📰 GPCR Weekly News, January 22 to 28, 2024

Hello readers! Look at our curated GPCR coverage for this week, which includes 10 GPCR papers, seven industry news, and 2 GPCR events!

This week's highlight:

• Congrats to Dr. Xavier Leroy on his appointment as CEO of GIO Therapeutics!

• Congratulations to Domain Therapeutics for being awarded the RHU SPRINT consortium grant.

• Erratum: In the past week's newsletter, the highlighted article should have read “Drs. Margarita Stampelou, Graham Ladds, and Antonios Kolocouris refine AlphaFold models using binding calculations for human adenosine A3 receptor. “

---

Dr. GPCR Symposia

Our first upcoming symposium on March 15th this year is about GPCR activation and signaling. Confirmed speakers include Drs. Franziska Heydenreich, Sudarshan Rajagopal, Graham Ladds, and Michel Bouvier

We will also have a poster session at each event on Zoom this year. Please email us at Hello@DrGPCR.com if you want to share your work with our community.

Did you participate in our Symposia in 2023? Take 2 minutes to fill out this survey and let us know what you liked, what you didn’t, and what we can do better.

Dr. GPCR University

We're thrilled to share that all spots for the Applying Pharmacology to Drug Discovery course by Dr. GPCR University have been filled! Thank you for the overwhelming response.

If you're still keen on joining this course but missed out on registration, don't worry; we've opened a waitlist. We appreciate your enthusiasm and interest in advancing your knowledge with us. We look forward to having you on board for future courses coming soon!

Please fill out the waitlist form. We'll let you know if any spots become available.

---

Dr. GPCR Volunteers

Join our dynamic team as a volunteer! We’ll send your contributor articles to our community, keep you updated with GPCR papers, receive support and network with GPCR specialists at our events, and a free Premium Membership. Only 4 hours per month are required. If you are interested in applying, please email us your CV/Resume at  Hello@DrGPCR.com.

Dr. GPCR Partnered Events

• 3rd GPCRs - Targeted Drug Discovery Summit  Join us at the 3rd GPCRs Targeted Drug Discovery Summit in Boston on March 5-7, 2024. Dr. GPCR Members get 10% off with code MPDRGPCR10.

• Endocrine Metabolic GPCRs  Join the Endocrine Metabolic GPCRs event in Birmingham, UK, on April 22-23, 2024. Dr. GPCR members get a 5% discount with code GPCRDR5 until Feb 2nd, 2024.

Let’s dive into the Classified GPCR News from January 22nd to 28th, 2024

GPCR Activation and Signaling

• Optical Control of Adenosine A2A Receptor Using Istradefylline Photosensitivity

• Comparative interactome analysis of α-arrestin families in human and Drosophila

• Functional diversification of cell signaling by GPCR localization

GPCR Binders, Drugs, and more

• Decrypting orphan GPCR drug discovery via multitask learning

GPCRs in Cardiology, Endocrinology, and Taste

• The Role of Gut Microbiota and Associated Compounds in Cardiovascular Health and its Therapeutic Implications

• The perspective of cAMP/cGMP signaling and cyclic nucleotide phosphodiesterases in aortic aneurysm and dissection

GPCRs in Oncology and Immunology

• Molecular docking and dynamics simulation studies uncover the host-pathogen protein-protein interactions in Penaeus vannamei and Vibrio parahaemolyticus

• Involvement of Protease-Activated Receptor2 Pleckstrin Homology Binding Domain in Ovarian Cancer: Expression in Fallopian Tubes and Drug Design

Structural and Molecular Insights into GPCR Function

• Optimizing cryo-EM structural analysis of Gi-coupling receptors via engineered Gt and Nb35 application

• Imaging GPCR Dimerization in Living Cells with Cucurbit[7]uril and Hemicyanine as a "Turn-On" Fluorescence Probe

Industry News

• Domain Therapeutics awarded Hospital-University Research in Health (RHU) SPRINT consortium grant to progress its proprietary CCR8 antibody candidate to the clinic

• Novo strikes another obesity drug deal

• Sosei Heptares Webinar Presentation for FY2023 Financial Results

• Novartis Automates New Radioligand Therapy Production Plant

• Novartis’ Lutathera reduces disease progression risk in GEP-NET trial 

• Novo Nordisk hits $500 billion in market value as it flags soaring demand for Wegovy, Ozempic 

• Dr. Xavier Leroy appointed as CEO of GIO Therapeutics 

GPCR Events, Meetings, and Webinars

• NOW! February 1 | GPCR Forum ECI 

• February 3 - 7, 2024 | SLAS2024 International Conference and Exhibition

• February 11 - 14, 2024 | 2024 BPS Annual Meeting

• NEW February 20, 2024 | Career Opportunities in Pharmacology and Drug Discovery

• March 13 - 15 | 9th German Pharm-Tox Summit 

• March 23 - 24, 2024 | Ligand Recognition and Molecular Gating Seminar

• March 24 - 29, 2024 | Ligand Recognition and Molecular Gating Conference

• April 1 - 4, 2024 | 19th Annual Drug Discovery Chemistry

• April 4 - 7, 2024 | American Physiology Summit

• April 5 - 10, 2024 | AACR Annual Meeting

• May 13 - 17, 2024 | 20th Annual PEGS Boston Summit

• May 16 - 19, 2024 | ASPET 2024

• May 27 - 29, 2024 | SLAS Europe 2024 Conference and Exhibition

• June 2 - 7, 2024 | Chemotactic Cytokines

• June 9 - 14, 2024 | 2024 Phosphorylation and G-Protein Mediated Signaling Networks

• June 25 - 29, 2024 | FENS Forum 2024

• October 2 - 4, 2024 | 9th GPCRs in Medicinal Chemistry

•  October 23 - 25, 2024 | 11th Adhesion GPCR Workshop

• July 12 - 17, 2026 | 20th World Congress of Basic and Clinical Pharmacology 2026

GPCR Jobs

• Post-Doc position

• Lead Researcher

• Senior Researcher in Structural Biology

• Post-Doctoral Fellow

• Postdoctoral Fellow

• Research Laboratory Specialist Associate

Join Dr. GPCR Ecosystem