Ecosystem
Beta Site
Search Results
323 items found for "Dopamine receptor D3"
- Applying Pharmacology to Drug Discovery
My interests are in receptor theory, pharmacology applied to drug discovery and allosteric protein function
- Functional Assessment of Cancer-Linked Mutations in Sensitive Regions of Regulators of G Protein Signaling Predicted by Three-Dimensional Missense Tolerance Ratio Analysis
January 1, 2023 Abstract Regulators of G protein signaling (RGS) proteins modulate G protein-coupled receptor Here we analyze the RGS domains of 15 RGS protein family members using a novel bioinformatic tool that
- GPR4 in the pH-dependent migration of melanoma cells in the tumor microenvironment
Membrane-bound receptors, such as the proton-sensitive GPCR (pH-GPCR) GPR4, are considered as potential
- High expression of GPR50 promotes the proliferation, migration and autophagy of hepatocellular carcinoma cells in vitro
of hepatocellular carcinoma cells in vitro Published date June 26, 2023 Abstract "G protein-coupled receptors
- Metallo-protease Peptidase M84 from Bacillusaltitudinis induces ROS-dependent apoptosis in ovarian cancer cells by targeting PAR-1
This established Peptidase M84 as a drug candidate for receptor mediated targeted-therapy of ovarian
- A GPCR-neuropeptide axis dampens hyperactive neutrophils by promoting an alternative-like polarization during bacterial infection
Here, we demonstrated that the neutrophil-expressed G-protein-coupled receptor (GPCR) Mrgpra1 is a negative
- About Us | Dr. GPCR Ecosystem
GPCR Ecosystem We bring the GPCR community to fuel GPCR drug discovery one receptor at a time.
- CB2 stimulation of adipose resident ILC2s orchestrates immune balance and ameliorates type 2 diabetes mellitus
Here, we demonstrate that CB2, a G-protein-coupled receptor (GPCR) and member of the endocannabinoid
- A2aR on lung adenocarcinoma cells: A novel target for cancer therapy via recruiting and regulating tumor-associated macrophages
recruiting and regulating tumor-associated macrophages Published date May 28, 2023 Abstract "Adenosine 2a receptor
- Small-molecule targeting of GPCR-independent noncanonical G-protein signaling in cancer
date April 25, 2023 Abstract " Activation of heterotrimeric G-proteins (Gαβγ) by G-protein-coupled receptors
- Structural Basis for the Recognition of GPRC5D by Talquetamab, a Bispecific Antibody for Multiple Myeloma
G-protein-coupled receptor class C group 5 member D (GPRC5D), an orphan GPCR predominantly expressed
- Principles of Pharmacology in Drug Discovery I
My interests are in receptor theory, pharmacology applied to drug discovery and allosteric protein function
- In Silico Design of Novel RGS2-Galpha-q Interaction Inhibitors with Anticancer Activity
subunits of G-proteins (Gα) by accelerating their GTP hydrolysis rates, which terminates G-protein coupled receptor
- GPCR signaling contributes to immune characteristics of microenvironment and process of EBV-induced lymphomagenesis
Enhanced expression of chemokine receptor-1 (CCR1) on malignant and immunosuppressive cells modulated
- Systems modeling of oncogenic G-protein and GPCR signaling reveals unexpected differences in downstream pathway activation
In the present study, we first develop a mechanistic mathematical model of a G-protein coupled receptor
- NPFF stimulates human ovarian cancer cell invasion by upregulating MMP-9 via ERK1/2 signaling
NPFF regulates a variety of physiological functions by binding to a G protein-coupled receptor (GPCR)
- Neurotoxicity and accumulation of CPPD quinone at environmentally relevant concentrations in Caenorhabditis elegans
Additionally, among examined G protein-coupled receptor (GPCR) genes, exposure to CPPDQ (0.01-10 μg/L
- The GPCR-Gαs-PKA signaling axis promotes T cell dysfunction and cancer immunotherapy failure
G-protein-coupled receptors (GPCRs) are the most intensively studied drug targets but are underexplored
- Regulator of G protein signaling 16 restrains apoptosis in colorectal cancer through disrupting TRAF6-TAB2-TAK1-JNK/p38 MAPK signaling
(RGS) protein family modulators play essential role within regulating downstream signaling of GPCR receptors
- GPR176 promotes fibroblast-to-myofibroblast transition in organ fibrosis progression
Although G protein-coupled receptors (GPCRs) are among the targets of current antifibrotic drugs, no
- Purinergic GPCR-integrin interactions drive pancreatic cancer cell invasion
Moreover, receptor-integrin interactions were required for effective downstream signalling, leading to
- LP2, a cyclic angiotensin-(1-7) analog extended with an N-terminal D-lysine, impairs growth of patient-derived xenografts of colorectal carcinoma in mice
It is a specific agonist of the angiotensin II type 2 receptor.
- Mechanistic exploration of bioactive constituents in Gnetum gnemon for GPCR-related cancer treatment through network pharmacology and molecular docking
network pharmacology and molecular docking Published date October 28, 2024 Abstract "G Protein-Coupled Receptors
- Principles of Pharmacology in Drug Discovery II
Receptor data shows how GPCR control of cellular function goes far beyond simple second messenger production
- CircFKBP5 Suppresses Apoptosis and Inflammation and Promotes Osteogenic Differentiation
pull-down assays were used to confirm the binding between miR-708-5p and circFKBP5 or G-protein-coupled receptor
- TIPE proteins control directed migration of human T cells by directing GPCR and lipid second messenger signaling
G-protein coupled receptors (GPCRs) are essential for sensing chemokine gradients and directing the movement
- RGS5 maintaining vascular homeostasis is altered by the tumor microenvironment
Background: Regulator of G protein signaling 5 (RGS5), as a negative regulator of G protein-coupled receptor
- Opposite Effects of Src Family Kinases on YAP and ERK Activation in Pancreatic Cancer Cells: Implications for Targeted Therapy
Previously, we identified potent positive crosstalk between insulin/IGF-1 receptors and G protein-coupled
