📰 GPCR Weekly News, March 18 to 24, 2024

Hello readers! BIG NEWS! Check out our GPCR coverage for this week. We have 15 GPCR papers and four industry news.

This week's highlight includes congrats to:

• Drs. Miles Thompson, Alexander Hauser, Caroline Gorvin et al. for their research on GPCR gene variants and human genetic disease.

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Dr. GPCR Symposia

With a premium membership, you can watch on-demand the Dr. GPCR Symposium on GPCR activation and signaling sessions. Our next symposium on Structural and Molecular Insights into GPCR Function. is scheduled for June 7th. Stay tuned for more updates.

If you want to showcase your research, you can submit a poster presentation to our community, take advantage of networking opportunities, and raise your profile on our platform. Get started by filling out this form!

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Dr. GPCR Partnered Events

• April 22 - 23, 2024 | Endocrine Metabolic GPCRs Join the Endocrine Metabolic GPCRs event in Birmingham, UK, on April 22-23, 2024. 

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 Let’s dive into the Classified GPCR News from March 18th to 24th, 2024

GPCR Activation and Signaling

• Calcium-Driven In Silico Inactivation of a Human Olfactory Receptor

• Deciphering the role of glycosaminoglycans in GPCR signaling

• G protein-coupled receptor-mediated autophagy in health and disease

GPCR Binders, Drugs, and more

• Elucidation of active components and target mechanism in Jinqiancao granules for the treatment of prostatitis and benign prostatic hyperplasia

GPCRs in Cardiology, Endocrinology, and Taste

• Blockade of endothelial adenosine receptor 2A suppresses atherosclerosis in vivo through inhibiting CREB-ALK5-mediated endothelial to mesenchymal transition

• Role of pH-sensing receptors in colitis

GPCRs in Oncology and Immunology

• Polarizing itch

• Biochemical pharmacology of adenylyl cyclases in cancer

Methods & Updates in GPCR Research

• A multicolor suite for deciphering population coding of calcium and cAMP in vivo

• Cryo-EM advances in GPCR structure determination

• Visualization of endogenous G proteins on endosomes and other organelles

Reviews, GPCRs, and more

• G protein-coupled receptor (GPCR) gene variants and human genetic disease

• Advances and challenges in cancer immunoprevention and immune interception

Structural and Molecular Insights into GPCR Function

• Structural bioinformatics studies of serotonin, dopamine and norepinephrine transporters and their AlphaFold2 predicted water-soluble QTY variants and uncovering the natural mutations of L->Q, I->T, F->Y and Q->L, T->I and Y->F

Industry News

• Sosei Heptares Doses First Subject in Phase 1 Trial with HTL0033744, an EP4 Agonist for Inflammatory Bowel Disease (IBD)

• Domain Therapeutics and Chime Biologics Form Manufacturing Pact for Antibody Cancer Immunotherapy

• Sosei Heptares Regains Full Ownership from GSK of HTL0027477, a Clinic-ready, First-in-Class Oral GPR35 Agonist for Inflammatory Bowel Disease

• Crinetics’ Once-Daily Oral Paltusotine Achieved The Primary And All Secondary Endpoints In The Phase 3 Pathfndr-2 Study In Acromegaly Patients

GPCR Events, Meetings, and Webinars

• March 24 - 29, 2024 | Ligand Recognition and Molecular Gating Conference

• April 1 - 4, 2024 | 19th Annual Drug Discovery Chemistry

• April 4 - 7, 2024 | American Physiology Summit

• April 5 - 10, 2024 | AACR Annual Meeting

• May 13 - 17, 2024 | 20th Annual PEGS Boston Summit

• May 16 - 19, 2024 | ASPET 2024

• May 27 - 29, 2024 | SLAS Europe 2024 Conference and Exhibition

• June 2 - 7, 2024 | Chemotactic Cytokines

• June 9 - 14, 2024 | 2024 Phosphorylation and G-Protein Mediated Signaling Networks

• June 25 - 29, 2024 | FENS Forum 2024

• October 2024 | Biologics US 2024 

• October 2 - 4, 2024 | 9th GPCRs in Medicinal Chemistry

• October 23 - 25, 2024 | 11th Adhesion GPCR Workshop

• July 12 - 17, 2026 | 20th World Congress of Basic and Clinical Pharmacology 2026

GPCR Jobs

• Postdoctoral Associate

• Research Technologist I 

• Senior Scientist- Internal Medicine Research Unit

• Postdoctoral Scholar – Synaptic physiology, optical imaging, substance use disorder, pharmacology

• Research Fellow

• Postdoctoral Fellow – Molecular Pharmacology of Feeding Behavior 

• Director of Laboratory Operations - Single-molecule Imaging Center

• Scientific Assistant 

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