📰 GPCR Weekly News, January 29 to February 4, 2024

Hello readers! Check out our GPCR coverage for this week. We have 21 GPCR papers, three industry news, and two job ads.

This week's highlight includes congrats to:

• Gabriele Kockelkoren, Dr. Dimitrios Stamou, et al. for their work on the Molecular mechanism of GPCR spatial organization at the plasma membrane, featured on the cover of Nature Chemical Biology

• Julia Kinsolving; Dr. Gunnar Schulte et al. on the study of the interaction of Clostridioides difficile toxin B and FZD7.

• Preston Nibley, Dr. Sudha K Shenoy et al. on their work entitled β-arrestins and their potential role in heart failure.

• Dr. Xavier Leroy for his new role as CEO of GIO Therapeutics

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Dr. GPCR Symposia

Our upcoming symposium on March 15th is about GPCR activation and signaling. Confirmed speakers include Drs. Franziska Heydenreich, Sudarshan Rajagopal, Graham Ladds, and Michel Bouvier. 

We will also have a poster session in breakout rooms on Zoom; if you are interested in sharing your work with our community, kindly fill out this form. Additionally, if you participated in our Symposia in 2023, please take a moment to fill out this survey.

Dr. GPCR University

This week marks the beginning of our first Dr.GPCR University course, 'Applying Pharmacology to Drug Discovery,' which will be led by Dr. Terry Kenakin.

If you are interested in joining this course but missed the registration window, don't worry! You can sign up for our waitlist. We are considering rerunning this live course later this year. If you are on the waitlist, you'll be the first notified, and you'll be able to register for the course official registrations open.

Dr. GPCR Volunteers

Join our dynamic team as a volunteer! You'll share your contributor articles with the community, stay updated with GPCR literature, join a dynamic team, network with GPCR scientists at our events, and get a complimentary Premium Membership with only 4 hours/monthly commitment on your part.

If you are interested in applying, please email us your CV/Resume at  Hello@DrGPCR.com.

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Dr. GPCR Partnered Events

• March 5 - 7, 2024 | 3rd GPCRs - Targeted Drug Discovery Summit Join us at the 3rd GPCRs Summit in Boston on March 5-7, 2024. Dr. GPCR Members get 10% off with code MPDRGPCR10.

• April 22 - 23, 2024 | Endocrine Metabolic GPCRs Join the Endocrine Metabolic GPCRs event in Birmingham, UK, on April 22-23, 2024. 

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Let’s dive into the Classified GPCR News from January 29th to February 4th, 2024

Adhesion GPCRs

• CELSR1, a core planar cell polarity protein, features a weakly adhesive and flexible cadherin ectodomain

GPCR Activation and Signaling

• GPCR signaling bias: an emerging framework for opioid drug development

• Structural and functional insight into the interaction of Clostridioides difficile toxin B and FZD7

• Loss-of-function of GNAL dystonia gene impairs striatal dopamine receptors-mediated adenylyl cyclase/ cyclic AMP signaling pathway

• The non-nutritive sweetener sucralose increases β-arrestin signaling at the constitutively active orphan G protein-coupled receptor GPR52

• Endosome positioning coordinates spatially selective GPCR signaling

• GRK5 promoted renal fibrosis via HDAC5/Smad3 signaling pathway

• Non-canonical G protein signaling

GPCR Binders, Drugs, and more

• Insights on discovery, efficacy, safety and clinical applications of ghrelin receptor agonist capromorelin in veterinary medicine

GPCRs in Cardiology, Endocrinology, and Taste

• The role of P2Y6 receptor in the pathogenesis of cardiovascular and inflammatory diseases

• β-adrenergic receptor signaling mediated by β-arrestins and its potential role in heart failure

GPCRs in Neuroscience

• Role of lipids in the control of autophagy and primary cilium signaling in neurons

• The structure and function of olfactory receptors

GPCRs in Oncology and Immunology

• Natural carboxyterminal truncation of human CXCL10 attenuates glycosaminoglycan binding, CXCR3A signaling and lymphocyte chemotaxis, while retaining angiostatic activity

• GPR68-ATF4 signaling is a novel prosurvival pathway in glioblastoma activated by acidic extracellular microenvironment

• Drosophila cytokine GBP2 exerts immune responses and regulates GBP1 expression through GPCR receptor Mthl10

Methods & Updates in GPCR Research

• Engineering, applications, and future perspectives of GPCR-based genetically encoded fluorescent indicators for neuromodulators

• Illuminating the brain-genetically encoded single wavelength fluorescent biosensors to unravel neurotransmitter dynamics

• MFD-GDrug: multimodal feature fusion-based deep learning for GPCR-drug interaction prediction

Structural and Molecular Insights into GPCR Function

• Structural insights into membrane adenylyl cyclases, initiators of cAMP signaling

• Molecular mechanism of GPCR spatial organization at the plasma membrane

Industry News

• Launch of GIO Therapeutics, founded by Cumulus Oncology, to develop therapeutics targeting G protein-coupled receptors to treat cancer and inflammation

• AVROBIO and Tectonic Therapeutic Announce Merger

• Trevena Inc Elevates Barry Shin to Executive VP and CFO

GPCR Events, Meetings, and Webinars

• February 11 - 14, 2024 | 2024 BPS Annual Meeting

• February 20, 2024 | Career Opportunities in Pharmacology and Drug Discovery

• March 13 - 15 | 9th German Pharm-Tox Summit 

• March 23 - 24, 2024 | Ligand Recognition and Molecular Gating Seminar

• March 24 - 29, 2024 | Ligand Recognition and Molecular Gating Conference

• April 1 - 4, 2024 | 19th Annual Drug Discovery Chemistry

• April 4 - 7, 2024 | American Physiology Summit

• April 5 - 10, 2024 | AACR Annual Meeting

• May 13 - 17, 2024 | 20th Annual PEGS Boston Summit

• May 16 - 19, 2024 | ASPET 2024

• May 27 - 29, 2024 | SLAS Europe 2024 Conference and Exhibition

• June 2 - 7, 2024 | Chemotactic Cytokines

• June 9 - 14, 2024 | 2024 Phosphorylation and G-Protein Mediated Signaling Networks

• June 25 - 29, 2024 | FENS Forum 2024

• October 2 - 4, 2024 | 9th GPCRs in Medicinal Chemistry

•  October 23 - 25, 2024 | 11th Adhesion GPCR Workshop

• July 12 - 17, 2026 | 20th World Congress of Basic and Clinical Pharmacology 2026

GPCR Jobs

• NEW Postdoctoral Fellowship- Mechanistic Biology 

• NEW Research Scientist

• Post-Doc position

• Lead Researcher

• Senior Researcher in Structural Biology

• Post-Doctoral Fellow

Join Dr. GPCR Ecosystem