 2024 | 2024 Phosphorylation and G-Protein Mediated Signaling Networks

• June 25 - 29, 2024 | FENS Forum 2024

• October 2 - 4, 2024 | 9th GPCRs in Medicinal Chemistry

•  October 23 - 25, 2024 | 11th Adhesion GPCR Workshop

• July 12 - 17, 2026 | 20th World Congress of Basic and Clinical Pharmacology 2026

GPCR Jobs

• NEW Post-Doc position

• NEW Lead Researcher

• Senior Researcher in Structural Biology

• Post-Doctoral Fellow

• Postdoctoral Fellow

• Research Laboratory Specialist Associate

• Postdoctoral Scientist

• Principal Investigator, In Vitro Biology  

Join Dr. GPCR Ecosystem