📰 GPCR Weekly News, November 6 to November 12, 2023

Hi, everyone! This week, we've curated 12 GPCR papers. Plus, don't miss out on 6 upcoming events, 2 new job offers, and 9 industry updates. Let’s dive in!

Save the date:

• TOMORROW - November 17: Don't miss out on our final Dr. GPCR Symposium for the year, which will focus on GPCRs in Immunology and Oncology. A panel of top experts will be discussing this topic in a roundtable, starting at 10:00 AM EST. You can find more details about the speakers on the Live Talks page, and make sure to mark your calendar for this important event!

Discover the latest monthly Dr. GPCR Newsletter with Dr. Kathleen Caron, as our video guest, subscribe now!

Now check out the weekly Classified GPCR News from November 6th to 12th, 2023.

GPCR Activation and Signaling

• Neuronal survival factor TAFA2 suppresses apoptosis through binding to ADGRL1 and activating cAMP/PKA/CREB/BCL2 signaling pathway

• Deciphering specificity and cross-reactivity in tachykinin NK1 and NK2 receptors

GPCR Binders, Drugs, and more

• Discovery of (S)-3-(4-(benzyloxy)phenyl)-2-(2-phenoxyacetamido)propanoic acid derivatives as a new class of GPR34 antagonists

• Larixol is not an inhibitor of Gαi containing G proteins and lacks effect on signaling mediated by human neutrophil expressed formyl peptide receptors

• Molecular recognition of niacin and lipid-lowering drugs by the human hydroxycarboxylic acid receptor 2

GPCRs in Cardiology, Endocrinology, and Taste

• Lack of HCAR1, the lactate GPCR, signaling promotes autistic-like behavior

• Acetate mitigates cardiac mitochondrial dysfunction in experimental model of polycystic ovarian syndrome by modulating GPCR41/43 and PROKR1

GPCRs in Neuroscience

• Diverse signaling mechanisms and heterogeneity of astrocyte reactivity in Alzheimer's disease

GPCRs in Oncology and Immunology

• Context-dependent ciliary regulation of hedgehog pathway repression in tissue morphogenesis

• TIPE proteins control directed migration of human T cells by directing GPCR and lipid second messenger signaling

Methods & Updates in GPCR Research

• An image-based abplex method for high-throughput gpcrs antibody discovery

Reviews, GPCRs, and more

• Current strategic trends in drug discovery: the present as prologue

Industry News

• Exscientia Business Update for Third Quarter 2023

• Addex CEO Tim Dyer to Discuss Allosteric Modulators in Neurological Disorders at Jefferies Healthcare Conference in London

• Sosei Heptares and Kallyope Nominate First GPCR Target for Therapeutic Development in Gastrointestinal Diseases

• Sosei Heptares Operational Highlights and Consolidated Results for the Third Quarter and First Nine Months of 2023

• InterAx Biotech Announces Being the Recipient of a Highly Competitive European Grant to Fund Drug Development and Reports Financing Highlights

• Neurocrine Biosciences Provides Development Pipeline Update

• Crinetics Pharmaceuticals Announces November 2023 Inducement Grants Under Nasdaq Listing Rule 5635(c)(4)

• GPCR signaling contributes to immune characteristics of the microenvironment and the process of EBV-induced lymphomagenesis

• Tanso Biosciences: Core Technology for Our GPCR Functional Assay Patented in Japan

GPCR Events, Meetings, and Webinars

• November 15 - 17, 2023 | MPGPCR Conference

• November 20 - 23, 2023 | ASCEPT Annual Scientific Meeting

• NEW January 16 - 19, 2024 | 23rd Annual PEP Talk

• February 3 - 7, 2024 | SLAS2024 International Conference and Exhibition

• NEW March 5 - 7, 2024 | 3rd GPCRs - Targeted Drug Discovery Summit

• March 23 - 24, 2024 | Ligand Recognition and Molecular Gating Seminar

• March 24 - 29, 2024 | Ligand Recognition and Molecular Gating Conference

• NEW April 1 - 4, 2024 | 19th Annual Drug Discovery Chemistry

• April 5 - 10, 2024 | AACR Annual Meeting

• NEW April 22 - 23, 2024 | Endocrine Metabolic GPCRs

• May 13 - 17, 2024 | 20th Annual PEGS Boston Summit

• May 16 - 19, 2024 | ASPET 2024

• May 27 - 29, 2024 | SLAS Europe 2024 Conference and Exhibition

• June 2 - 7, 2024 | Chemotactic Cytokines

• NEW October 2 - 4, 2024 | 9th GPCRs in Medicinal Chemistry

• NEW July 12 - 17, 2026 | 20th World Congress of Basic and Clinical Pharmacology 2026

GPCR Jobs

• NEW Post-Doc Research Associate

• NEW Postdoctoral Fellow

• Research Scientist/Postdoctoral Associate in Computational Chemistry/Biophysics

• Post-Doctoral Associate

• Team Leader Antibody Discovery

• Staff Scientist (AC-TAP) in Database Development at Department of Drug Design and Pharmacology Faculty of Health and Medical Sciences

• Octant Apprentice

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