As GTP stabilizes and migrates towards the P loop, it causes the TCAT motif to shift, a key movement This helix undergoes significant restructuring—it breaks and reforms closer to the TCAT motif, which

class A GPCRs and existing experimental data in the literature as constraints, we pinpointed conserved motifs

We further demonstrate using NMR spectroscopy that a polyproline motif within arrestin-3 interacts directly

enriched for highly impactful, recurrent mutations at selected cognate positions of known functional motifs

Structural snapshots uncover a key phosphorylation motif in GPCRs driving β-arrestin activation.

17 out of the 25 spots have been filled! Team Registrations are also available!  Amgen To Present Tezspire® Phase 2A COPD Data At ATS 2024 GPCR Events, Meetings, and Webinars April 17 – May 1, 2024 | FREE ASPET Virtual Award Lecture Series May 13 - 17, 2024 | 20th Annual PEGS Boston 2024 | 9th GPCRs in Medicinal Chemistry October 23 - 25, 2024 | 11th Adhesion GPCR Workshop July 12 - 17

March 2022 "February 17, 2022 08:00 AM Eastern Standard Time SAN FRANCISCO & SHANGHAI- ShouTi Inc.,

Pharm-Tox Summit April 1 - 5, 2025 | XXIII GEM Meeting in 2025 April 3 - 6, 2025 | ASPET 2025 April 14 - 17 May 20 - 22, 2025 | SLAS Europe 2025 June 16 - 19, 2025 | BIO International Convention 2025 July 12 - 17

Montana Molecular is joining the BioTools Innovator program GPCR Events, Meetings, and Webinars May 13 - 17 2024 | 9th GPCRs in Medicinal Chemistry October 23 - 25, 2024 | 11th Adhesion GPCR Workshop July 12 - 17

10 signaling in human macrophage cell types, but they also suppress the pro-inflammatory interleukin-17A + population in TH 17-differentiated CD4+ T cells."

Target October 2024 | Biologics US 2024   October 2 - 4, 2024 | 9th GPCRs in Medicinal Chemistry October 17 GPCR Forum Conference November 26 - 28, 2024 | GPCRs-Targeted Drug Discovery Summit Europe July 12 - 17

December 2021 "Geneva, Switzerland, December 17, 2021 – Addex Therapeutics Ltd (SIX: ADXN and Nasdaq

May 2022 " MONTREAL (CANADA) – May 17, 2022 – Inversago Pharma Inc.

development of new gastrointestinal therapeutics Tokyo, Japan, Cambridge, UK and New York, USA – May 17

Adolescents with Classic CAH - Two Phase 3 Global Registrational Studies Currently Underway in Pediatric (2–17

I-GPCRNet (October 25 - 27, 2023) GPCR Retreat (November 2 - 4, 2023) MPGPCR Conference (November 15 -17

GEM2023 (14-17 March 2023). 8th and final ERNEST Meeting May 3-7, 2023 in Crete.

I-GPCRNet (October 25 - 27, 2023) GPCR Retreat (November 2 - 4, 2023) MPGPCR Conference (November 15 -17

Herein, we demonstrate that a thiophene modification at the C8 position in the common adenine scaffold Structural analysis revealed that the introduced thiophene modification restricted receptor conformational

disorders, today announced it is advancing TRV045 into clinical development, following receipt of a notification

Systematic modification of 1 was performed to produce compounds with improved potency and ADME properties

a process by which post-transcriptional changes of mRNA nucleotides alter protein function through modification

G-protein signaling activates the MAPK Fus3, which phosphorylates the RGS; however, the role of this modification

receptors as key regulators of transcriptional programmes will be introduced as well as epigenetic modifications

September 2022 "The function of the actin cytoskeleton in cellular motility and trafficking has been

teaching purpose, the TeachOpenCADD material can serve as starting point for users’ project-directed modifications

endoplasmic reticulum, GPCRs are transported to the Golgi apparatus to undergo additional post-translational modifications