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Thank you for your interest in the Applying Pharmacology to Drug Discovery course with Dr. GPCR University. All spots in the course are now filled. To join our waitlist please fill out this form - https://forms.gle/xPZjX56LkEvhGv6b6 We'll let you know if any spots become available. Thank you for your understanding and enthusiasm! ----------------------------------------------------------------------------------------------------- The main objective of this course is to give the registrant a good overall understanding of the unique science of pharmacology and how it can describe drug action in system-independent ways. This allows predictions of drug activity in all physiological systems, not only the system where testing is done. Techniques will be described to quantify drug activity in terms of affinity, efficacy, and allosteric function. Pharmacology is a unique discipline and is critical to drug discovery. Registrants will learn: 1. Methods to characterize the 3 major drug types. 2. What makes each drug type unique to therapeutic pharmacology? 3. Essential information needed to characterize the profile of a drug aimed at therapy. Modules: Week 1 - Fundamentals of Pharmacology Week 2 - Characterizing Agonists Week 3 - Characterizing Antagonists Week 4 - Characterizing Allosteric Modulators Registrations start on December 15th and close on February 2nd. Classes will be live from Zoom on Thursdays from 10 am to 11:30 am EST. Sessions will include a 1-hour live lecture plus 30 minutes of Q&A. Every participant will also get the chance to have a 1:1 meeting with Dr. Kenakin during the 4 weeks, scheduled according to the professor's availability. Participants who complete the course will get an online certification signed by the professor and the Dr.GPCR Team. A splendid time is guaranteed for all.

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Ho, ho, ho, GPCR elves! As the year wraps up, we're thrilled to present the final edition of the GPCR Weekly Newsletter for 2024! As researchers, we all understand the importance of data in driving meaningful discoveries  and advancing our experiments.   At Dr. GPCR, we believe the same principle applies to building a better experience  for our online community.   We’d love to hear your thoughts on our website and its features  so that we can continue to support your work and foster collaborations in the GPCR field.   Your feedback  will guide us in tailoring resources , tools , and content to meet your needs better and help fuel your research. Thank you for sharing your perspective and helping us shape the future of the Dr. GPCR ecosystem! Best, Yamina & the Dr. GPCR Team This Week’s Highlights: Congratulations to Andrew Tobin for an incredible week filled with prestigious events, including receiving the British Pharmacological Society Vane Medal and switching on the Christmas lights at the University of Glasgow Advanced Research Centre! Activation of the proton-sensing GPCR, GPR65 on fibroblast-like synoviocytes contributes to inflammatory joint pain Luke A Pattison , Rebecca H Rickman , Graham Ladds , Ewan St John Smith , et al. Attention, everyone! This is your last chance before the curtain closes: Classified GPCR News will be accessible only to VIP members next year! Indeed, all the details below will be limited to Premium Members . Don't miss out—upgrade now to keep up with your GPCR updates! Classified GPCR News  Let’s dive into the   Classified GPCR News from December 9th to 15th, 2024 Industry News When science meets serendipity: How accidental discoveries could revolutionise women’s health Seven unanswered questions about blockbuster weight-loss drugs Transforming Drug Discovery: Insights from Viva Biotech's GPCR and TPD Structural Biology Platforms GPCR Events, Meetings, and Webinars December 10 - 12, 2024 | Pharmacology 2024 January 13 - 16, 2025 | PepTalk 2025 January 25 - 29, 2025 | SLAS 2025 February 15 - 16, 2025 | Structural and Functional Approaches in GPCR Drug Discovery February 15 - 19, 2025 | BPS 2025 February 16 - 21, 2025 | Harnessing the Power of Advanced Multimodal Approaches to GPCR Drug Discovery March 12 - 14, 2025 | NextGen Biomed 2025 March 25 - 28, 2025 | 10th German Pharm-Tox Summit April 1 - 5, 2025 | XXIII GEM Meeting in 2025 April 3 - 6, 2025 | ASPET 2025 April 14 - 17, 2025 | 20th Drug Discovery Chemistry April 24 - 27, 2025 | American Physiology Summit 2025 April 25 - 30, 2025 | AACR Annual Meeting 2025 May 12 - 15, 2025 | PEGS 2025 May 20 - 22, 2025 | SLAS Europe 2025 June 16 - 19, 2025 | BIO International Convention 2025 July 12 - 17, 2026 | 20th World Congress of Basic and Clinical Pharmacology GPCR Jobs GPCR Molecular Pharmacologist Scientist - Biology Scientist I Cell Biology - Tectonic Therapeutic Senior Principal Scientist, Medicinal Chemistry PhD fellowship in GPCR mechanosensing Senior Scientist, GPCR Pharmacology Research Associate - Professor Graeme Milligan Postdoc in Molecular Pharmacology - The Hauser Group Postdoctoral Scholar – iPSC in cardiac and endothelial cell function Protein Biochemist/Structural Biologist GPCR Activation and Signaling Activation of the proton-sensing GPCR, GPR65 on fibroblast-like synoviocytes contributes to inflammatory joint pain Regulation of the chemokine receptors CXCR4 and ACKR3 by receptor activity-modifying proteins Single-cell transcriptomics of vomeronasal neuroepithelium reveals a differential endoplasmic reticulum environment amongst neuronal subtypes Methods & Updates in GPCR Research High-throughput optimisation of protein secretion in yeast via an engineered biosensor Optimized vector for functional expression of the human bitter taste receptor TAS2R14 in HEK293 cells Reviews, GPCRs, and more The role of the endocannabinoid system in the pathogenesis and treatment of epilepsy Become a Premium Member! Get your 5-day free trial TODAY!

Hello, hello GPCR Buddies! It's starting to look a lot like Christmas at Dr. GPCR! We've got an early holiday treat for you: The University CheatSheet ! Dive into our courses, talks, poster presentations, and more! This Week’s Highlights: Congratulations to our amazing Board Member JoAnn Trejo for being elected to the British Pharmacological Society Honorary Fellowship! 🎉 Conformational coupling between extracellular and transmembrane domains modulates holo-adhesion GPCR function Szymon P Kordon , Kristina Cechova , Sumit J Bandekar , Demet Araç , et al. Structure-guided design of a peripherally restricted chemogenetic system Hye Jin Kang , Brian E Krumm , Adrien Tassou , Bryan L Roth , et al. 🕶 University CheatSheet is here! We are thrilled to announce that we've been working tirelessly to bring you a simple, beautiful, and insightful collection of all our content! Dive into a world of knowledge where you can search by topics and events . As a Premium Member, you gain exclusive access to this incredible treasure trove we've amassed over the years, featuring excellent speakers from around the globe. We are bursting with pride in sharing it with you, and we sincerely want to thank you for your support over the years. We are ecstatic to create a space where the GPCR Community can thrive with information and INSPIRATION! Listen up, folks! This is your last call before the curtain drops: Classified GPCR News is going VIP-only next year! That's right, all the tidbits below will be for Premium Members ' eyes only. Don't get left in the dust—upgrade now and keep your GPCR gossip game strong! Classified GPCR News  Let’s dive into the   Classified GPCR News from December 2nd to 8th, 2024 Industry News 2024 Fellows and Honorary Fellows announced Nxera Pharma Enrolls First Insomnia Patient in its Phase 3 Clinical Trial of Daridorexant in South Korea Septerna Touches New High, To Report SEP-786 Data In Mid-2025 How GPCR agonists, including antibodies, are shaping the future of metabolic care Salipro Biotech Expands Global Intellectual Property Portfolio with Granted Patents in Australia and Singapore Crinetics Announces FDA Acceptance of New Drug Application for Paltusotine for Adult Patients with Acromegaly GPCR Events, Meetings, and Webinars December 10 - 12, 2024 | Pharmacology 2024 January 13 - 16, 2025 | PepTalk 2025 January 25 - 29, 2025 | SLAS 2025 February 15 - 16, 2025 | Structural and Functional Approaches in GPCR Drug Discovery February 15 - 19, 2025 | BPS 2025 February 16 - 21, 2025 | Harnessing the Power of Advanced Multimodal Approaches to GPCR Drug Discovery March 12 - 14, 2025 | NextGen Biomed 2025 March 25 - 28, 2025 | 10th German Pharm-Tox Summit April 1 - 5, 2025 | XXIII GEM Meeting in 2025 April 3 - 6, 2025 | ASPET 2025 April 14 - 17, 2025 | 20th Drug Discovery Chemistry April 24 - 27, 2025 | American Physiology Summit 2025 April 25 - 30, 2025 | AACR Annual Meeting 2025 May 12 - 15, 2025 | PEGS 2025 May 20 - 22, 2025 | SLAS Europe 2025 June 16 - 19, 2025 | BIO International Convention 2025 July 12 - 17, 2026 | 20th World Congress of Basic and Clinical Pharmacology GPCR Jobs GPCR Molecular Pharmacologist Scientist - Biology Scientist I Cell Biology - Tectonic Therapeutic Senior Principal Scientist, Medicinal Chemistry PhD fellowship in GPCR mechanosensing Senior Scientist, GPCR Pharmacology Research Associate - Professor Graeme Milligan Postdoc in Molecular Pharmacology - The Hauser Group Postdoctoral Scholar – iPSC in cardiac and endothelial cell function Protein Biochemist/Structural Biologist Adhesion GPCRs Conformational coupling between extracellular and transmembrane domains modulates holo-adhesion GPCR function GPCR Activation and Signaling P2X7R-primed keratinocytes are susceptible to apoptosis via GPCR-Gβγ-pERK signal pathways Chemogenetic engagement of different GPCR signaling pathways segregates the orexigenic activity from the control of whole-body glucose metabolism by AGRP Neurons Fast-diffusing receptor collisions with slow-diffusing peptide ligand assemble the ternary parathyroid hormone-GPCR-arrestin complex Myosin VI drives arrestin-independent internalization and signaling of GPCRs Corticotropin-releasing factor-like diuretic hormone 44 and five corresponding GPCRs in Drosophila suzukii: Structural and functional characterization Distribution and calcium signaling function of somatostatin receptor subtypes in rat pituitary Synthetic GPCRs for programmable sensing and control of cell behaviour GPCR Binders, Drugs, and more Exploring potential GPR55 agonists using virtual screening, molecular docking and dynamics simulation studies GPCRs in Neuroscience Neuronal cell populations in circumoral nerve ring of sea cucumber Apostichopus japonicus: Ultrastructure and transcriptional profile Adult single-nucleus neuronal transcriptomes of insulin signaling mutants reveal regulators of behavior and learning GPCRs in Oncology and Immunology Short-chain fatty acids and cancer The path of GPR87: from a P2Y-like receptor to its role in cancer progression Ascitic Shear Stress Activates GPCRs and Downregulates Mucin 15 to Promote OvarianCancer Malignancy Bispecific antibodies targeting BCMA or GPRC5D are highly effective in relapsed myeloma after CAR T-cell therapy Methods & Updates in GPCR Research Structure-guided design of a peripherally restricted chemogenetic system Structural and Molecular Insights into GPCR Function AlphaFold3 versus experimental structures: assessment of the accuracy in ligand-bound G protein-coupled receptors Molecular insights into the activation mechanism of GPR156 in maintaining auditory function Become a Premium Member! 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Grab your flux capacitors, GPCR time travelers! We're zooming back to the future of GPCR discoveries. Buckle up as we time-hop through this week's GPCR escapade! This Week’s Highlights: G protein-coupled receptor (GPCR) pharmacogenomics Miles D Thompson , David Reiner-Link , Alessandro Berghella , Brinda K Rana , G Enrico Rovati , Valerie Capra , Caroline M Gorvin , Alexander S Hauser Calcineurin-fusion facilitates cryo-EM structure determination of a Family A GPCR Jun Xu , Geng Chen , Haoqing Wang , Sheng Cao , Jie Heng , Xavier Deupi , Yang Du , Brian K Kobilka Red and far-red cleavable fluorescent dyes for self-labelling enzyme protein tagging and interrogation of GPCR co-internalization Kilian Roßmann , Ramona Birke , Joshua Levitz , Ben Jones , Johannes Broichhagen Design of allosteric modulators that change GPCR G protein subtype selectivity   Madelyn N Moore , Kelsey L Person , Abigail Alwin , Campbell Krusemark , Ezequiel Marron Fernandez de Velasco , Steven H Olson , Lauren M Slosky , et. al. Discover the DrGPCR Ecosystem! Our Ecosystem provides an impressive array of platforms tailored for GPCR students and professionals in industry and academia, offering unparalleled connections and opportunities. To fully explore our Ecosystem, scroll to the footer and check out our Map! To truly maximize your experience, you MUST get our Premium Membership and begin taking advantage of our exceptional features: Dr. GPCR University 🎥 Recorded GPCR Courses and Symposia / Summit 💲 Special Pricing on GPCR courses GPCR Forum Start a lively chat or request help with your research! GPCR Events Mark your glittery calendar with dates in 2025 ! GPCR Jobs Seeking a job or the perfect employee? Book a date with our Chief Match Maker! Direct line to the Dr. GPCR community members Join the GPCR fan club and geek out with fellows! So much more to come! 🕵️‍♂️ Get ready to crack the code, folks! We're about to reveal our University CheatSheet —a sneaky peek at all our talks, presentations, and courses. It's like having a treasure map to academic success! Please don't say we didn't give you a heads-up! Starting in 2025, only Premium Members can access Classified GPCR News. This change is all about keeping our community strong and delivering top-notch content. It'll help us keep things running smoothly and grow our community. Thanks for understanding and supporting us! Classified GPCR News  Let’s dive into the   Classified GPCR News from November 25th to December 1st, 2024 Industry News Amgen says obesity drug caused up to 20% weight loss after a year, with no plateau INAUGURATION OF AELIS FARMA NEW LABORATORY at Institut Européen de Chimie et Biologie (IECB) in Pessac (Bordeaux) AI-Powered Drug Discovery and Antibody Innovation: DeciBio Q&A with Sean McClain, Founder & CEO, and Zach Jonasson, CFO & CBO at Absci Octant: A Next Generation Approach to Genetic Disease Antiverse, Nxera Pharma Teams to Unleash Machine Learning on Elusive Biological Keys to Medical Therapies From Structure to Solution: How Structural Biology Informs the Development of Drugs Targeting G Protein-Coupled Receptors ARTICA THERAPEUTICS ANNOUNCES ESTABLISHMENT OF SCIENTIFIC ADVISORY BOARD GPCR Events, Meetings, and Webinars December 10 - 12, 2024 | Pharmacology 2024 January 13 - 16, 2025 | PepTalk 2025 January 25 - 29, 2025 | SLAS 2025 February 15 - 16, 2025 | Structural and Functional Approaches in GPCR Drug Discovery February 15 - 19, 2025 | BPS 2025 February 16 - 21, 2025 | Harnessing the Power of Advanced Multimodal Approaches to GPCR Drug Discovery March 12 - 14, 2025 | NextGen Biomed 2025 March 25 - 28, 2025 | 10th German Pharm-Tox Summit April 1 - 5, 2025 | XXIII GEM Meeting in 2025 April 3 - 6, 2025 | ASPET 2025 April 14 - 17, 2025 | 20th Drug Discovery Chemistry April 24 - 27, 2025 | American Physiology Summit 2025 April 25 - 30, 2025 | AACR Annual Meeting 2025 May 12 - 15, 2025 | PEGS 2025 May 20 - 22, 2025 | SLAS Europe 2025 June 16 - 19, 2025 | BIO International Convention 2025 July 12 - 17, 2026 | 20th World Congress of Basic and Clinical Pharmacology GPCR Jobs NEW GPCR Molecular Pharmacologist Scientist - Biology Scientist I Cell Biology - Tectonic Therapeutic Senior Principal Scientist, Medicinal Chemistry PhD fellowship in GPCR mechanosensing Senior Scientist, GPCR Pharmacology Research Associate - Professor Graeme Milligan Postdoc in Molecular Pharmacology - The Hauser Group Postdoctoral Scholar – iPSC in cardiac and endothelial cell function Protein Biochemist/Structural Biologist GPCR Activation and Signaling Exploring Bias in GPCR Signaling and its Implication in Drug Development: A One-Sided Affair Agonist activation to open the Gα subunit of the GPCR-G protein precoupled complex defines functional agonist activation of TAS2R5 Biased activation of the vasopressin V2 receptor probed by molecular dynamics simulations, NMR and pharmacological studies High-affinity ELR+ chemokine ligands show G protein bias over β-arrestin recruitment and receptor internalization in CXCR1 signalling GPCR Binders, Drugs, and more G protein-coupled receptor (GPCR) pharmacogenomics Antibodies expand the scope of angiotensin receptor pharmacology Chimeric antigens displaying GPR65 extracellular loops on a soluble scaffold enabled the discovery of antibodies, which recognized native receptor Design of allosteric modulators that change GPCR G protein subtype selectivity GPCRs in Cardiology, Endocrinology, and Taste Integrated bioinformatics analysis reveals that CCBP2 and GPR87 are new GPCR-associated biomarkers for preeclampsia Metabolic control of Luteinizing Hormone-responsive ovarian steroidogenesis Cardiovascular Complications and Their Association With Short- and Long-Term Outcomes in Patients With Multiple Myeloma and Lymphoma Undergoing Chimeric Antigen Receptor T-Cell Therapy GPCRs in Neuroscience Innervation density governs crosstalk of GPCR-based norepinephrine and dopamine sensors Intranasal delivery of liposome encapsulated flavonoids ameliorates l-DOPA induced dyskinesia in hemiparkinsonian mice GPR88 impairs the signaling of kappa opioid receptors in a heterologous system and in primary striatal neurons GPCRs in Oncology and Immunology Protease-Activated Receptor-1 IgG Autoantibodies in Patients with COVID-19 Signaling by neutrophil G protein-coupled receptors that regulate the release of superoxide anions SSTR2 positively associates with EGFR and predicts poor prognosis in nasopharyngeal carcinoma RNAi library screening reveals Gβ1, Casein Kinase 2 and ICAP-1 as novel regulators of LFA-1-mediated T cell polarity and migration Methods & Updates in GPCR Research Calcineurin-fusion facilitates cryo-EM structure determination of a Family A GPCR Red and far-red cleavable fluorescent dyes for self-labelling enzyme protein tagging and interrogation of GPCR co-internalization AlloViz: A tool for the calculation and visualisation of protein allosteric communication networks GPTrans: A Biological Language Model-Based Approach for Predicting Disease-Associated Mutations in G Protein-Coupled Receptors Structural and Molecular Insights into GPCR Function Inhibitory effect of truncated isoforms on GPCR dimerization predicted by combinatorial computational strategy Uncovering conserved networks and global conformational changes in G protein-coupled receptor kinases The membrane domains of mammalian adenylyl cyclases are lipid receptors Structural insights into endogenous ligand selectivity and activation mechanisms of FFAR1 and FFAR2 Become a Premium Member! 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Join our exciting online event to ignite your passion for GPCR! Renowned speakers will inspire you with their stories and innovative research. Connect with like-minded individuals, exchange ideas, and embrace the future of GPCR together! All Symposia Events are: 1. Virtual 2. Re-watchable for Premium Members 3. Recent Advances in GPCR Research 4. Networking GPCR Activation and Signaling March 15th, 2024 GPCRs in Immunology and Oncology November 17, 2023 GPCRs as Therapeutic Modalities September 22, 2023 Structural and Molecular Insights into GPCR Activation July 21, 2023 GPCR Activation and Signaling May 19, 2023 Recent Advances in Understanding Challenging GPCRs March 24, 2023 SymposiaPrice Premium Monthly $ 24.99 24.99$ Every month Immerse yourself into the GPCR World 5 day free trial Start Free Trial Live and Recorded Courses Exclusive access to early bird special Access to previous events recordings Premium Yearly $ 249.99 249.99$ Every year Immerse yourself into the GPCR World 5 day free trial Start Free Trial Live and Recorded Courses Exclusive access to early bird special Access to previous events recordings Become Dr. GPCR Strategic Partner

Advanced data analysis for GPCR pharmacology Dr. Samuel Hoare On Demand 4 modules - 8 hours total Get Started Premium Members benefits: - Subscribe and save 25% on every GPCR Course - Early-bird access - Recordings will be available < Back to GPCR courses Main objectives: Learning how to perform advanced GPCR pharmacology data analysis in support of drug discovery and GPCR research, shown with GraphPad Prism. Understanding the pharmacology data analysis framework we use for GPCRs. Appreciating the practical realities, limitations, and tradeoffs of GPCR data analysis. Learning many tips and tricks to improve your data analysis's quality, reliability, and efficiency. The participants will increase their ability to perform, understand, and communicate GPCR pharmacology data analysis to a high level, as well as expertise that can be applied in drug discovery and target research to maximize the chances of project success. The increased understanding will also be helpful for the participants in their training and education of entry-level scientists. Attendees will be provided with Prism files, Excel templates and simulators, and the PowerPoints of the workshop modules. Modules: Module 1 - Concentration-response analysis: Become a CRC super-user. Module 2 - Quantifying agonist pharmacology and biased agonism. Module 3 - Antagonist pharmacology and binding assay analysis. Module 4 - New dimensions of activity: Allosteric modulators and kinetics. Good to know: Classes will be live from Zoom on Thursdays from 10 am to 12:00 pm EST. Sessions will include a one-hour live lecture plus one hour of Q&A and discussion. Every participant will also have a 1:1 meeting with Dr. Hoare during or after the four weeks, scheduled according to the professor's availability. Participants who complete the course will get an online certification signed by the professor and the Dr.GPCR Team. Watch the recordings *Free for Premium Members Watch recording Your Instructor Dr. Samuel Hoare Sam Hoare is a pharmacology data analyst with 30 years experience in GPCR pharmacology. He consults with numerous pharmaceutical, biotech, life science and academic organizations in understanding and applying in vitro pharmacology data to advance drug discovery and target research. He regularly teaches courses and publishes chapters and guides on basic and advanced pharmacology and experimental design. Sam is an editor at the NIH Assay Guidance Manual. Sam specializes in kinetic analysis of drug action and is known for applying binding and signaling kinetics to the development of effective therapeutics. He worked as a pharmacology leader in the pharmaceutical industry for 15 years at Neurocrine Biosciences, guiding the in vitro biology efforts for numerous drug discovery campaigns. He completed his Ph.D. in biochemistry, studying allosteric modulation of dopamine receptors, from the University of Kent in the United Kingdom. He completed postdoctoral training at the National Institute of Mental Health, researching the pharmacological mechanisms of Class B GPCRs.

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