📰 GPCR Weekly News, March 13 to 19, 2023

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Below is your Classified GPCR News at a glance for March 13th to 19th, 2023.

Adhesion GPCRs

• Crystal Structure of the Extracellular Domains of GPR110.

• Monitoring paxillin in astrocytes reveals the significance of the adhesion GPCR VLGR1/ADGRV1 for focal adhesion assembly.

GPCR Activation and Signaling

• Components of TOR and MAP kinase signaling control chemotropism and pathogenicity in the fungal pathogen Verticillium dahliae.

• A Rab10-ACAP1-Arf6 GTPases cascade modulates M4 muscarinic acetylcholine receptor trafficking and signaling.

• Neurotensin Receptor Allosterism Revealed in Complex with a Biased Allosteric Modulator.

• α1-adrenoceptor ligands inhibit chemokine receptor heteromerization partners of α1B/D-adrenoceptors via interference with heteromer formation.

• The immunometabolite itaconate stimulates OXGR1 to promote mucociliary clearance during the pulmonary innate immune response.

GPCR Binders, Drugs, and more

• Design of Drug Efficacy Guided by Free Energy Simulations of the β2-Adrenoceptor.

• Pharmacological characterization of novel small molecule agonists and antagonists for the orphan receptor GPR139.

• A small molecule ligand for the novel pain target, GPR171, produces minimal reward in mice.

• Monitoring the Reversibility of GPCR Signaling by Combining Photochromic Ligands with Label-free Impedance Analysis.

GPCRs in Cardiology, Endocrinology, and Taste

• Structure-based design of novel melanin-concentrating hormone receptor-1 ligands based on saturated nitrogen-containing heterocycles.

GPCRs in Neuroscience

• Physiological Condition-Dependent Changes in Ciliary GPCR Localization in the Brain.

• Endogenous l- to d-amino acid residue isomerization modulates selectivity between distinct neuropeptide receptor family members.

GPCRs in Oncology and Immunology

• Expanding role of CXCR2 and therapeutic potential of CXCR2 antagonists in inflammatory diseases and cancers.

Reviews, GPCRs, and more

• The leukotriene B4 receptors BLT1 and BLT2 as potential therapeutic targets.

• New paradigms in purinergic receptor ligand discovery.

• G protein-coupled receptor pharmacology - insights from mass spectrometry.

Structural and Molecular Insights into GPCR Function

• Structural basis of selective cannabinoid CB2 receptor activation.

• Structural basis for motilin and erythromycin recognition by motilin receptor.

Industry News

• Addex Announces Upcoming Conferences It Will Participate For H1 2023

• Learn more about Exscientia new pipeline candidate, EXS74539

• Domain Therapeutics unveiled its 2023 women-men professional equality index

• Octant introduces Hypatia, their New Robotic Drug Hunter

• GPCR Therapeutics Announces Publication in Nature Scientific Reports on Novel Anticancer Therapy

• An extraordinary opportunity to generate proprietary chemo-informatics for GPCR drug discovery - Design Pharmaceuticals

Call for GPCR Papers

• GPCRs: Signal Transduction. Deadline extended to March 31st, 2023.

GPCR Events, Meetings, and Webinars

• NEW 4th ERNEST GPCR ECI zoominar. (March 23, 2023)

• NEW 5th ERNEST GPCR ECI zoominar. (March 30, 2023)

• SLAS 2023 Building Biology in 3D Symposium. (April 20 - 21, 2023)

• NEW Swiss Biotech Day (April 24 - 25, 2023)

• SLAS Europe 2023 Conference and Exhibition. (May 22 - 26, 2023)

• 2nd LEAPS Meets Life Sciences Conference. (May 14 - 19, 2023)

• 8th and final ERNEST Meeting in Crete. (May 3 - 7, 2023).

• The Illuminating the Understudied Druggable Proteome Conference. (June 4 - 8, 2023).

• 2023 Molecular Pharmacology (GRS) Seminar GRC. (June 10 - 11, 2023).

• Progressive Technologies and Approaches Revealing Novel GPCR Biology and Drug Development Potential. (June 11 - 16, 2023).

• NEW Training School on “Cell-based assays to study Adhesion GPCR function". (June 28 - 30, 2023)

• 11th Adrenoceptor Symposium: Adrenoceptors and GPCR Signalling (June 30 - July 1, 2023)

• 19th World Congress of Basic & Clinical Pharmacology 2023. (July 2 - 7, 2023).

• 3rd Annual Meeting IRN I-GPCRNet (October 25 - 27, 2023)

GPCR Jobs

• Postdoctoral positions at UC San Diego

• Medical Director

• CADD and Informatics Head or Team Lead (depending on experience) with Structural Bioinformatics Expertise

• Scientist

• Corporate Strategy Analyst

• PhD candidate or Postdoc.

• Director, Head of PMO.

• Associate Scientist, Protein Science.

Explore Dr. GPCR Ecosystem