Unlock the Future of GPCR Science: Breakthroughs and Courses Await | Sep 2 - Sep 8, 2024

Hello GPCR Enthusiasts,

Dive into this week's exciting updates on cutting-edge GPCR research, new learning opportunities, and industry news! Don't miss out—explore, learn, and elevate your expertise today!

Weekly Highlights:

Congrats to:

• Daniel Matúš, Simone Prömel, et al., for their work on The N terminus-only (trans) function of the Adhesion GPCR Latrophilin-1 controls multiple processes in reproduction of C. elegans
  

• Alexei Sirbu, Paolo Annibale, et al., for their study on Cell swelling enhances ligand-driven β-adrenergic signaling

  
  

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✨ Reserve Your seat before these fill up!

Our updated course schedule is designed to fit seamlessly into your routine, offering an enriched learning experience. Every Thursday at 10 AM EST:

• Principles of Pharmacology I

  • October 3, 10, 17, 24 (four sessions)

  • Topics: Pharmacologic activity measurement, mechanisms of action, and GPCR discovery strategies.
    

• Principles of Pharmacology II

  • October 31, November 7, 14, 21, December 5 (five sessions) (we skipped Thanksgiving, of course!)

  • Topics: New cellular assays, real-time kinetics, and unique GPCR behaviors.

🔥 Why You Should Enroll Now:

Act Fast & Save Big!

• The Principles of Pharmacology I & II BUNDLE is your key to mastering the field. You can embrace a 25% OFF early bird discount as a premium member. But act fast – this offer is only available for a limited time.
  

• Not a premium member yet? No problem – we offer a 5-day FREE trial! And access over 500 minutes of recorded classes in our GPCR courses with Drs. Terry Kenakin and Sam Hoare!

Affordable & Unique Learning Experience

• Our budget-friendly courses offer a unique approach to mastering pharmacology.
  

Flexible Learning

• Rewatch sessions anytime to reinforce your learning.

Our Students Love Us!

• Past students rave about the content and service of our courses.

Save Your Spot Today!

Join us for an exciting discussion with Dr. Terry Kenakin as he shares insights into what you can anticipate for the upcoming courses. Don't miss this fantastic opportunity to gain valuable knowledge and prepare for the forthcoming sessions!

Exclusive Deal for Scientists Residing and Working in Developing Nations

If you live and work in a developing country, please complete this form to enjoy complimentary access to Dr. Kenakin's upcoming courses. Our goal is to ensure that education is within reach for everyone!

Secure your spot today and dive into the evolving world of GPCRs!

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GPCR Event Spotlight

Discovery on Target’s 19th Annual GPCR-Based Drug Discovery

Targeting G Protein-Coupled Receptors for New Therapeutic Options

📍 Boston, MA

📅 October 2 -3, 2024

Join top researchers to explore the latest in GPCR-targeted drug design, including machine learning, new biophysical techniques, and medicinal chemistry.

Register today for the GPCR Drug Discovery Conference and save $200 with discount code “DRGPCR24”.

11th Adhesion GPCR Workshop  

📍 Mexico City

📅 October 23-25, 2024

Connect with your colleagues and immerse yourself in the most recent advancements in adhesion GPCR biology. Stay tuned for the release of the full agenda!

Are you interested in boosting your brand? Contact us at Hello@DrGPCR.com for sponsorship opportunities.

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Classified GPCR News

 Let’s dive into the Classified GPCR News from September 2nd to 8th, 2024

Industry News

• Superluminal Medicines Closes $120 Million Series A Round

• Domain Therapeutics has been nominated for Prix Galien USA

• Carterra unveils its most sensitive biosensor platform; Carterra Ultra™ ushers in a new frontier in fragment and small molecule drug discovery

• Is the pharma community looking hard enough before trying to engage highly challenging neurology targets? Engaging multiple sclerosis by drugging a “simple” GPCR.

• This technique for studying cell receptors could have sweeping implications for drug development

• DeepCure team is excited to welcome Justin Potnick, to our Medicinal Chemistry group
  

Call for GPCR Papers

• Emerging Voices in GPCR Biology in Special Issue of Molecular Pharmacology

GPCR Events, Meetings, and Webinars

• September 5 - 6, 2024 | 4th Transatlantic ECI GPCR Symposium

• September 18, 2024 | FREE Webinar - The value of GPCR cell-based assays in drug discovery

• NEW September 22, 2024 | Biomolecular Horizons 2024

• September 30 - October 3, 2024 | 22nd Discovery on Target

• October 2024 | Biologics US 2024 

• October 2 - 4, 2024 | 9th GPCRs in Medicinal Chemistry

• October 17, 2024 | Unprecedented fragment-based screening using Spectral Shift for GPCRs

• October 23 - 25, 2024 | 11th Adhesion GPCR Workshop

• November 5 - 7, 2024 | 16th Annual PEGS Europe 

• NEW November 26 - 28, 2024 | GPCRs-Targeted Drug Discovery Summit Europe

• July 12 - 17, 2026 | 20th World Congress of Basic and Clinical Pharmacology

GPCR Jobs

• HIGHLIGHT Research Associate - Professor Graeme Milligan

• HIGHLIGHT Postdoc in Molecular Pharmacology - The Hauser Group

• Senior Scientist/Staff Scientist, Computational Chemistry

• Postdoc in GPCR mechanosensing 

• Postdoctoral Position

• Postdoctoral research position

Adhesion GPCRs

• The N terminus-only (trans) function of the Adhesion GPCR Latrophilin-1 controls multiple processes in reproduction of C. elegans

• The G protein-coupled receptor ADGRG6 maintains mouse growth plate homeostasis through IHH Signaling

GPCR Activation and Signaling

• Illuminating GPCR trafficking

• Cell swelling enhances ligand-driven β-adrenergic signaling

• Roles of the gate loop in β-arrestin-1 conformational dynamics and phosphorylated receptor interaction

• Early Events in β2AR Dimer Dynamics Mediated by Activation-Related Microswitches

• Nuclear translocation of the membrane oxoeicosanoid/androgen receptor, OXER1: Possible mechanisms involved

• An engineered trafficking biosensor reveals a role for DNAJC13 in DOR downregulation

GPCRs in Cardiology, Endocrinology, and Taste

• Role of G protein coupled receptors in acute kidney injury

• Ligand-Dependent and G Protein-Dependent Properties for the Sweet Taste Heterodimer, TAS1R2/1R3

GPCRs in Neuroscience

• GPCR-Mediated Natural Products and Compounds: Potential Therapeutic Targets for the Treatment of Neurological Diseases

• Activation of GPR55 alleviates neuropathic pain and chronic inflammation

• Developmental exposures to common environmental pollutants result in long-term Reprogramming of hypothalamic-pituitary axis in mice

GPCRs in Oncology and Immunology

• A disturbed metabolite-GPCR axis is associated with microbial dysbiosis in IBD patients: Potential role of GPR109A in macrophages

Structural and Molecular Insights into GPCR Function

• Insights into the structure and activation mechanism of some class B1 GPCR family members

• Structural basis of Frizzled 4 in recognition of Dishevelled 2 unveils mechanism of WNT signaling activation

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