📰 GPCR Weekly News, October 9 to 15, 2023

Hi, everyone! Read about the newest discoveries in GPCR research 🙌

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• November 2 - 4: We're sponsoring the GPCR Retreat and would love to meet you there! Submit a logo design by Nov 1st on the Logo Contest page. No registration is needed to submit your logo design.

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Now check out the weekly Classified GPCR News from October 9th to 15th, 2023.

Adhesion GPCRs

• Piconewton Forces Mediate GAIN Domain Dissociation of the Latrophilin-3 Adhesion GPCR

• Unveiling Mechanical Activation: GAIN Domain Unfolding and Dissociation in Adhesion GPCRs

GPCR Activation and Signaling

• Diuretic hormone 31 activates two G protein-coupled receptors with differential second messengers for diuresis in Drosophila suzukii

• Beyond the G protein α subunit: investigating the functional impact of other components of the Gαi3 heterotrimers

• Activation/Deactivation Free-Energy Profiles for the β2-Adrenergic Receptor: Ligand Modes of Action

• A non-pheromone GPCR is essential for meiosis and ascosporogenesis in the wheat scab fungus

GPCR Binders, Drugs, and more

• Development of Photoswitchable Tethered Ligands that Target the µ-Opioid Receptor

• Design and Synthesis of Novel GPR139 Agonists with Therapeutic Effects in Mouse Models of Social Interaction and Cognitive Impairment

GPCRs in Neuroscience

• The Drosophila blood-brain barrier regulates sleep via Moody G protein-coupled receptor signaling

GPCRs in Oncology and Immunology

• Observational Study of Repeat Immunoadsorption (RIA) in Post-COVID ME/CFS Patients with Elevated ß2-Adrenergic Receptor Autoantibodies-An Interim Report

• GPR37 expression as a prognostic marker in gliomas: a bioinformatics-based analysis

Reviews, GPCRs, and more

• Parallel evolution of the G protein-coupled receptor GrlG and the loss of fruiting body formation in the social amoeba Dictyostelium discoideum evolved under low relatedness

Industry News

• Nobel Laureates Highlight Symposium Celebrating Lefkowitz’s 50 Years at Duke

• Novo Nordisk stops Ozempic kidney trial after early signs of success

• Sosei and PharmEnable extend neurological disease drugs hunt

• Sosei Heptares’ President & CEO Chris Cargill Wins Executive of the Year at the Citeline Pharma Intelligence Awards Japan 2023

• Salipro Biotech and Icosagen Launch Antibody Discovery Collaboration

• Cryo-EM in Drug Discovery

GPCR Events, Meetings, and Webinars

• NEW October 19, 2023 | ERNEST ECI Zoominar

• October 25 - 27, 2023 | 3rd Annual Meeting IRN I-GPCRNet

• November 2 - 4, 2023 | GPCR Retreat- Registration Closed

• November 15 - 17, 2023 | MPGPCR Conference

• November 20 - 23, 2023 | ASCEPT Annual Scientific Meeting

• February 3 - 7, 2024 | SLAS2024 International Conference and Exhibition

• March 23 - 24, 2024 | Ligand Recognition and Molecular Gating Seminar

• March 24 - 29, 2024 | Ligand Recognition and Molecular Gating Conference

• April 5 - 10, 2024 | AACR Annual Meeting

• May 13 - 17, 2024 | 20th Annual PEGS Boston Summit

• May 16 - 19, 2024 | ASPET 2024

• May 27 - 29, 2024 | SLAS Europe 2024 Conference and Exhibition

• June 2 - 4, 2024 | Chemotactic Cytokines

GPCR Jobs

• NEW Head of Human Resource Business Partners

• Senior Scientist, In vitro pharmacology - Crinetics Pharmaceuticals

• Senior Director, In vitro pharmacology - Crinetics Pharmaceuticals

• In vivo Antibody Discovery Research Scientist

• In Vitro Biologist/Molecular Pharmacologist

• Senior Vice President, Oncology Clinical Research

• Scientist (level I or II)

• Research Fellow

• Research Technician II - Surgery

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