📰 GPCR Weekly News, November 13 to 19, 2023

Hi there readers! This week we’ve curated 13 GPCR papers, 1 new event, 11 industry news, and 3 job offers! Check out our GPCR roundup now, and be the first to read!

This week's highlight:

• Drs. Brian Krumm and Bryan Roth studied CryoEM structures of adhesion in GPCR CD97, filling gaps.

Last Friday was our final Dr. GPCR Symposium for the year, focusing on GPCRs in Immunology and Oncology, concluding the Dr. GPCR Symposia 2023. We extend immense gratitude to our exceptional speakers and all attendees who participated. For those who joined any of our symposium sessions, we kindly request a moment of your time to fill out our survey.

If you weren't able to attend, don't worry – our premium members have continuous access to revisit and watch the archived presentations at any time HERE.

Sign up for Dr. GPCR Newsletter and stay ahead of the curve with news on the Dr. GPCR University live courses we are preparing for you in 2024.

Now let’s dive into the weekly Classified GPCR News from November 13th to 19th, 2023.

Adhesion GPCRs

• CryoEM structures of adhesion in GPCR CD97: Filling in some of the gaps

GPCR Activation and Signaling

• Butyrate induces STAT3/HIF-1α/IL-22 signaling via GPCR and HDAC3 inhibition to activate autophagy in head kidney macrophages from turbot (Scophthalmus maximus L.)

• Endosomal signaling via cAMP in parathyroid hormone (PTH) type 1 receptor biology

• β-arrestin1 is an E3 ubiquitin ligase adaptor for substrate linear polyubiquitination

GPCR Binders, Drugs, and more

• Dual allosteric and orthosteric pharmacology of synthetic analog cannabidiol-dimethylheptyl, but not cannabidiol, on the cannabinoid CB2 receptor

GPCRs in Cardiology, Endocrinology, and Taste

• Transcriptomic changes in glomeruli in response to a high salt challenge in the Dahl SS rat

GPCRs in Neuroscience

• Neurokinin-2 receptor negatively modulates substance P responses by forming complex with Neurokinin-1 receptor

• NTR-1's Essential Contribution to Asymmetric Mating Between Two Sibling Nematode Species: Bursaphelenchus xylophilus and B. mucronatus

GPCRs in Oncology and Immunology

• GPCR signaling contributes to immune characteristics of microenvironment and process of EBV-induced lymphomagenesis

• GPR56 signaling pathway network and its dynamics in the mesenchymal transition of glioblastoma

Methods & Updates in GPCR Research

• Optogenetic Microwell Array Screening System: A High-Throughput Engineering Platform for Genetically Encoded Fluorescent Indicators

• Design of an effective small expression tag to enhance GPCR production in E. coli-based cell-free and whole cell expression systems

• A high-throughput structural dynamics approach for identification of potential agonists of FFAR4 for type 2 diabetes mellitus therapy

Industry News

• OMass Therapeutics Welcomes Melissa Faris as Chief Business Officer

• Septerna: Revitalizing G-Protein Coupled Receptor Drug Discovery

• Orion’s VP Drug Discovery, Dr. Oliver Hartley, was at the PEGS Europe

• Novartis pays Legend $100M upfront to give solid tumor CAR-T the T-Charge treatment

• Innovation And Healthcare Meet At Novartis

• Neurocrine Biosciences Announces Settlement of INGREZZA Abbreviated New Drug Application (ANDA) Litigation

• PostEra Announces a Research Collaboration with Amgen to Discover Small Molecule Therapeutics using Artificial Intelligence

• Novo Nordisk Invests 42 Billion Danish Kroner in New Manufacturing Facilities

• Addex ADX71149 Epilepsy Phase 2 Study Completes Recruitment of Patients

• Sanyou Bio's Evolution of Bioprocess Enhancement for CHO Cell Lines: A Talk by Dr. Meiling Lim

• TRUQAP™ (capivasertib) plus fulvestrant approved in the US for patients with advanced HR-positive breast cancer

GPCR Events, Meetings, and Webinars

• November 15 - 17, 2023 | MPGPCR Conference

• November 20 - 23, 2023 | ASCEPT Annual Scientific Meeting

• January 16 - 19, 2024 | 23rd Annual PEP Talk

• February 3 - 7, 2024 | SLAS2024 International Conference and Exhibition

• March 5 - 7, 2024 | 3rd GPCRs - Targeted Drug Discovery Summit

• March 23 - 24, 2024 | Ligand Recognition and Molecular Gating Seminar

• March 24 - 29, 2024 | Ligand Recognition and Molecular Gating Conference

• April 1 - 4, 2024 | 19th Annual Drug Discovery Chemistry

• NEW April 4 - 7, 2024 | American Physiology Summit

• April 5 - 10, 2024 | AACR Annual Meeting

• April 22 - 23, 2024 | Endocrine Metabolic GPCRs

• May 13 - 17, 2024 | 20th Annual PEGS Boston Summit

• May 16 - 19, 2024 | ASPET 2024

• May 27 - 29, 2024 | SLAS Europe 2024 Conference and Exhibition

• June 2 - 7, 2024 | Chemotactic Cytokines

• October 2 - 4, 2024 | 9th GPCRs in Medicinal Chemistry

• July 12 - 17, 2026 | 20th World Congress of Basic and Clinical Pharmacology 2026

GPCR Jobs

• NEW Sr Scientist in Obesity, Muscle, and Metabolism

• NEW Post-Doctoral Fellow

• NEW Research Associate I, Tissue Culture

• Post-Doc Research Associate

• Postdoctoral Fellow

• Research Scientist/Postdoctoral Associate in Computational Chemistry/Biophysics

• Post-Doctoral Associate

• Team Leader Antibody Discovery

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