📰 GPCR Weekly News, May 20 to 26, 2024

Hello everyone!

Check out our latest coverage of GPCRs this week, featuring 15 insightful research papers and industry updates. Stay informed with the latest GPCR research and industry news.

This week's highlight includes congrats to:

• Cam Sinh Lu, for his first Dr. GPCR contributor article Extracellular signal-regulated kinases – a potential pathway for GPCR-targeted drug discovery
  

• Nicola J Smith, Lauren T May, and Natasha L Grimsey for their work on Highlights and hot topics in GPCR research from 'Down Under'

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Dr. GPCR University

Today marks the final day of the Dr. GPCR University workshop on Advanced Data Analysis for GPCR Pharmacology, led by the esteemed Dr. Sam Hoare. It's been a remarkable experience with participants joining us from around the globe.

We're thrilled to announce that Dr. Terry Kenakin will return for two consecutive courses in September and October 2024. Stay tuned for more details, and be ready to register in July 2024.

Dr. GPCR Podcast

We have thrilling news—Episode 153 of the Dr. GPCR Podcast featuring Dr. Jacek Mokrosiński is live! Titled "Embracing Networking for Professional Growth"

Our podcast episodes are now available in video format on our website. Revisit your favorite episodes and catch up on any you’ve missed. Tune in and enjoy the visual experience!

Dr. GPCR Matchmaking

Read Mark's job spotlight article for a Principal Scientist in In Vitro Pharmacology! Mark recently discussed this exciting opportunity with Beth Fleck, Director of In Vitro Pharmacology at Crinetics Pharmaceuticals!

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GPCR Event Highlight

We are delighted to announce our first in-person event in collaboration with the Adhesion GPCR Consortium: The 11th Adhesion GPCR Workshop will be held in vibrant Mexico City from October 23 to 25, 2024.

Join the global GPCR community and share your research—submit your abstract using this form.

We are also seeking sponsors to support this exciting event that unites scientists worldwide to explore all aspects of adhesion GPCR biology. Interested in sponsoring? Please email us at Hello@DrGPCR.com.

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Let’s dive into the Classified GPCR News from May 20th to 26th, 2024.

Adhesion GPCRs

• Adhesion G Protein-Coupled Receptor Gpr126 (Adgrg6) Expression Profiling in Diseased Mouse, Rat, and Human Kidneys

GPCR Activation and Signaling

• Differential regulation of G protein-coupled receptor-associated proteins in the caudate and the putamen of cynomolgus macaques following chronic ethanol drinking

• GRK5 is required for adipocyte differentiation through ERK activation

GPCR Binders, Drugs, and more

• Flipping the GPCR Switch: Structure-Based Development of Selective Cannabinoid Receptor 2 Inverse Agonists

• Development of Putative Bivalent Dicovalent Ligands for the Adenosine A1 Receptor

GPCRs in Cardiology, Endocrinology, and Taste

• Sodium/Potassium ATPase Alpha 1 Subunit Fine-tunes Platelet GPCR Signaling Function and is Essential for Thrombosis

GPCRs in Oncology and Immunology

• Enterococcus-derived tyramine hijacks α2A-adrenergic receptor in intestinal stem cells to exacerbate colitis

• The EBI2 receptor is coexpressed with CCR5 in CD4+ T cells and boosts HIV-1 R5 replication

Methods & Updates in GPCR Research

• Evaluation and comparison of colorimetric outputs for yeast-based biosensors in laboratory and point-of-use settings

• Quantitative proteomics reveals CLR interactome in primary human cells

• Exploiting Cell-Based Assays to Accelerate Drug Development for G Protein-Coupled Receptors

• TOR signaling regulates GPCR levels on the plasma membrane and suppresses the Saccharomyces cerevisiae mating pathway

Reviews, GPCRs, and more

• Highlights and hot topics in GPCR research from 'Down Under'

• Apelin receptor dimer: Classification, future prospects, and pathophysiological perspectives

Structural and Molecular Insights into GPCR Function

• Bilayer lipids modulate ligand binding to atypical chemokine receptor 3

Industry News

• New cannabinoid CB1 receptor antagonists disclosed in Inversago patent

• Orion Biotechnology will be attending BIO 2024

• Antiverse is attending BIO 2024

• Septerna to Present Preclinical Data from GPCR Drug Discovery Engine at ENDO 2024

• The Promise of Oxytocin: Novel Approaches for Targeting Oxytocin Receptors in Autism Spectrum Disorder and Psychiatric Disorders

GPCR Events, Meetings, and Webinars

• NEW June 1 - 4, 2024 | ENDO 2024

• NEW June 3 - 6, 2024 | BIO 2024

• June 2 - 7, 2024 | Chemotactic Cytokines

• June 4, 2024 | Live Webinar ‘It All Starts With a Protein – Protein Sciences as a Key to Success in Drug Discovery’ 

• June 9 - 14, 2024 | 2024 Phosphorylation and G-Protein Mediated Signaling Networks

• June 25 - 29, 2024 | FENS Forum 2024

• October 2024 | Biologics US 2024 

• October 2 - 4, 2024 | 9th GPCRs in Medicinal Chemistry

• October 23 - 25, 2024 | 11th Adhesion GPCR Workshop

• July 12 - 17, 2026 | 20th World Congress of Basic and Clinical Pharmacology 2026

GPCR Jobs

• HIGHLIGHT Principal Scientist, In vitro pharmacology 

• NEW Senior Scientist - Receptor Pharmacology

• NEW PostDoctoral Scientist

• Senior Research Associate/Associate Scientist, Protein Science

• Post-Doctoral Fellow—Pharmacology/Cell Biology/Biochemistry

• Post Doctoral Fellow

• Postdoc Position

• Senior Associate Scientist - Global Research Technologies Novo Nordisk

• Scientist I - Global Research Technologies Novo Nordisk

Join Dr. GPCR Ecosystem