📰 GPCR Weekly News, May 15 to 21, 2023

Hi GPCR buffs 👋! This week's GPCR papers feature a publication from Dr. Marta Filizola. Check it out!

The Dr. GPCR Symposium on GPCR Activation and Signaling was a great success. We express our gratitude to the speakers for their excellent talks.

Our next symposium is on July 21st, 2023, focusing on Structural and Molecular Insights into GPCR Activation. If you are interested in giving a talk, contact us at Hello@DrGPCR.com, and if you would like to present a poster, submit this form here. Take the chance to contribute to this exciting event!

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Below is your Classified GPCR News at a glance for May 15th to 21st, 2023.

GPCR Activation and Signaling

• Monitoring the Reversibility of GPCR Signaling by Combining Photochromic Ligands with Label-free Impedance Analysis.

• FSLLRY-NH2, a protease-activated receptor 2 (PAR2) antagonist, activates mas-related G protein-coupled receptor C11 (MrgprC11) to induce scratching behaviors in mice.

• ACE2 Activation by Tripeptide IRW (Ile-Arg-Trp) Depends on the G Protein-Coupled Receptor 30 Signaling Cascade.

• Gαs slow conformational transition upon GTP binding and a novel Gαs regulator.

GPCRs in Neuroscience

• Conformationally Selective 2-Aminotetralin Ligands Targeting the alpha2A- and alpha2C-Adrenergic Receptors.

• A vital role for PICK1 in the differential regulation of metabotropic glutamate receptor internalization and synaptic AMPA receptor endocytosis.

GPCRs in Oncology and Immunology

• Stable Binding of Full-Length Chemerin is Driven by Negative Charges in the CMKLR1 N-terminus.

Methods & Updates in GPCR Research

• Computational design of dynamic receptor-peptide signaling complexes applied to chemotaxis.

Reviews, GPCRs, and more

• Analysis of the Dynamics of the Human Growth Hormone Secretagogue Receptor Reveals Insights into the Energy Landscape of the Molecule.

Industry News

• X4 Pharmaceuticals Announces $65 Million Private Placement Priced At-the-Market

• Andrew Hopkins, Exscientia’s founder and CEO was elected a Fellow of the Academy of Medical Sciences

• Structure Therapeutics Announces Poster Presentations at the American Thoracic Society International Conference

GPCR Events, Meetings, and Webinars

• SLAS Europe 2023 Conference and Exhibition. (May 22 - 26, 2023)

• 2nd LEAPS Meets Life Sciences Conference. (May 14 - 19, 2023)

• PEGS Boston (May 15 - 19, 2023)

• 8th and final ERNEST Meeting in Crete. (May 3 - 7, 2023).

• The Illuminating the Understudied Druggable Proteome Conference. (June 4 - 8, 2023).

• 2023 Molecular Pharmacology (GRS) Seminar GRC. (June 10 - 11, 2023).

• Progressive Technologies and Approaches Revealing Novel GPCR Biology and Drug Development Potential. (June 11 - 16, 2023).

• FREE Symposium - IPI Surfacing (June 15, 2023)

• Training School on “Cell-based assays to study Adhesion GPCR function". (June 28 - 30, 2023)

• FREE 11th Adrenoceptor Symposium: Adrenoceptors and GPCR Signalling (June 30 - July 1, 2023)

• 19th World Congress of Basic & Clinical Pharmacology 2023. (July 2 - 7, 2023).

• 3rd Annual Meeting IRN I-GPCRNet (October 25 - 27, 2023)

GPCR Jobs

• NEW Postdoctoral Research Associate

• NEW Lab Manager

• Vice President, Medical Affairs

• Associate Scientist - Technology

• Senior Research Scientist/Principal Scientist- Technology

• Tissue Culture Scientist/Tissue Culture Manager

• Postdoctoral Researcher

• Director - Targeted Oncology

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