📰 GPCR Weekly News, July 3 to 9, 2023

Hello GPCR enthusiasts! We're here to share the latest GPCR news with you.

Congratulations to Dr. Graeme Milligan for receiving the Order of British Empire from King Charles III in recognition of his contributions to Biochemical Research and Industry.

Don't forget to mark your calendars for July 21st, as the upcoming Dr. GPCR Symposium on Structural and Molecular Insights on GPCR Activation is quickly approaching! This year's symposium will feature a trainee day with a career panel. If you're interested in presenting a poster, simply fill out the submission form and submit a 1-minute abstract video. Be sure to subscribe to Dr. GPCR Newsletter for updates!

Now, let's take a quick look at the Classified GPCR News from July 3rd to July 9th, 2023.

GPCR Activation and Signaling

• G protein activation via chemokine (C-X-C motif) receptor 4 and α1b -adrenoceptor is ligand and heteromer-dependent.

• The G protein-coupled receptor GPRC5C is a saccharide sensor with a novel "off" response.

• Mammalian type Opsin 5 preferentially activates G14 in Gq-type G proteins triggering intracellular calcium response.

• GPCR targeting of E3 ubiquitin ligase MDM2 by inactive β-arrestin.

GPCR Binders, Drugs, and more

• Rational design of highly stabilized and selective adrenomedullin analogs.

GPCRs in Cardiology, Endocrinology, and Taste

• SOCS3 inhibits the mesenchymal stromal cell secretory factor SDF-1-mediated improvement of islet function in non-obese diabetic mice.

GPCRs in Neuroscience

• A bistable inhibitory OptoGPCR for multiplexed optogenetic control of neural circuits.

GPCRs in Oncology and Immunology

• Minireview: functional roles of tissue kallikrein, kinins, and kallikrein-related peptidases in lung cancer.

Methods & Updates in GPCR Research

• Profiling of basal and ligand-dependent GPCR activities by means of a polyvalent cell-based high-throughput platform.

• Past, present, and future of tools for dopamine detection.

• Highly multiplexed bioactivity screening reveals human and microbiota metabolome-GPCRome interactions.

Structural and Molecular Insights into GPCR Function

• Dual mechanisms of cholesterol-GPCR interactions that depend on membrane phospholipid composition.

• Molecular Dynamics and Machine Learning Study of Adrenaline Dynamics in the Binding Pocket of GPCR.

Industry News

• Dr. Graeme Milligan was awarded the Order of British Empire by King Charles III for services to Biochemical Research and Industry.

• First Patient Enrolled in Phase 1/2 “ELUCIDATE” Trial Assessing GTAEXS617 in Advanced Solid Tumours

• A Conversation with Murat Tunaboylu, Antiverse Co-Founder and CEO

GPCR Events, Meetings, and Webinars

• ONCORNET2.0 Final Symposium (August 31 - September 1, 2023) Registration ends Tomorrow!

• 3rd Annual Meeting IRN I-GPCRNet (October 25 - 27, 2023)

• GPCR Retreat (November 2 - 4, 2023) Registration is now open!

• Structure, Mechanism, and Drug Interactions of GPCRs, Ion Channels, and Transport Proteins (March 24 - 29, 2024)

GPCR Jobs

• NEW Postdoctoral Fellow, Caron Lab

• NEW Clinical Trial Associate

• Research Scientist/Senior Scientist I - Molecular Pharmacology

• Vice President, Medical Affairs

• Associate Director / Director, Clinical Operations

• Professor in Cardiovascular Pharmacology

Explore Dr. GPCR Ecosystem