Search Results
494 items found for "Bcl-2"
- The regulation of PKA signaling in obesity and in the maintenance of metabolic health
October 2022 "The cAMP-dependent protein kinase (PKA) system represents a primary cell-signaling pathway
- G protein-biased GPR3 signaling ameliorates amyloid pathology in a preclinical Alzheimer's disease..
October 2022 "Biased G protein-coupled receptor (GPCR) ligands, which preferentially activate G protein
- The microglial endocannabinoid system similarly regulated by lipopolysaccharide and interferon gamma
October 2022 "Perturbation of the endocannabinoid system can have profound effects on immune function
- Label-free LC-MS based assay to characterize small molecule compound binding to cells
October 2022 "Study of small molecule binding to live cells provides important information on the characterization
- Bell-Evans model and steered molecular dynamics in uncovering the dissociation kinetics of ligands..
October 2022 Bell-Evans model and steered molecular dynamics in uncovering the dissociation kinetics
- Glucagon receptor-mediated regulation of gluconeogenic gene transcription is endocytosis-dependent..
October 2022 Glucagon receptor-mediated regulation of gluconeogenic gene transcription is endocytosis-dependent
- Design and validation of recombinant protein standards for quantitative Western blot analysis of...
October 2022 Design and validation of recombinant protein standards for quantitative Western blot analysis
- The complicated lives of GPCRs in cardiac fibroblasts
October 2022 "The role of different G protein-coupled receptors (GPCRs) in the cardiovascular system
- The Adhesion GPCR VLGR1/ADGRV1 Regulates the Ca2+ Homeostasis at Mitochondria-Associated ER Membrane
October 2022 "The very large G protein-coupled receptor (VLGR1, ADGRV1) is the largest member of the
- Lysosomal GPCR-like protein LYCHOS signals cholesterol sufficiency to mTORC1
October 2022 "Lysosomes coordinate cellular metabolism and growth upon sensing of essential nutrients
- Production of human A2AAR in lipid nanodiscs for 19F-NMR and single-molecule fluorescence...
October 2022 "We describe production of the human A2A adenosine receptor (A2AAR), a class A G protein-coupled For complete details on the use and execution of this protocol, please refer to Wei et al. (2022) and Sušac et al. (2018)."
- Comparative studies of AlphaFold, RoseTTAFold and Modeller: a case study involving the use of...
October 2022 Comparative studies of AlphaFold, RoseTTAFold and Modeller: a case study involving the use looking at each program's top-scored structure, Modeller had the smallest average modeling RMSD of 2.17 However, the NN-based methods (AlphaFold and RoseTTAFold) outperformed Modeller in 21 and 15 out of the
- Mechanistic Understanding of the Palmitoylation of Go Protein in the Allosteric Regulation of...
October 2022 Mechanistic Understanding of the Palmitoylation of Go Protein in the Allosteric Regulation
- Diversification of PAR signaling through receptor crosstalk
October 2022 "Protease activated receptors (PARs) are among the first receptors shown to transactivate
- Dopamine activates astrocytes in prefrontal cortex via α1-adrenergic receptors
October 2022 "The prefrontal cortex (PFC) is a hub for cognitive control, and dopamine profoundly influences
- PH-Binding Motif in PAR4 Oncogene: From Molecular Mechanism to Drug Design
October 2022 "While the role of G-protein-coupled receptors (GPCR) in cancer is acknowledged, their underlying
- N-Acyl Amides from Neisseria meningitidis and Their Role in Sphingosine Receptor Signaling
October 2022 "Neisseria meningitidis is a Gram-negative opportunistic pathogen that is responsible for
- Single-molecule counting applied to the study of GPCR oligomerization
October 2022 "Single-molecule counting techniques enable a precise determination of the intracellular
- Network pharmacological investigation into the mechanism of Kaixinsan powder for the treatment of...
October 2022 Network pharmacological investigation into the mechanism of Kaixinsan powder for the treatment
- A cryptic mode of GPCR regulation revealed
October 2022 "Over three decades of research have provided thorough insights into G protein-coupled receptor
- Viral G Protein-Coupled Receptors Encoded by β- and γ-Herpesviruses
October 2022 "Herpesviruses are ancient large DNA viruses that have exploited gene capture as part of
- Mechanism of enhanced sensitivity of mutated β-adrenergic-like octopamine receptor to amitraz in...
October 2022 Mechanism of enhanced sensitivity of mutated β-adrenergic-like octopamine receptor to amitraz
- Adenosine receptor signalling in Alzheimer's disease
October 2022 "Alzheimer's disease (AD) is the most common dementia in the elderly and its increasing
- Focusing on the role of secretin/adhesion (Class B) G protein-coupled receptors in placental...
October 2022 Focusing on the role of secretin/adhesion (Class B) G protein-coupled receptors in placental
- Membrane Lipids Are an Integral Part of Transmembrane Allosteric Sites in GPCRs: A Case Study of...
October 2022 Membrane Lipids Are an Integral Part of Transmembrane Allosteric Sites in GPCRs: A Case
- Genome-scale CRISPR screening reveals that C3aR signaling is critical for rapid capture of fungi...
October 2022 Genome-scale CRISPR screening reveals that C3aR signaling is critical for rapid capture
- Keratinocyte-derived defensins activate neutrophil-specific receptors Mrgpra2a/b to prevent skin...
October 2022 Keratinocyte-derived defensins activate neutrophil-specific receptors Mrgpra2a/b to prevent
- Structure-Based Discovery of Negative Allosteric Modulators of the Metabotropic Glutamate Receptor 5
October 2022 "Recently determined structures of class C G protein-coupled receptors (GPCRs) revealed