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264 items found for "IJzerman AP"
- Free-Energy Simulations Support a Lipophilic Binding Route for Melatonin Receptors
for 2-iodomelatonin, a nonselective agonist with a slower dissociation rate from the MT2 receptor, applying
- The development of modulators for lysophosphatidic acid receptors: A comprehensive review
While no drugs targeting LPARs have been approved by the FDA thus far, at least three antagonists have
- On-cell nuclear magnetic resonance spectroscopy to probe cell surface interactions
In this review, we outline some key NMR techniques applied for on-cell NMR studies through both solution In particular, we focus on the application of on-cell NMR spectroscopy to characterize ligand interactions We also provide a brief survey of the applicability of on-cell NMR approaches to other classes of cell
- Involvement of various chemokine/chemokine receptor axes in trafficking and oriented locomotion ...
Application of mesenchymal stem cells (MSCs) as an emerging approach was recruited forthe treatment of in the recruitment and oriented trafficking of immune cells both towards and within the CNS and it appears
- Rescue of Cell Surface Expression and Signaling of Mutant Follicle-Stimulating Hormone Receptors
Here we demonstrate that a similar approach can be employed to rescue mutant follicle-stimulating hormone
- GPCRS: AN ODYSSEY FROM STRUCTURE, SIGNALING AND REGULATION TO THERAPEUTICS
APRIL 06 - 09, 2022 | | SNOWBIRD RESORT, UTAH, UNITED STATES The superfamily of G protein-coupled receptors New approaches to GPCR drug discovery.
- Obesity-induced changes in human islet G protein-coupled receptor expression: Implications for ...
The islets of Langerhans are central to appropriate glucose homeostasis through their secretion of insulin
- TeachOpenCADD - A teaching platform for computer-aided drug design
such tools is available, only few freely accessible examples teach underlying concepts focused on CADD applications
- VIB spin-off Confo Therapeutics Enters Collaborative Agreement with Regeneron
December 2021 "30/11/2021 Confo will work together with Regeneron to apply its GPCR drug discovery ConfoBodies® – to stabilize GPCRs (G protein-coupled receptors) in disease-relevant conformations, will be applied
- Trevena Adds Seasoned Biopharma Commercial Executive to Senior Leadership Team
November 2021 "November 11, 2021 7:00am EST Patricia Drake appointed new Chief Commercial Officer CHESTERBROOK
- Newly launched antibody libraries put hard-to-drug targets within reach
As a result, most approved library-derived antibodies originate from just three libraries.
- Functional molecular switches of mammalian G protein-coupled bitter-taste receptors
We designed an integrative approach to improve comparative modeling of TAS2Rs.