📰 GPCR Weekly News - January 9 to 15, 2023

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Below is your Classified GPCR News at a glance for January 9th to January 15th, 2023.

GPCR Activation and Signaling

• New simulation insights on the structural transition mechanism of Bovine Rhodopsin activation.

• Mandibulofacial dysostosis with alopecia results from gain-of-ETAR function via allosteric effects on ligand binding.

GPCR Binders, Drugs, and more

• Modelling altered signalling of G-protein coupled receptors in inflamed environment to advance drug design.

• Protease-activated receptor 2 (PAR2)-targeting peptide derivatives for positron emission tomography (PET) imaging.

GPCRs in Cardiology, Endocrinology, and Taste

• Gender Differences in GRK2 in Cardiovascular Diseases and its Interactions with Estrogen.

• GPR97 deficiency ameliorates renal interstitial fibrosis in mouse hypertensive nephropathy.

Reviews, GPCRs, and more

• Isolation and functional identification of secretin family G-protein coupled receptor from Y-organ of the mud crab, Scylla olivacea.

Structural and Molecular Insights into GPCR Function

• Thermodynamic architecture and conformational plasticity of GPCRs.

• Structural Understanding of Peptide-Bound G Protein-Coupled Receptors: Peptide-Target Interactions.

• Cryo-EM structures of orphan GPR21 signaling complexes.

• GPCR Allostery: a View from Computational Biology.

• The molecular associations in clathrin-coated pit regulate β-arrestin-mediated MAPK signaling downstream of μ-opioid receptor.

Industry News

• Trevena Enrolls First Subject in TRV045 Proof-of-Concept Trial Evaluating S1PR Mechanism of Action and Target Engagement

• Novo Nordisk's GLP-1 for Type II diabetes approved for first-line treatment

• The Lundbeck Foundation is awarding DKK 174 million in grants to seven ‘mind-bending’ research collaborations

• GPCR Therapeutics Announces Launch of US Phase 2 Trial of GPC-100 in Multiple Myeloma

Call for GPCR Papers

• GPCRs: Signal Transduction. Deadline February 12, 2023

• Current Technologies To Understand G-Protein-Coupled Receptor Molecular Pharmacology. Deadline January 30, 2023.

GPCR Events, Meetings, and Webinars

• 2nd GPCR-Targeted Drug Discovery Summit | February 21-23, Boston.

• SLAS2023 International Conference and Exhibition (February 25 - March 1).

• SLAS 2023 Building Biology in 3D Symposium. (April 20-21, 2023)

• SLAS Europe 2023 Conference and Exhibition. (May 22 - 26, 2023)

• 2nd ERNEST Training School. (February 20 - March 3, 2023).

• GEM2023. (March 14-17, 2023).

• 8th and final ERNEST Meeting in Crete. (May 3-7, 2023).

• The Illuminating the Understudied Druggable Proteome Conference. (June 4-8, 2023).

• 2023 Molecular Pharmacology (GRS) Seminar GRC. (June 10 -11, 2023).

• Progressive Technologies and Approaches Revealing Novel GPCR Biology and Drug Development Potential. (June 11-16, 2023).

• 19th World Congress of Basic & Clinical Pharmacology 2023. (July 2 - 7).

GPCR Jobs

• Biotechnology and Biological Sciences Doctoral Training Programme

• Senior QM Manager

• Director of Molecular Pharmacology, Discovery Biology

• Staff Scientist/Senior Staff Scientist, Disease Biology and Translational Sciences

• Senior Scientist, Drug Metabolism and Pharmacokinetics

• PhD Opportunity - Investigation Of The Role Of The Formyl Peptide Receptor 2 In Diabetic Retinopathy

• PhD Opportunity - Novel P2y Receptor Ligands For Drug Discovery

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