📰 GPCR Weekly News, June 12 to 18, 2023

Greetings GPCR enthusiasts! Join us to explore the fascinating world of GPCRs. This week's GPCR paper features an innovative publication by Dr. Silvio Gutkind.

But before we delve into the latest news, we'd like to highlight some upcoming events and resources:

• Save the date! July 21st marks our next Dr. GPCR Symposium on Structural and Molecular Insights on GPCR Activation. Check our website frequently for speaker updates. We're also actively seeking speakers and poster presenters for this and future symposiums. Showcase your research by contacting us at Hello@DrGPCR.com
  

• Stay informed with Dr. GPCR News by subscribing to our monthly newsletter.

Now, let's explore the weekly Classified GPCR News, at a glance from June 12th to June 18th, 2023.

GPCR Activation and Signaling

• Single transmembrane GPCR modulating proteins: neither single nor simple.

• Structural snapshots uncover a key phosphorylation motif in GPCRs driving β-arrestin activation.

• CLIC4 Regulates Endothelial Barrier Control by Mediating PAR1 Signaling via RhoA.

• A unique melanocortin-4-receptor signaling profile for obesity-associated constitutively active variants.

GPCRs in Neuroscience

• Orphan receptor GPR88 as a potential therapeutic target for CNS disorders - an in silico approach.

GPCRs in Oncology and Immunology

• The GPCR-Gαs-PKA signaling axis promotes T cell dysfunction and cancer immunotherapy failure.

• Stimulation of ectopically expressed muscarinic receptors induces IFN-γ but suppresses IL-2 production by inhibiting activation of pAKT pathways in primary T cells.

Methods & Updates in GPCR Research

• Spatiotemporal GPCR signaling illuminated by genetically encoded fluorescent biosensors.

Industry News

• Coherus to Acquire Surface Oncology

• Confo Therapeutics and AbCellera partner on GPCR-targeting antibodies

• GPCR Inhibition With ICB May Be Needed to Reactivate Antitumor Immune Response

• Garry Pairaudeau, CTO of Exscientia discuss transforming drug discovery using their AI-driven platform

• Salipro Biotech Expands Global Intellectual Property Portfolio with Granted Patent in Japan

• Proteros Biostructures GmbH Revolutionizes Metabolic Disorder Treatments

• Structure Therapeutics listed on Nasdaq

GPCR Events, Meetings, and Webinars

• NEW FREE ERNEST ECI zoominar (June 22, 2023)

• NEW Meet Inoviem Scientific Team (June 19 - 23, 2023)

• Training School on “Cell-based assays to study Adhesion GPCR function". (June 28 - 30, 2023)

• NEW FREE Seminar Antibodies targeting Membrane Proteins - From Antigen to New Therapeutics (June 30, 2023)

• FREE 11th Adrenoceptor Symposium: Adrenoceptors and GPCR Signalling (June 30 - July 1, 2023)

• 19th World Congress of Basic & Clinical Pharmacology 2023. (July 2 - 7, 2023).

• 3rd Annual Meeting IRN I-GPCRNet (October 25 - 27, 2023)

• GPCR Retreat (November 2 - 4, 2023)

• Structure, Mechanism, and Drug Interactions of GPCRs, Ion Channels, and Transport Proteins (March 24 - 29, 2024)

GPCR Jobs

• NEW Professor in Cardiovascular Pharmacology

• Scientist I / Scientist II DOE (Native Mass Spectrometry)

• Senior Vice President of Global Medical Affairs

• Postdoctoral Position on Gliovascular Unit of Glioblastoma

• Associate Director / Director, Clinical Operations

• Postdoctoral Research Associate

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