📰 GPCR Weekly News, September 25 to October 1, 2023

Hello GPCR enthusiasts! Join us for our weekly GPCR round-up.

This week's highlights:

• Drs. Michel Bouvier, J Silvio Gutkind, and team found that Gαs is essential for GRK selectivity and gene regulation by β2-adrenergic receptor.

• Dr. Matthew Eddy and lab research on GPCR signaling mechanisms using NMR spectroscopy with labeled receptors.

Save the dates:

• November 2 - 4: We are excited to announce that we are sponsors of the GPCR Retreat and would love to meet you there! Unfortunately, registration has closed, but you can still join the waitlist by emailing gpcrretreat@uottawa.ca. In addition, we are currently seeking a new logo for this renowned event. You can submit your logo design by November 1st, and registration is unnecessary to participate. You can find all the necessary information on the Logo Contest page.

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And now, without further ado, dive into the latest Classified GPCR News from September 25th to October 1st, 2023.

GPCR Activation and Signaling

• The non-nutritive sweetener sucralose increases β-arrestin signaling at the constitutively active orphan G protein-coupled receptor GPR52

• β-Arrestin-independent endosomal cAMP signaling by a polypeptide hormone GPCR

• Gαs is dispensable for β-arrestin coupling but dictates GRK selectivity and is predominant for gene expression regulation by β2-adrenergic receptor

• Allosteric modulation of the fish taste receptor type 1 (T1R) family by the extracellular chloride ion

• Illuminating GPCR signaling mechanisms by NMR spectroscopy with stable-isotope labeled receptors

GPCR Binders, Drugs, and more

• Orthosteric ligand selectivity and allosteric probe dependence at Hydroxycarboxylic acid receptor HCAR2

• Antipsychotic displays dual GPCR binding mode

GPCRs in Cardiology, Endocrinology, and Taste

• An extracellular glucose sensor for substrate-dependent secretion and display of cellulose-degrading enzymes

• Functional Water Channels Within the TSH Receptor - a new paradigm for TSH action with disease implications

GPCRs in Oncology and Immunology

• LPA1-mediated inhibition of CXCR4 attenuates CXCL12-induced signaling and cell migration

• Respiratory infections predominate after day 100 following B-cell maturation antigen-directed CAR T-cell therapy

• SSTR2 positively associates with EGFR and predicts poor prognosis in nasopharyngeal carcinoma

• Unbiased multitissue transcriptomic analysis reveals complex neuroendocrine regulatory networks mediated by spinal cord injury-induced immunodeficiency

• G protein-coupled receptors: A target for microbial metabolites and a mechanistic link to microbiome-immune-brain interactions

Methods & Updates in GPCR Research

• Polyphosphate uses mTOR, pyrophosphate, and Rho GTPase components to potentiate bacterial survival in Dictyostelium

Reviews, GPCRs, and more

• Network pharmacology -based study on the mechanism of traditional Chinese medicine in the treatment of glioblastoma multiforme

Industry News

• Structure Therapeutics Announces Positive Results from Phase 1b Clinical Study of Oral GLP-1 Receptor Agonist GSBR-1290 and Provides Program Update

• Septerna sells GPCR program to Vertex for $48 million

• Merck KGgA collaborates with Exscientia plc in deal worth up to $674M

• 2023 Half-Year Financial Results and Exciting Developments at Aelis Farma

• Ion Channel Drug Developer Maxion Therapeutics Appoints Eva-Lotta Allan as Chair of its Board of Directors

• Novo Nordisk and Evotec collaborate to launch LAB eN², a translational drug discovery accelerator, to address innovation gap in cardiometabolic diseases

GPCR Events, Meetings, and Webinars

• October 2 - 3, 2023 | Celebrating Robert J. Lefkowitz's Career at Duke

• October 3, 2023, | FREE Seminar: Changing paradigm on Therapeutics targeting Membrane Proteins: from antigen production to candidate validation

• October 25 - 27, 2023 | 3rd Annual Meeting IRN I-GPCRNet

• November 2 - 4, 2023 | GPCR Retreat- Registration Closed

• November 15 - 17, 2023 | MPGPCR Conference

• November 20 - 23, 2023 | ASCEPT Annual Scientific Meeting

• February 3 - 7, 2024 | SLAS2024 International Conference and Exhibition

• March 23 - 24, 2024 | Ligand Recognition and Molecular Gating Seminar

• March 24 - 29, 2024 | Ligand Recognition and Molecular Gating Conference

• April 5 - 10, 2024 | AACR Annual Meeting

• May 13 - 17, 2024 | 20th Annual PEGS Boston Summit

• May 16 - 19, 2024 | ASPET 2024

• May 27 - 29, 2024 | SLAS Europe 2024 Conference and Exhibition

• June 2 - 4, 2024 | Chemotactic Cytokines

GPCR Jobs

• NEW In vivo Antibody Discovery Research Scientist

• NEW In Vitro Biologist/Molecular Pharmacologist

• Senior Vice President, Oncology Clinical Research

• Scientist (level I or II)

• Research Fellow

• Research Technician II - Surgery

• Post-Doc Research Associate

• Research Technician

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