📰 GPCR Weekly News, March 4 to 10, 2024

Hi readers! Get the latest updates on breakthroughs in GPCR research with our concise and comprehensive summaries. Stay ahead of the curve!

This week's highlight includes congrats to

• Drs. Khaled Abd-Elrahman, Stephen Ferguson et al. Their research reveals how VU0486846 reduces neurogliosis in female Alzheimer's mice.

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Dr. GPCR Symposia

TOMORROW, we are hosting a symposium on GPCR activation and signaling. We are pleased to confirm the participation of a great lineup of speakers, namely Drs. Franziska Heydenreich, Sudarshan Rajagopal, Graham Ladds, Cesare Orlandi, Simone Prömel and Michel Bouvier. Additionally, we are having a Panel Discussion on Publishing in Academia with Drs. Stuart Maudsley, Nicole Perry-Hauser, Lauren Slosky, Cesare Orlandi, and Simone Prömel.

Please note that we moved our clocks ahead in North America. If you are joining from anywhere else in the world, please plan accordingly.

Don't miss out, and mark your calendar! 

Dr. GPCR University

Save the date for our upcoming workshop starting May 9th, 2024, featuring Dr. Sam Hoare as our instructor. Gain invaluable skills in data analysis under Dr. Hoare's expert guidance. More details are coming soon—stay tuned!

Dr. Terry Kenakin's "Applying Pharmacology to Drug Discovery" course at Dr. GPCR University was tremendously successful. If you're eager to attend, join our waitlist for updates on its return later this year. Those on the waitlist will be the first notified of the course dates, so hurry.

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Dr. GPCR Partnered Events

• April 22 - 23, 2024 | Endocrine Metabolic GPCRs Join the Endocrine Metabolic GPCRs event in Birmingham, UK, on April 22-23, 2024. 

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 Let’s dive into the Classified GPCR News from March 4th to 10th, 2024

GPCR Activation and Signaling

• Glu1022.53-Mediated Early Conformational Changes in the Process of Light-Induced Green Cone Pigment Activation

• Molecular dynamics-based identification of binding pathways and two distinct high-affinity sites for succinate in succinate receptor 1/GPR91

• Specific pharmacological and Gi/o protein responses of some native GPCRs in neurons

• Beyond the Nucleus: Plastic Chemicals Activate G Protein-Coupled Receptors

GPCRs in Neuroscience

• A M1 muscarinic acetylcholine receptor-specific positive allosteric modulator VU0486846 reduces neurogliosis in female Alzheimer's mice

• The association of GNB5 with Alzheimer disease revealed by genomic analysis restricted to variants impacting gene function

• Interaction modes of human orexin 2 receptor with selective and nonselective antagonists studied by NMR spectroscopy

• Up-regulation of GPR139 in the medial septum ameliorates cognitive impairment in two mouse models of Alzheimer's disease

GPCRs in Oncology and Immunology

• Itaconate in host inflammation and defense

Methods & Updates in GPCR Research

• Improved green and red GRAB sensors for monitoring spatiotemporal serotonin release in vivo

Reviews, GPCRs, and more

• 2023 Julius Axelrod Symposium: Plant-derived molecules acting on GPCRs

• Molecular characterization of recombinant LSDV isolates from 2022 outbreak in Indonesia through phylogenetic networks and whole-genome SNP-based analysis

Industry News

• Boehringer Ingelheim and Sosei Heptares join forces to develop first-in-class treatments targeting all symptoms of schizophrenia

• Sosei Heptares to receive US$2.5 million milestone payment from Formosa Pharmaceuticals

• Are GLP-1s finding the right balance in obesity?

• Deciphering the role of GPCRs in obesity pathology for drug development  

GPCR Events, Meetings, and Webinars

• March 13 - 15 | Biologics 2024 

• March 13 - 15 | 9th German Pharm-Tox Summit 

• March 23 - 24, 2024 | Ligand Recognition and Molecular Gating Seminar

• March 24 - 29, 2024 | Ligand Recognition and Molecular Gating Conference

• April 1 - 4, 2024 | 19th Annual Drug Discovery Chemistry

• April 4 - 7, 2024 | American Physiology Summit

• April 5 - 10, 2024 | AACR Annual Meeting

• May 13 - 17, 2024 | 20th Annual PEGS Boston Summit

• May 16 - 19, 2024 | ASPET 2024

• May 27 - 29, 2024 | SLAS Europe 2024 Conference and Exhibition

• June 2 - 7, 2024 | Chemotactic Cytokines

• June 9 - 14, 2024 | 2024 Phosphorylation and G-Protein Mediated Signaling Networks

• June 25 - 29, 2024 | FENS Forum 2024

• October 2024 | Biologics US 2024 

• October 2 - 4, 2024 | 9th GPCRs in Medicinal Chemistry

• October 23 - 25, 2024 | 11th Adhesion GPCR Workshop

• July 12 - 17, 2026 | 20th World Congress of Basic and Clinical Pharmacology 2026

GPCR Jobs

• NEW Research Technologist I 

• Senior Scientist- Internal Medicine Research Unit

• Postdoctoral Scholar – Synaptic physiology, optical imaging, substance use disorder, pharmacology

• Research Fellow

• Postdoctoral Fellow – Molecular Pharmacology of Feeding Behavior 

• Director of Laboratory Operations - Single-molecule Imaging Center

• Scientific Assistant 

• Postdoctoral Fellowship- Mechanistic Biology 

Join Dr. GPCR Ecosystem