📰 GPCR Weekly News, May 6 to 12, 2024

Hello everyone!

Don't miss out on our latest coverage of GPCRs for this week. We have a total of 34 insightful GPCR research papers and seven updates from the industry. Stay informed and up to date with the latest GPCR research and industry news.

This week's highlight includes congrats to:

• Drs. Sara Marsango and Graeme Milligan for their research on the Regulation of the pro-inflammatory G protein-coupled receptor GPR84

• Drs. Chakit Arora, J Silvio Gutkind, and Francesco Raimondi for their work on The landscape of cancer-rewired GPCR signaling axes

• Affiong Ika Oqua, Dr. Alejandra Tomas, et al. for their study on Lipid regulation of the glucagon receptor family

• Drs. Naveen Thakur, Kenneth A Jacobson, Matthew T Eddy, et al. for their analysis on Membrane mimetic-dependence of GPCR energy landscapes

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Dr. GPCR University

We successfully started our Dr.GPCR University workshop, 'Advanced Data Analysis for GPCR Pharmacology,’ led by Dr. Sam Hoare.

Mark your calendar for September and October 2024. Dr. Kenakin will be back with two back-to-back classes. Stay tuned as we plan to open registrations for both classes in July 2024.

Dr. GPCR Podcast

Episode #151 is out! A special episode with our board, meet Drs. Maria Waldhoer, JoAnn Trejo, and Anne Marie Quinn.

Did you watch Episode #150 of the Dr. GPCR Podcast? Join us in this episode to meet the team behind Dr. GPCR, hear anecdotes, and get important announcements. Tune in and be the first to know about the benefits coming your way!

Dr. GPCR Matchmaking

Mark Schmeizl, our Chief Matchmaker, can help you find your perfect match if you want to hire or be hired. Mark has experience connecting candidates with employers and will work with you to understand your needs and preferences to ensure a successful match. Contact Mark today to get started.

Dr. GPCR Symposia

Learn more about GPCRs by signing up for a Premium Membership to watch all the material recorded at our previous events, including the three editions of the Dr. GPCR Summit.

We have postponed our symposium on Structural Insights into GPCR Activation to a later date. Stay tuned for our next symposium on GPCRs as Therapeutics Targets on October 11th, 2024.

In the meantime, visit Dr. GPCR Symposia and learn from experts in the field.

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GPCR Event Highlight

We are thrilled to partner with the Adhesion GPCR Consortium to organize our first Dr. GPCR in-person event. Mark your calendar for October 23 - 25, 2024, as we kick off the 11th Adhesion GPCR Workshop in Mexico City.

Abstract submissions and registrations will open soon. Stay tuned

We are also looking for sponsors to help support this fabulous event that brings together scientists worldwide working on all aspects of adhesion GPCR biology. Please reply to this email if you'd like to sponsor this event.

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 Let’s dive into the Classified GPCR News from April 29th to May 12th, 2024

Adhesion GPCRs

• Essential Role of Latrophilin-1 Adhesion GPCR Nanoclusters in Inhibitory Synapses

• Embryonic spatiotemporal expression pattern of Folded gastrulation suggests roles in multiple morphogenetic events and regulation by AbdA

GPCR Activation and Signaling

• The critical importance of conditions: Reconciling GPCR functionality and biophysical findings

• Adrenoceptor Desensitization: Current Understanding of Mechanisms

• Biased agonists of GPR84 and insights into biological control

• GPR84 in physiology-Many functions in many tissues

• Regulation of the pro-inflammatory G protein-coupled receptor GPR84

• Function and regulation of GPR84 in human neutrophils

• Large-scale deorphanization of Nematostella vectensis neuropeptide G protein-coupled receptors supports the independent expansion of bilaterian and cnidarian peptidergic systems

GPCR Binders, Drugs, and more

• A relaxin receptor gene RpGPCR41 is involved in the resistance of Rhopalosiphum padi to pyrethroids

• Discovering allatostatin type-C receptor specific agonists

• Discovery of the Clinical Candidate IDOR-1117-2520: A Potent and Selective Antagonist of CCR6 for Autoimmune Diseases

• MRGPRX4 mediates phospho-drug-associated pruritus in a humanized mouse model

GPCRs in Cardiology, Endocrinology, and Taste

• The Genetic Pathophysiology and Clinical Management of the TADopathy, X-Linked Acrogigantism

• Thrombosis With Thrombocytopenia and Post-COVID-Vaccination Syndrome With Anti-G-Protein-Coupled Receptor (GPCR) Antibodies Treated With Therapeutic Plasma Exchange

• SUCNR1 regulates insulin secretion and glucose elevates the succinate response in people with prediabetes

GPCRs in Neuroscience

• Spatiotemporal organization of prefrontal norepinephrine influences neuronal activity

• Transient cAMP production drives rapid and sustained spiking in brainstem parabrachial neurons to suppress feeding

• The C-terminus of the prototypical M2 muscarinic receptor localizes to the mitochondria and regulates cell respiration under stress conditions

GPCRs in Oncology and Immunology

• Wnt pathway inhibition with the porcupine inhibitor LGK974 decreases trabecular bone but not fibrosis in a murine model with fibrotic bone

• The orphan G protein-coupled receptor 141 expressed in myeloid cells functions as an inflammation suppressor

• The landscape of cancer-rewired GPCR signaling axes

Methods & Updates in GPCR Research

• ONE-GO: Direct detection of context-dependent GPCR activity

• Author Correction: GPCR molecular dynamics forecasting using recurrent neural networks

• Glycoprotein-glycoprotein receptor binding detection using bioluminescence resonance energy transfer

• Bayesian network models identify cooperative GPCR:G protein interactions that contribute to G protein coupling

Reviews, GPCRs, and more

• Molecular adaptations in response to exercise training are associated with tissue-specific transcriptomic and epigenomic signatures

• Lipid regulation of the glucagon receptor family

• Technologies for the discovery of G protein-coupled receptor-targeting biologics

• Lipid mediators in neutrophil biology: inflammation, resolution and beyond

• Exploring GPCR signaling pathway networks as cancer therapeutic targets

• Generation of comprehensive GPCR-transducer-deficient cell lines to dissect complexity of GPCR signaling

Structural and Molecular Insights into GPCR Function

• Membrane mimetic-dependence of GPCR energy landscapes

• Structural and Computational Insights into Dynamics and Intermediate States of Orexin 2 Receptor Signaling

Industry News

• Addex Gets Creative To Secure Funding And Its Future

• Reunion Neuroscience Inc. Announces $103 Million Series A Financing Co-Led by MPM BioImpact and Novo Holdings

• Neurocrine Biosciences Announces Initiation of Phase 1 Clinical Study Evaluating Effects of NBI-1117567 in Healthy Adults

• Crinetics Pharmaceuticals Reports First Quarter 2024 Financial Results and Provides Business Update

• Nxera Pharma Operational Highlights and Consolidated Results for the First Quarter 2024

• Crinetics Pharmaceuticals To Present Advancements From Atumelnant (Crn04894) And Paltusotine Development Programs At Endo 2024

• Exscientia's CEO shares a pipeline overview and learnings from being one of the first AI companies out front and to go public
  

GPCR Events, Meetings, and Webinars

• May 13 - 17, 2024 | 20th Annual PEGS Boston Summit

• May 16 - 19, 2024 | ASPET 2024

• May 27 - 29, 2024 | SLAS Europe 2024 Conference and Exhibition

• June 2 - 7, 2024 | Chemotactic Cytokines

• June 9 - 14, 2024 | 2024 Phosphorylation and G-Protein Mediated Signaling Networks

• June 25 - 29, 2024 | FENS Forum 2024

• July 8 - 10, 2024 | 4th IRN i-GPCRnet Annual

• October 2024 | Biologics US 2024 

• October 2 - 4, 2024 | 9th GPCRs in Medicinal Chemistry
  

• July 12 - 17, 2026 | 20th World Congress of Basic and Clinical Pharmacology 2026

GPCR Jobs

• Post Doctoral Fellow

• Postdoc Position

• Principal Scientist, In vitro Pharmacology

• Senior Associate Scientist - Global Research Technologies Novo Nordisk

• Scientist I - Global Research Technologies Novo Nordisk

• Postdoctoral Associate

• Research Technologist I 

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