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276 items found for "Cell cycle"
- 📰 GPCR Weekly News, February 12 to 18, 2024
Endocrinology, and Taste The Role of G Protein-Coupled Receptors and Receptor Kinases in Pancreatic β-Cell
- 📰 GPCR Weekly News, December 11 to 17, 2023
Spectrometry (TIMS-TOF MS) A rapid, tag-free way to purify functional GPCRs tANCHOR fast and cost-effective cell-based
- Targeting Intracellular Allosteric Sites in GPCRs
Exploring the intracellular allosteric site GPCRs represent one of the largest and most vital families of cell
- Artificial intelligence – faster, smarter, cheaper GPCR drug discovery
create large datasets regarding ligand synthesis and screening, ligand binding assays, signaling assays, cell While classical ML models are effective for datasets for which the relevant features are well understood Thomas, Smith, O’Boyle, de Graaf & Bender, 2021) and 4) limit of input data can lead to a phenomenon called
- Structural landscape of the Chemokine Receptor system
great versatility, with more than 50 chemokines interacting with over 20 receptors expressed on various cell CKRs structures complexes, the disulfide bridges formed between the N-loop and the β3-strand align well The active state structure of CCR2 with its endogenous agonist CCL2, as well as inactive states with
- 📰 GPCR Weekly News
hippocampal neurons, selectively reduces CaV 3.2 and CaV 3.3 currents GPCR Binders, Drugs, and more LP2, a cyclic Advisory Board with appointment of immuno-oncology experts More millions roll in for Sosei Heptares Call
- John Streicher talks about his work on terpenes found in cannabis as these may be a novel way to ...
cannabis, but John Streicher , PhD, takes a closer look at the plant’s aromatic chemical compounds called
- GPR110, a receptor for synaptamide, expressed in osteoclasts negatively regulates osteoclastogenesis
GPR110 belongs to adhesion GPCR and was the functional receptor of N-docosahexaenoyl ethanolamine (also called
- The Gluopsins: Opsins without the Retinal Binding Lysine
Thus, we call them gluopsins.
- First in Human: Early-stage COVID therapies hold promise against omicron variant
COVID-19 variants, including the delta and omicron mutations, Vir CEO George Scangos said on a Dec. 7 call
- Novel Therapies for Cardiometabolic Disease: Recent Findings in Studies with Hormone...
One successful strategy is the so-called metabolic surgery whose beneficial effects are beyond dietary
- Intermolecular Interactions in G Protein-Coupled Receptor Allosteric Sites at the Membrane Interface
Interface from Molecular Dynamics Simulations and Quantum Chemical Calculations "Allosteric modulators are called
- A Model for the Signal Initiation Complex Between Arrestin-3 and the Src Family Kinase Fgr
We report that arrestin-3 modulates Fgr activity with a hallmark bell-shaped concentration-dependence
- Chemical signaling regulates axon regeneration via the GPCR-Gqα pathway in Caenorhabditis elegans
C. elegans secretes a family of small-molecule pheromones called ascarosides, which serve various functions
- 📰 GPCR Weekly News
Special report 2022: Meet 20 women blazing trails in biopharma R&D ERNEST - 2022 Scientific Outputs Call
- 📰 GPCR Weekly News - January 9 to 15, 2023
collaborations GPCR Therapeutics Announces Launch of US Phase 2 Trial of GPC-100 in Multiple Myeloma Call
- 📰 GPCR Weekly News, February 6 to 12, 2023
Listing Rule 5635(c)(4) arcoscreen is one of the 13 biotech companies to discover in western in 2023 Call
- Adhesion GPCR Consortium Newsletter - May 2024
The family of adhesion GPCRs called the Latrophilins or ADGRLs first captured my attention due to their
- 📰 GPCR Weekly News, March 18 to 24, 2024
receptors in colitis GPCRs in Oncology and Immunology Polarizing itch Biochemical pharmacology of adenylyl cyclases
- PH-Binding Motif in PAR4 Oncogene: From Molecular Mechanism to Drug Design
Pc(4-4), a lead backbone cyclic peptide, was selected out of a mini-library, directed toward PAR2&4 PH-binding
- Synthesis and characterization of an orally bioavailable small molecule agonist of the apelin recept
Previously, we had identified a novel pyrazole-based agonist 1 ((S)-N-(1-(cyclobutylamino)-1-oxo-5-(piperidin -1-yl)pentan-3-yl)-1-cyclopentyl-5-(2,6-dimethoxyphenyl)-1H-pyrazole-3-carboxamide hydrochloride) of
- Structure of Mycobacterium tuberculosis Cya, an evolutionary ancestor of the mammalian membrane...
Structure of Mycobacterium tuberculosis Cya, an evolutionary ancestor of the mammalian membrane adenylyl cyclases " Mycobacterium tuberculosis adenylyl cyclase (AC) Rv1625c/Cya is an evolutionary ancestor of the mammalian Although the vital role of ACs in cellular signalling is well established, the function of their transmembrane
- ChemoCentryx Announces EU Approval of TAVNEOS® (avacopan) for the Treatment of ANCA-Associated ...
TAVNEOS® (avacopan) has been approved within the European Union in combination with a rituximab or cyclophosphamide TAVNEOS will receive marketing authorization in all member states of the European Union, as well as in
- Positive Recommendation for Use of TAVNEOS™ (avacopan) in ANCA Vasculitis Adopted by European ...
orally administered selective complement 5a receptor inhibitor, in combination with a rituximab or cyclophosphamide