📰 GPCR Weekly News, November 20 to 26, 2023

Hello GPCR people! We have great news! This week we’ve curated 18 GPCR papers, 1 new event, 9 industry news, and 3 job opportunities! Take a few minutes, and dive into our GPCR coverage!

We welcome GPCR paper suggestions! Submit your publications to Hello@DrGPCR.com for consideration.

This week's highlight:

• Thank you to Dr. Tobias Langenhan for his papers to highlight suggestions

  • GAIN Domain Unfolding in Adhesion GPCRs

  • Molecular Sensing in Adhesion GPCR Dissociation

  • Physiological Force Modulation in Drosophila Neurons
    

• Dr. David Gloriam and his team present GproteinDb in 2024

Are you looking to hire? Or maybe looking for your next opportunity? Let Mark Schmeizl, our Chief Matchmaker help. Contact him by filling out this form.

Our November Dr. GPCR Newsletter is now available. This month's video newsletter features Dr. Alix Rouault as our special guest. Subscribe now!

Don't miss the upcoming episodes of Dr.GPCR Podcast featuring Dr. Neil Grimsey and Dr. Katarzyna Marcinkiewicz.

Now check out the weekly Classified GPCR News from November 20th to 26th, 2023.

Adhesion GPCRs

• The Posttraumatic Increase in the Adhesion of GPCR EMR2/ ADGRE2 to Circulating Neutrophils Is Not Related to Injury Severity

• Unveiling Mechanical Activation: GAIN Domain Unfolding and Dissociation in Adhesion GPCRs

• Molecular sensing of mechano- and ligand-dependent adhesion GPCR dissociation

GPCR Activation and Signaling

• GPR101: Modeling a constitutively active receptor linked to X-linked acrogigantism

• The mechanism of Gαq regulation of PLCβ3-catalyzed PIP2 hydrolysis

GPCR Binders, Drugs, and more

• Discovery of Guanfacine as a Novel TAAR1 Agonist: A Combination Strategy through Molecular Modeling Studies and Biological Assays

GPCRs in Oncology and Immunology

• RGS5 maintaining vascular homeostasis is altered by the tumor microenvironment

• High Metabolite Concentrations in Portal Venous Blood as a Possible Mechanism for Microbiota Effects on the Immune System, and Western Diseases

• Lactate receptor GPR81 drives breast cancer growth and invasiveness through regulation of ECM properties and Notch ligand DLL4

• Chemokine N-terminal-derived peptides differentially regulate signaling by the receptors CCR1 and CCR5

• Chemokine Cxcl1-Cxcl2 heterodimer is a potent neutrophil chemoattractant

Methods & Updates in GPCR Research

• GproteinDb in 2024: new G protein-GPCR couplings, AlphaFold2-multimer models and interface interactions

• Experimental modulation of physiological force application on leg joint neurons in intact Drosophila melanogaster

Reviews, GPCRs, and more

• Catecholamine Derivatives: Natural Occurrence, Structural Diversity, and Biological Activity

• Advances in steroid research from the pioneering neurosteroid concept to metabolomics: New insights into pregnenolone function

• Molecular characterization of lumpy skin disease virus from recent outbreaks in Pakistan

Structural and Molecular Insights into GPCR Function

• Structural and signaling mechanisms of TAAR1 enabled preferential agonist design

• Proteome-wide structural analysis quantifies structural conservation across distant species

Industry News

• Avantor's (AVTR) New Offerings to Aid Cell and Gene Therapy Suite

• Avantor® Expands Cellular Science Offerings with Multispan Cell Engineering and Assay Services

• $3bn sales potential for drug Sosei Heptares wants back from GSK

• Novartis drops subpoena request in trade-secret spat with Takeda

• Novartis showcases significant data updates from Kisqali®, iptacopan and Scemblix® at SABCS and ASH

• Research reveals pro-phagocytic function and structural basis of GPR84 signaling

• Advancements in Precision Medicine: Superluminal Medicines Inc. Showcases Innovative AI-Driven Drug Design at BRIC AI 2023 Workshop

• Salipro Biotech AB Celebrates Milestones in CryoEM Structures and In Vitro Binding Assays Through Collaboration with Sanofi

• Genentech and NVIDIA Enter Into Strategic AI Research Collaboration to Accelerate Drug Discovery and Development

GPCR Events, Meetings, and Webinars

• January 16 - 19, 2024 | 23rd Annual PEP Talk

• February 3 - 7, 2024 | SLAS2024 International Conference and Exhibition

• NEW February 11 - 14, 2023 | 2024 BPS Annual Meeting

• March 5 - 7, 2024 | 3rd GPCRs - Targeted Drug Discovery Summit

• March 23 - 24, 2024 | Ligand Recognition and Molecular Gating Seminar

• March 24 - 29, 2024 | Ligand Recognition and Molecular Gating Conference

• April 1 - 4, 2024 | 19th Annual Drug Discovery Chemistry

• April 4 - 7, 2024 | American Physiology Summit

• April 5 - 10, 2024 | AACR Annual Meeting

• April 22 - 23, 2024 | Endocrine Metabolic GPCRs

• May 13 - 17, 2024 | 20th Annual PEGS Boston Summit

• May 16 - 19, 2024 | ASPET 2024

• May 27 - 29, 2024 | SLAS Europe 2024 Conference and Exhibition

• June 2 - 7, 2024 | Chemotactic Cytokines

• October 2 - 4, 2024 | 9th GPCRs in Medicinal Chemistry

• July 12 - 17, 2026 | 20th World Congress of Basic and Clinical Pharmacology 2026

GPCR Jobs - Contact Mark Schmeizl

• NEW Scientist

• NEW Lead Researcher

• NEW Post-Doctoral Fellow

• Sr Scientist in Obesity, Muscle, and Metabolism

• Post-Doctoral Fellow

• Research Associate I, Tissue Culture

• Post-Doc Research Associate

• Postdoctoral Fellow

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