📰 GPCR Weekly News, January 23 to 29, 2023

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Below is your Classified GPCR News at a glance for January 23rd to the 29th, 2023.

GPCR Activation and Signaling

• A multi-dimensional view of context-dependent G protein-coupled receptor function.

• The role of intracellular calcium and Rho kinase pathways in G protein-coupled receptor-mediated contractions of urinary bladder urothelium and lamina propria.

• Soluble cyclase-mediated nuclear cAMP synthesis is sufficient for cell proliferation.

• Molecular Modeling Study of a Receptor-Orthosteric Ligand-Allosteric Modulator Signaling Complex.

GPCR Binders, Drugs, and more

• MRAP2 regulates energy homeostasis by promoting primary cilia localization of MC4R.

• Design, synthesis, and evaluation of substituted alkylindoles that activate G protein-coupled receptors distinct from the cannabinoid CB1 and CB2 receptors.

Methods & Updates in GPCR Research

• Development and Characterization of a Highly Selective Turn-On Fluorescent Ligand for β3-Adrenergic Receptor.

• GPCR Signaling Measurement and Drug Profiling with an Automated Live-Cell Microscopy System.

• Generation of Gαi knock-out HEK293 cells illuminates Gαi-coupling diversity of GPCRs.

Reviews, GPCRs, and more

• Pharmacological Profiling of a Brugia malayi Muscarinic Acetylcholine Receptor as a Putative Antiparasitic Target.

Structural and Molecular Insights into GPCR Function

• Structural and dynamic insights into supra-physiological activation and allosteric modulation of a muscarinic acetylcholine receptor.

• Structural Understanding of Peptide-Bound G Protein-Coupled Receptors: Peptide-Target Interactions.

• Structural and Molecular Determinants for Isoform Bias at Human Histamine H3 Receptor Isoforms.

Industry News

• Inversago Pharma to Participate at the 2023 SVB Securities Global BioPharma Conference

• Orbit Discovery and Endevica Bio enter multi-target collaboration to advance development of cachexia therapeutics

• Sosei Heptares Webinar Presentation for FY2022 Financial Results

Call for GPCR Papers

• GPCRs: Signal Transduction. Deadline February 12, 2023

GPCR Events, Meetings, and Webinars

• 2nd GPCR-Targeted Drug Discovery Summit, (February 21 - 23, 2023), Boston.

• SLAS2023 International Conference and Exhibition (February 25 - March 1, 2023).

• 2nd ERNEST Training School. (February 20 - March 3, 2023).

• GEM2023. (March 14-17, 2023).

• SLAS 2023 Building Biology in 3D Symposium. (April 20 - 21, 2023)

• SLAS Europe 2023 Conference and Exhibition. (May 22 - 26, 2023)

• 2nd LEAPS Meets Life Sciences Conference. (May 14 - 19, 2023)

• 8th and final ERNEST Meeting in Crete. (May 3 - 7, 2023).

• The Illuminating the Understudied Druggable Proteome Conference. (June 4 - 8, 2023).

• 2023 Molecular Pharmacology (GRS) Seminar GRC. (June 10 - 11, 2023).

• Progressive Technologies and Approaches Revealing Novel GPCR Biology and Drug Development Potential. (June 11 - 16, 2023).

• 19th World Congress of Basic & Clinical Pharmacology 2023. (July 2 - 7, 2023).

GPCR Jobs

• Scientist/Senior Scientist (Research Software Engineer)

• Senior Scientist – Native Mass Spectrometry

• Speculative Applications (Protein Biochemistry)

• Speculative Applications (Mass Spectrometry)

• Speculative Applications (Chemistry)

• Post-Doctoral Research Assistant

• Research Fellow - School of Physics and Astronomy

• Postdoctoral Research Associate (Fixed Term)

• PhD Project - Investigating the lipid regulation of GPCR signalling

• Postdoctoral Fellow - Molecular Dynamics

• Postdoc in lipid regulation of GPCRs

• Postdoctoral positions, biophysics of transporters and GPCRs

• Chief of Staff

• Postdoctoral Fellow, Biochemical And Cellular Pharmacology

• Project Leader, Biology

Explore Dr. GPCR Ecosystem