📰 GPCR Weekly News, March 6 to 12, 2023

Hello Readers👋,

Thank you for being here with us this week. We work tirelessly to bring you informative and exciting news about the world of GPCR every Thursday.

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Are you ready for our first Dr. GPCR Symposium event held on March 24th? If you'd like to present a poster, please submit yours today.

There is no limit to the number of posters we can accommodate, so hurry and submit your poster so that we can add it to the list of posters and increase the number of people who can ''stop by'' it on March 24th, 2023.

Below is your Classified GPCR News at a glance for March 6th to 12th, 2023.

GPCR Activation and Signaling

• Autoregulation of GPCR signalling through the third intracellular loop.

GPCR Binders, Drugs, and more

• Autoantibodies targeting G protein-coupled receptors: An evolving history in autoimmunity. Report of the 4th international symposium.

• Discovery, synthesis and mechanism study of 2,3,5-substituted [1,2,4]-thiadiazoles as covalent inhibitors targeting 3C-Like protease of SARS-CoV-2.

• Novel Xanomeline-Containing Bitopic Ligands of Muscarinic Acetylcholine Receptors: Design, Synthesis and FRET Investigation.

GPCRs in Neuroscience

• Quinpirole ameliorates nigral dopaminergic neuron damage in Parkinson's disease mouse model through activating GHS-R1a/D2R heterodimers.

• The crosstalk between 5-HT2AR and mGluR2 in schizophrenia.

GPCRs in Oncology and Immunology

• GPR176 Promotes Cancer Progression by Interacting with G Protein GNAS to Restrain Cell Mitophagy in Colorectal Cancer.

• Intermediate-state-trapped mutants pinpoint G protein-coupled receptor conformational allostery.

Structural and Molecular Insights into GPCR Function

• Endogenous l- to d-amino acid residue isomerization modulates selectivity between distinct neuropeptide receptor family members.

• Molecular sensing of mechano- and ligand-dependent adhesion GPCR dissociation.

• Structural basis of peptide recognition and activation of endothelin receptors.

Industry News

• Professor Dame Carol Robinson Received 2023 ASMS John.B.Fenn Award

• Exscientia Announces Expansion of its Precision Oncology Pipeline

• Exscientia to Present Data Highlighting Pipeline and Precision Medicine Platform at AACR

• Fast Company has named Exscientia as one of the Most Innovative Companies of 2023

• Dirk Loeffert CEO & Founder DesignPharma Interview

• GPCR-targeting drugs: A renewed focus on a ubiquitous group of proteins

• arcoscreen will be at Bio-Europe 2023 in Basel.

• Domain Therapeutics was nominated for the Trophée de l'Innovation Technologique (Technological Innovation Award)

• Sosei Heptares Receives Approval for Change of Market Listing Segment to the Tokyo Stock Exchange

Call for GPCR Papers

• GPCRs: Signal Transduction. Deadline extended to March 31st, 2023.

GPCR Events, Meetings, and Webinars

• GEM2023. (March 14-17, 2023).

• SLAS 2023 Building Biology in 3D Symposium. (April 20 - 21, 2023)

• SLAS Europe 2023 Conference and Exhibition. (May 22 - 26, 2023)

• 2nd LEAPS Meets Life Sciences Conference. (May 14 - 19, 2023)

• 8th and final ERNEST Meeting in Crete. (May 3 - 7, 2023).

• The Illuminating the Understudied Druggable Proteome Conference. (June 4 - 8, 2023).

• 2023 Molecular Pharmacology (GRS) Seminar GRC. (June 10 - 11, 2023).

• Progressive Technologies and Approaches Revealing Novel GPCR Biology and Drug Development Potential. (June 11 - 16, 2023).

• 11th Adrenoceptor Symposium: Adrenoceptors and GPCR Signalling (June 30 - July 1, 2023)

• 19th World Congress of Basic & Clinical Pharmacology 2023. (July 2 - 7, 2023).

• 3rd Annual Meeting IRN I-GPCRNet (October 25 - 27, 2023)

GPCR Jobs

• CADD and Informatics Head or Team Lead (depending on experience) with Structural Bioinformatics Expertise

• Scientist

• Corporate Strategy Analyst

• PhD candidate or Postdoc.

• Director, Head of PMO.

• Associate Scientist, Protein Science.

• PhD Studentship - Integrated Approaches In Pharmacology, Computer Simulations And Machine Learning To Predict Ligand Signaling Pathways Via The Anti-Inflammatory Receptor Gpr84.

• PhD Studentship - Insight Into The Neuroprotective Function Of The Prostaglandin Receptor Ep2.

Explore Dr. GPCR Ecosystem