📰 GPCR Weekly News, June 3 to June 9, 2024

Hi everyone,

Please take a moment to explore our most recent coverage of GPCRs this week, which includes 15 insightful research papers and industry updates. Stay informed with the most recent developments in GPCR research and industry news.

This week's highlight includes congrats to:

• Dr. Monserrat Avila-Zozaya for her contributor article on Navigating the Signaling Network: RTK and GPCR Crosstalk Uncovered
  

• Drs. Jürgen Wess and Liu Liu for their study on A novel function of the M2 muscarinic receptor
  

• Drs. Zhan-Guo Gao, Mansour Haddad, and Kenneth A Jacobson for their work on A2B adenosine receptor signaling and regulation

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Dr. GPCR University

We are excited to announce that Dr. Terry Kenakin will return for two consecutive courses in September and October 2024. More details will be shared soon, and registration will open in July 2024.

Dr. GPCR Podcast

The 155th episode of the Dr. GPCR Podcast features a recap of the Endocrine Metabolic GPCRs 2024 with the organizers, Drs. Aylin Hanyaloglu, Caroline Gorvin, and Alejandra Tomas. It is now available for viewing in video format on our website. Catch up on missed episodes and immerse yourself in the visual experience!

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 GPCR Event Highlight

We are thrilled to share the news of our in-person event in partnership with the Adhesion GPCR Consortium: The 11th Adhesion GPCR Workshop. This significant event in adhesion GPCR Biology will be held in vibrant Mexico City from October 23 to 25, 2024. 

Join the global GPCR community to present your research—submit your abstract using this form. Deadline 1st round priority: June 24th / 2nd round: July 22th Do you have an artistic side? If so, participate in our logo contest for the event! Submit your logo and review the rules. The contest deadline is August 15th, 2024.

We are also offering sponsorship opportunities for this exciting event, which brings together scientists worldwide to explore all aspects of adhesion GPCR biology. Interested in sponsoring? Please email us at Hello@DrGPCR.com.

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Let’s dive into the Classified GPCR News from June 3rd to June 9th, 2024.

Adhesion GPCRs

• A correlation study of adhesion G protein-coupled receptors as potential therapeutic targets for breast cancer

GPCR Activation and Signaling

• The TAS1R2 G-protein-coupled receptor is an ambient glucose sensor in skeletal muscle that regulates NAD homeostasis and mitochondrial capacity

• Differential activation of rhodopsin triggers distinct endocytic trafficking and recycling in vivo via differential phosphorylation

• Increased transcriptional elongation and RNA stability of GPCR ligand binding genes unveiled via RNA polymerase II degradation

• Growth factor-dependent phosphorylation of Gαi shapes canonical signaling by G protein-coupled receptors

• Kinetic Model for the Desensitization of G Protein-Coupled Receptor

• RNA-seq screening and gene function analysis uncover GPR183 as a key mediator for methionine to stimulate milk synthesis in mouse mammary epithelial cells

GPCR Binders, Drugs, and more

• Structure-based identification of a G protein-biased allosteric modulator of cannabinoid receptor CB1

• GPCR function in autophagy control: a systematic approach of chemical intervention

Methods & Updates in GPCR Research

• ORP9-PH domain-based fluorescent reporters for visualizing phosphatidylinositol 4-phosphate dynamics in living cells

Reviews, GPCRs, and more

• Restoring function to inactivating G protein-coupled receptor variants in the hypothalamic-pituitary-gonadal axis1

• A novel function of the M2 muscarinic receptor

• A2B adenosine receptor signaling and regulation

• Novel medications for problematic alcohol use

Structural and Molecular Insights into GPCR Function

• Structural basis for recognition of 26RFa by the pyroglutamylated RFamide peptide receptor

Industry News

• NanoImaging Services and Cube Biotech Collaborate to Enhance Cryo-EM Enabled Gene to Structure Workflow

• Domain Therapeutics Strengthens Its Intellectual Property for Its Series of Treg Depleting anti-CCR8 Antibodies, Including Best-in-class Candidate DT-7012

• Crinetics Announces Positive Initial Findings at ENDO 2024 for Atumelnant in Two Ongoing, Open-Label Studies for the Treatment of Congenital Adrenal Hyperplasia (CAH) and ACTH-Dependent Cushing’s Syndrome (ADCS)

• Septerna Presents Preclinical Data at ENDO 2024 Highlighting Therapeutic Potential of its GPCR Drug Discovery Platform 

• GPCRs and Emotional Pain: Exploring Non-Narcotic Pathways to Relief 

GPCR Events, Meetings, and Webinars

• June 9 - 14, 2024 | 2024 Phosphorylation and G-Protein Mediated Signaling Networks

• June 25 - 29, 2024 | FENS Forum 2024

• October 2024 | Biologics US 2024 

• October 2 - 4, 2024 | 9th GPCRs in Medicinal Chemistry

• October 23 - 25, 2024 | 11th Adhesion GPCR Workshop

• July 12 - 17, 2026 | 20th World Congress of Basic and Clinical Pharmacology 2026

GPCR Jobs

• HIGHLIGHT Principal Scientist, In vitro pharmacology 

• Senior Scientist - Receptor Pharmacology

• Postdoctoral Scientist

• Senior Research Associate/Associate Scientist, Protein Science

• Post-Doctoral Fellow—Pharmacology/Cell Biology/Biochemistry

• Post Doctoral Fellow

• Postdoc Position

Join Dr. GPCR Ecosystem