📰 GPCR Weekly News, January 8 to 14, 2024

Hi readers! Dive into our GPCR coverage for this week! We’ve curated 10 GPCR papers, seven industry news, and two GPCR job ads!

This week's highlight:

• Dr. Kathleen M Caron and her team studied the GPER/GPR30 complex with β1-adrenergic receptor and AKAP5 in MCF7 breast cancer cells.
  

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Dr. GPCR University

February 8 - 29: Join Dr. GPCR University's live course with Dr. Terry Kenakin. The course covers basic pharmacology in four weekly segments. Registrations are open to everyone (you will need to become a free site member) and end on February 1st, 2024! Hurry and secure your spot today! The cost is $299 and includes:

• All 4 live Zoom sessions ( 4x 1 hour lecture + 30 mins Q&A)

• 30-minute one-on-one meeting with Dr. Kenakin, according to his availability

• Access to the cohort’s Dr. GPCR Ecosystem group, where you can find Dr. Kenakin and your classmates

• Access to the course materials and recordings 

• Course completion certificate signed by Dr. Kenakin and Dr. GPCR

• Complimentary one-year Dr. GPCR Ecosystem Premium memberships,  a $250 saving

• Access to Dr. GPCR Ecosystem contents and perks, including our forums, private groups, and all Ecosystem members

Only 9 Spots Remain!! Go to Dr. GPCR University and save your spot today! 

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Dr. GPCR Partnered Events

• March 5 - 7, 2024 | 3rd GPCRs - Targeted Drug Discovery Summit Exciting news! We're partnering again with the 3rd GPCRs - Targeted Drug Discovery Summit in Boston on March 5-7, 2024. Dr. GPCR Members get 10% off with code MPDRGPCR10 at checkout. Don't miss out!

• April 22 - 23, 2024 | Endocrine Metabolic GPCRs Join us at the Endocrine Metabolic GPCRs event on April 22-23, 2024 in Birmingham, UK. Dr. GPCR members get a 5% discount with code GPCRDR5 at checkout until Feb 2nd, 2024. Hurry and don't miss out!

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Let’s dive into the Classified GPCR News from January 8th to 14th, 2024

Adhesion GPCRs

• Conformational transitions and activation of the adhesion receptor CD97

GPCR Activation and Signaling

• Biased Signaling in Mutated Variants of β2-Adrenergic Receptor: Insights from Molecular Dynamics Simulations

GPCRs in Cardiology, Endocrinology, and Taste

• Propionate functions as a feeding-state-dependent regulatory metabolite to counter pro-inflammatory signaling linked to nutrient load and obesity

GPCRs in Neuroscience

• The Na+ leak channel NALCN controls spontaneous activity and mediates synaptic modulation by α2-adrenergic receptors in auditory neurons

GPCRs in Oncology and Immunology

• G protein-coupled estrogen receptor (GPER)/GPR30 forms a complex with the β1-adrenergic receptor, a membrane-associated guanylate kinase (MAGUK) scaffold protein, and protein kinase A anchoring protein (AKAP) 5 in MCF7 breast cancer cells

Reviews, GPCRs, and more

• The multifaceted functions of β-arrestins and their therapeutic potential in neurodegenerative diseases

• The progress of small molecules against cannabinoid 2 receptor (CB2R)

• Ketone bodies as chemical signals for the immune system

• AI-driven GPCR analysis, engineering, and targeting

Structural and Molecular Insights into GPCR Function

• Characterizing conformational states in GPCR structures using machine learning

Industry News

• Exscientia Unveils MolFlux: Empowering the ML Community in Molecular Predictive Modelling 

• NanoImaging Services Appoints John Rigg as Chief Executive Officer

• Unraveling GPCRs Conformations: A Leap in Drug Discovery with STAGS Machine Learning Model

• Three GPCR Companies Earn Prestigious Best Places to Work Certification in 2023 

• Orion Biotechnology will be presenting at the OBIO 2024 Investment Summit

• X-rays to AlphaFold: the future structure of drug discovery

• Aelis Farma Achieves Milestone: Randomisation Concludes in Largest-Ever Phase 2b Clinical Trial for Cannabis Addiction Treatment AEF0117 
  

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GPCR Events, Meetings, and Webinars

• January 16 - 19, 2024 | 23rd Annual PEP Talk

• February 3 - 7, 2024 | SLAS2024 International Conference and Exhibition

• February 11 - 14, 2024 | 2024 BPS Annual Meeting

• March 23 - 24, 2024 | Ligand Recognition and Molecular Gating Seminar

• March 24 - 29, 2024 | Ligand Recognition and Molecular Gating Conference

• April 1 - 4, 2024 | 19th Annual Drug Discovery Chemistry

• April 4 - 7, 2024 | American Physiology Summit

• April 5 - 10, 2024 | AACR Annual Meeting

• May 13 - 17, 2024 | 20th Annual PEGS Boston Summit

• May 16 - 19, 2024 | ASPET 2024

• May 27 - 29, 2024 | SLAS Europe 2024 Conference and Exhibition

• June 2 - 7, 2024 | Chemotactic Cytokines

• June 9 - 14, 2024 | 2024 Phosphorylation and G-Protein Mediated Signaling Networks

• June 25 - 29, 2024 | FENS Forum 2024

• October 2 - 4, 2024 | 9th GPCRs in Medicinal Chemistry

•  October 23 - 25, 2024 | 11th Adhesion GPCR Workshop

• July 12 - 17, 2026 | 20th World Congress of Basic and Clinical Pharmacology 2026

GPCR Jobs

• NEW Senior Researcher in Structural Biology

• NEW Post-Doctoral Fellow

• Postdoctoral Fellow

• Research Laboratory Specialist Associate

• Postdoctoral Scientist

• Principal Investigator, In Vitro Biology

• Associate Scientist

• Postdoctoral Scholar - O’Neill Lab
  

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