📰 GPCR Weekly News, July 17 to July 23, 2023

Welcome, GPCR fellows! Get ready for the latest GPCR news. This week's highlighted papers:

• Dr. Bryan Roth's work on "Built-in functional selectivity in neurons is mediated by the neuronal protein, GINIP."

• Dr. Antony Boucard's research on "Biased Signaling is Structurally Encoded As An Autoproteolysis Event in Adhesion G Protein-Coupled Receptor Latrophilin-3/ADGRL3."

• Gabriele Kockelkoren's contribution as first-author on "Molecular mechanism of GPCR spatial organization at the plasma membrane."

Our Dr. GPCR Symposium on Structural and Molecular Insights on GPCR Activation was a success! Thank you to the speakers and attendees. If you missed it, don't worry. Premium members can always go back and watch the recorded talks at any time.

Mark your calendars for the upcoming Dr. GPCR Symposium on GPCRs as Therapeutic Modalities on September 22nd. Interested in chatting about your work in an informal setting? Submit a 1-minute abstract video and tell us more about your project in this form. Stay updated by subscribing to Dr. GPCR Newsletter!

Don't forget to check out the weekly Classified GPCR News from July 17th to July 23rd, 2023.

Adhesion GPCRs

• Biased Signaling is Structurally Encoded As An Autoproteolysis Event in Adhesion G Protein-Coupled Receptor Latrophilin-3/ADGRL3.

• mthl1, a potential Drosophila homologue of mammalian adhesion GPCRs, is involved in antitumor reactions to injected oncogenic cells in flies.

GPCR Activation and Signaling

• Atypical Chemokine Receptor 3 'Senses' CXC Chemokine Receptor 4 Activation Through GPCR Kinase Phosphorylation.

GPCRs in Cardiology, Endocrinology, and Taste

• Cardiac contraction and relaxation are regulated by distinct subcellular cAMP pools.

GPCRs in Neuroscience

• Mu-opioid receptor selective superagonists produce prolonged respiratory depression.

• Olanzapine manipulates neuroactive signals and may onset metabolic disturbances.

• A corazonin G protein-coupled receptor gene in the tick Ixodes scapularis yields two splice variants, each coding for a specific corazonin receptor.

GPCRs in Oncology and Immunology

• A GPCR checkpoint drives CD8+ T cell dysfunction and immunotherapy failure in mice.

Methods & Updates in GPCR Research

• Fluorescent Ligands Enable Target Engagement Studies for the Intracellular Allosteric Binding Site of the Chemokine Receptor CXCR2.

• GPCRome-wide analysis of G-protein-coupling diversity using a computational biology approach.

Reviews, GPCRs, and more

• Interplay of thermodynamics and evolution within the ternary ligand-GPCR-G protein complex.

• Built-in functional selectivity in neurons is mediated by the neuronal protein, GINIP.

Structural and Molecular Insights into GPCR Function

• Molecular mechanism of GPCR spatial organization at the plasma membrane.

Industry News

• Exscientia Initiates Prospective Observational Study in Ovarian Cancer.

• Domain Therapeutics announces the European Patent Office decision to grant a patent for its proprietary immuno-oncology EP4 receptor antagonist program including DT-9081.

• Sosei Heptares Acquires Idorsia’s Pharmaceuticals Business in Japan and APAC (ex-China), Accelerating its Transformation into a Fully Integrated Biopharmaceutical Company.

• Addex Mglu2pam Demonstrates Potential In Substance Use Disorder.

• Orion Biotechnology Completes Discovery of First-in-Class Molecule Against Undrugged GPCR Target in Four Months

• Cumulus Oncology and Leadxpro collaborate on small molecules targeting cancer-focused GPCR.

GPCR Events, Meetings, and Webinars

• NEW Summer GPCR Zoominar session (July 27, 2023).

• ONCORNET2.0 Final Symposium (August 31 - September 1, 2023) Registration ends Tomorrow!

• Discovery On Target (September 25 - 28, 2023)

• 3rd Annual Meeting IRN I-GPCRNet (October 25 - 27, 2023)

• GPCR Retreat (November 2 - 4, 2023) Registration is now open!

• MPGPCR Conference (November 15 -17, 2023)

• Structure, Mechanism, and Drug Interactions of GPCRs, Ion Channels, and Transport Proteins (March 24 - 29, 2024)

GPCR Jobs

• NEW Director, Discovery Toxicology

• NEW Postdoc Fellow - Dr. Robert Lefkowitz Lab

• NEW Postdoc Fellow - Dr. Robert Lefkowitz Lab

• Senior Research Specialist - Natural Sciences - Surgery

• Senior Scientist- Membrane Technologies

• Computational Protein Design (GPCR)

• Postdoctoral Fellow, Caron Lab

• Clinical Trial Associate

• Research Scientist/Senior Scientist I - Molecular Pharmacology

Explore Dr. GPCR Ecosystem