📰 GPCR Weekly News, July 24 to July 30, 2023

Welcome, GPCR fellows! Get excited about the latest GPCR news!

This week's highlights:

• Driving Pharma Innovation in Oncology: Domain Therapeutics' Success Proven by Science article.

• Dr. Terence Hébert’s work on Comparative study on human iPSC-derived vs. rat neonatal cardiomyocytes.

• Drs. Lukas Grätz, David Gloriam, and Gunnar Schulte’s research on Unveiling pathway selectivity in Frizzleds through conserved micro-switches.

Save the date! The upcoming Dr. GPCR Symposium on GPCRs as Therapeutic Modalities is on September 22nd. Want to share your work in an informal setting? Submit a 1-minute abstract video and tell us more about your project using this form. Then, join us on September 22nd for our discussion session, formerly known as The poster session, on Kumospace.

Stay tuned by subscribing to the Dr. GPCR Newsletter! We'll be sharing the list of our confirmed speakers soon!

In case you missed it, recordings of the Dr. GPCR Symposium on Structural and Molecular Insights on GPCR Activation are available for premium members to watch anytime.

And now let's check out the weekly Classified GPCR News from July 24th to July 30th, 2023.

Adhesion GPCRs

• Dual role of the adhesion G-protein coupled receptor ADRGE5/CD97 in glioblastoma invasion and proliferation.

GPCR Activation and Signaling

• Endosome positioning coordinates spatially selective GPCR signaling.

• Functions and mechanisms of the GPCR adaptor protein Norbin.

• G protein-coupled receptor-mediated membrane targeting of PLCγ2 is essential for neutrophil chemotaxis.

• Monoacylglycerol Lipase Protects the Presynaptic Cannabinoid 1 Receptor from Desensitization by Endocannabinoids after Persistent Inflammation.

• The role of leucine and isoleucine in tuning the hydropathy of class A GPCRs.

• Intracellular calcium ion transients evoked by cell poking independently of released autocrine ATP in Madin-Darby canine kidney cells.

• Pathway selectivity in Frizzleds is achieved by conserved micro-switches defining pathway-determining, active conformations.

GPCR Binders, Drugs, and more

• Development of a V5-tag-directed nanobody and its implementation as an intracellular biosensor of GPCR signalling.

GPCRs in Cardiology, Endocrinology, and Taste

• Insights on discovery, efficacy, safety and clinical applications of ghrelin receptor agonist capromorelin in veterinary medicine.

• Comparing the signaling and transcriptome profiling landscapes of human iPSC-derived and primary rat neonatal cardiomyocytes.

GPCRs in Neuroscience

• Neuronal diversity of neuropeptide signaling, including galanin, in the mouse locus coeruleus.

• The Neuromedin U system: pharmacological implications for the treatment of obesity and binge eating behavior.

• Profiling neuronal methylome and hydroxymethylome of opioid use disorder in the human orbitofrontal cortex.

GPCRs in Oncology and Immunology

• Interplay between G protein-coupled receptors and nanotechnology.

Methods & Updates in GPCR Research

• Strategies for acquisition of resonance assignment spectra of highly dynamic membrane proteins: a GPCR case study.

Structural and Molecular Insights into GPCR Function

• Ternary model structural complex of C5a, C5aR2, and β-arrestin1.

Industry News

• Omass Therapeutics Celebrates a Series of Recent Publications by their Scientists.

• Exscientia is the Sniper of the AI Drug Discovery Industry

• Indivior Announces Q2/H1 2023 Financial Results

• Scientists Discover a New Way To Develop Drugs Without Side Effects

• Driving Pharma Innovation in Oncology: Domain Therapeutics' Success Proven by Science

• Crinetics Hosting Key Opinion Leader Webinar To Discuss The Current Treatment Landscape And Unmet Need In Acromegaly

GPCR Events, Meetings, and Webinars

• ONCORNET2.0 Final Symposium (August 31 - September 1, 2023)

• NEW 3rd Transatlantic ECI GPCR Symposium (September 7 - 8, 2023)

• Discovery On Target (September 25 - 28, 2023) ○ NEW Training Seminar "The Renaissance in GPCRs as Drug Targets: Allosteric Function and Biased Signaling" (September 27 - 28, 2023)

• 3rd Annual Meeting IRN I-GPCRNet (October 25 - 27, 2023)

• GPCR Retreat (November 2 - 4, 2023)

• MPGPCR Conference (November 15 -17, 2023)

• NEW ASCEPT Annual Scientific Meeting (November 20 -23, 2023)

• Structure, Mechanism, and Drug Interactions of GPCRs, Ion Channels, and Transport Proteins (March 24 - 29, 2024)

GPCR Jobs

• Director, Discovery Toxicology

• Postdoc Fellow - Dr. Robert Lefkowitz Lab

• Postdoc Fellow - Dr. Robert Lefkowitz Lab

• Senior Research Specialist - Natural Sciences - Surgery

• Senior Scientist- Membrane Technologies

• Computational Protein Design (GPCR)

Explore Dr. GPCR Ecosystem