📰 GPCR Weekly News, September 18 to 24, 2023

Hi readers! Take a few minutes and dive into our GPCR coverage!

Our recent Dr. GPCR Symposium about 'GPCRs as Therapeutic Modalities' rocked it! A huge thank you to our amazing speakers and everyone who showed up. If you couldn't make it, no sweat – our premium members can always go back and watch the recorded talks at any time here. For attendees, kindly spare a moment to complete our survey.

Save the dates:

• November 2 - 4: We're proud sponsors of the GPCR Retreat and can't wait to meet you there! Registration is now closed, but you can join the waitlist by emailing gpcrretreat@uottawa.ca. If you're already registered, kindly use the provided form to submit your poster abstracts. Short talk selections will be announced soon. Abstract submissions close on October 2nd. We are also looking for a new logo for this iconic event. Submit your logo design by November 1st. You don't need to be registered to participate. All information is available on the Logo Contest page.

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Dive into the Classified GPCR News from September 18th to 24th, 2023.

GPCR Activation and Signaling

• Rules and mechanisms governing G protein coupling selectivity of GPCRs

• Location-biased activation of the proton-sensor GPR65 is uncoupled from receptor trafficking

GPCR Binders, Drugs, and more

• An inverse agonist of orphan receptor GPR61 acts by a G protein-competitive allosteric mechanism

GPCRs in Cardiology, Endocrinology, and Taste

• Structural and functional analysis of salivary intercalated duct cells reveals a secretory phenotype

• Mesenchymal stromal cell secretory molecules improve the functional survival of human islets

• AT2 receptor agonist LP2 restores respiratory function in a rat model of bleomycin-induced lung remodelling

GPCRs in Neuroscience

• Photoactivatable Agonist-Antagonist Pair as a Tool for Precise Spatiotemporal Control of Serotonin Receptor 2C Signaling

GPCRs in Oncology and Immunology

• CaaX-motif-adjacent residues influence G protein gamma (Gγ) prenylation under suboptimal conditions

• Exploiting frequent and specific expression of PRL3 in pediatric solid tumors for first-in-child use of PRL3-zumab humanized antibody

• Activation of PI3K/Akt pathway by G protein-coupled receptor 37 promotes resistance to cisplatin-induced apoptosis in non-small cell lung cancer

Methods & Updates in GPCR Research

• Target immobilization on glass microfiber membranes as a label-free strategy for hit identification

Reviews, GPCRs, and more

• The discovery, structure, and function of 5-HTR1E serotonin receptor

Structural and Molecular Insights into GPCR Function

• Cryo-EM structures of human GPR34 enable the identification of selective antagonists

Industry News

• Inside the FDA's Form 483 findings at Novo Nordisk's North Carolina semaglutide plant

• Excellerate Bioscience Announces Site Relocation

• AI can help to speed up drug discovery — but only if we give it the right data

• Inversago Pharma divulges new cannabinoid CB1 receptor antagonists

• BenevolentAI, Exscientia on the comeback trail after securing separate AI drug discovery deals with Merck KGaA

• Pfizer’s Vydura recommended by NICE for acute migraines

• Addex mGlu2 NAM Cognition Program Receives €4 Million Grant

• Confo Therapeutics Appoints Stephen Dowd As Chief Business Officer

Call for GPCR Papers

• opnMe GPCR Route 66+ project. Deadline September 27, 2023

GPCR Events, Meetings, and Webinars

• October 2 - 3, 2023 | Celebrating Robert J. Lefkowitz's Career at Duke

• October 3, 2023, | FREE Seminar: Changing paradigm on Therapeutics targeting Membrane Proteins: from antigen production to candidate validation

• October 25 - 27, 2023 | 3rd Annual Meeting IRN I-GPCRNet

• November 2 - 4, 2023 | GPCR Retreat- Registration Closed

• November 15 - 17, 2023 | MPGPCR Conference

• November 20 - 23, 2023 | ASCEPT Annual Scientific Meeting

• February 3 - 7, 2024 | SLAS2024 International Conference and Exhibition

• March 23 - 24, 2024 | Ligand Recognition and Molecular Gating Seminar

• March 24 - 29, 2024 | Ligand Recognition and Molecular Gating Conference

• April 5 - 10, 2024 | AACR Annual Meeting

• May 13 - 17, 2024 | 20th Annual PEGS Boston Summit

• May 16 - 19, 2024 | ASPET 2024

• May 27 - 29, 2024 | SLAS Europe 2024 Conference and Exhibition

• June 2 - 4, 2024 | Chemotactic Cytokines

GPCR Jobs

• NEW Senior Vice President, Oncology Clinical Research

• NEW Scientist (level I or II)

• NEW Research Fellow

• Research Technician II - Surgery

• Post-Doc Research Associate

• Research Technician

• Senior Research Associate, In Vitro Pharmacology - Crinetics Pharmaceuticals

• Postdoc In Cell Biology Of Protein Trafficking

• Postdoctoral Fellow

Explore Dr. GPCR Ecosystem