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297 items found for "Kinin receptors"
- CB2 stimulation of adipose resident ILC2s orchestrates immune balance and ameliorates type 2 diabetes mellitus
Here, we demonstrate that CB2, a G-protein-coupled receptor (GPCR) and member of the endocannabinoid
- Metallo-protease Peptidase M84 from Bacillusaltitudinis induces ROS-dependent apoptosis in ovarian cancer cells by targeting PAR-1
This established Peptidase M84 as a drug candidate for receptor mediated targeted-therapy of ovarian
- Session VIII * | Adhesion GPCR Workshop 2024 | Dr. GPCR Ecosystem
Characterization of Phenotypes Associated with GPR110 Deletion Hee-Yong Kim Abstract "G-protein coupled receptor GPR110 is also highly expressed in the kidney, however, little is known about the function of this receptor
- Small-molecule targeting of GPCR-independent noncanonical G-protein signaling in cancer
date April 25, 2023 Abstract " Activation of heterotrimeric G-proteins (Gαβγ) by G-protein-coupled receptors
- Inhibition of Relaxin Autocrine Signaling Confers Therapeutic Vulnerability in Ovarian Cancer
that 3BP2 has pleiotrophic function controlling bone homeostasis, immune cell function and scavenger receptor
- A2aR on lung adenocarcinoma cells: A novel target for cancer therapy via recruiting and regulating tumor-associated macrophages
recruiting and regulating tumor-associated macrophages Published date May 28, 2023 Abstract "Adenosine 2a receptor
- Structural Basis for the Recognition of GPRC5D by Talquetamab, a Bispecific Antibody for Multiple Myeloma
G-protein-coupled receptor class C group 5 member D (GPRC5D), an orphan GPCR predominantly expressed
- Unveiling Non-Canonical Functions for Gαq Signaling Pathways
Ribas has also described a new protective role of G protein-coupled receptor kinase 2 (GRK2), a known
- Principles of Pharmacology in Drug Discovery I | Dr. GPCR Ecosystem
My interests are in receptor theory, pharmacology applied to drug discovery and allosteric protein function
- Ep 106 with Dr. Bruno Giros
Laboratory directed by Jean-Charles Schwartz in Paris, where he cloned and characterized dopamine D2 and D3 receptor
- LP2, a cyclic angiotensin-(1-7) analog extended with an N-terminal D-lysine, impairs growth of patient-derived xenografts of colorectal carcinoma in mice
It is a specific agonist of the angiotensin II type 2 receptor.
- GPCR signaling contributes to immune characteristics of microenvironment and process of EBV-induced lymphomagenesis
Enhanced expression of chemokine receptor-1 (CCR1) on malignant and immunosuppressive cells modulated
- In Silico Design of Novel RGS2-Galpha-q Interaction Inhibitors with Anticancer Activity
subunits of G-proteins (Gα) by accelerating their GTP hydrolysis rates, which terminates G-protein coupled receptor
- Regulator of G protein signaling 16 restrains apoptosis in colorectal cancer through disrupting TRAF6-TAB2-TAK1-JNK/p38 MAPK signaling
(RGS) protein family modulators play essential role within regulating downstream signaling of GPCR receptors
- Pancreatic ductal adenocarcinoma, β-blockers and antihistamines: A clinical trial is needed
McCormick, Cristina Salmerón, Paul A Insel Tags antihistamine , cancer , gastrointestinal , histamine receptor
- The GPCR-Gαs-PKA signaling axis promotes T cell dysfunction and cancer immunotherapy failure
G-protein-coupled receptors (GPCRs) are the most intensively studied drug targets but are underexplored
- GPR176 promotes fibroblast-to-myofibroblast transition in organ fibrosis progression
Although G protein-coupled receptors (GPCRs) are among the targets of current antifibrotic drugs, no
- Systems modeling of oncogenic G-protein and GPCR signaling reveals unexpected differences in downstream pathway activation
In the present study, we first develop a mechanistic mathematical model of a G-protein coupled receptor
- Purinergic GPCR-integrin interactions drive pancreatic cancer cell invasion
Moreover, receptor-integrin interactions were required for effective downstream signalling, leading to
- Neurotoxicity and accumulation of CPPD quinone at environmentally relevant concentrations in Caenorhabditis elegans
Additionally, among examined G protein-coupled receptor (GPCR) genes, exposure to CPPDQ (0.01-10 μg/L
- NPFF stimulates human ovarian cancer cell invasion by upregulating MMP-9 via ERK1/2 signaling
NPFF regulates a variety of physiological functions by binding to a G protein-coupled receptor (GPCR)
- Advanced data analysis for GPCR pharmacology | Dr. GPCR Ecosystem
He completed his Ph.D. in biochemistry, studying allosteric modulation of dopamine receptors, from the
- Proteogenomic landscape and clinical characterization of GH-producing pituitary adenomas/somatotroph pituitary neuroendocrine tumors
wild-type and mutant GNAS samples identified by nontargeted proteomics and involved in G protein-coupled receptor
- Mechanistic exploration of bioactive constituents in Gnetum gnemon for GPCR-related cancer treatment through network pharmacology and molecular docking
network pharmacology and molecular docking Published date October 28, 2024 Abstract "G Protein-Coupled Receptors
- RGS5 maintaining vascular homeostasis is altered by the tumor microenvironment
Background: Regulator of G protein signaling 5 (RGS5), as a negative regulator of G protein-coupled receptor
- CircFKBP5 Suppresses Apoptosis and Inflammation and Promotes Osteogenic Differentiation
pull-down assays were used to confirm the binding between miR-708-5p and circFKBP5 or G-protein-coupled receptor
- Exploiting frequent and specific expression of PRL3 in pediatric solid tumors for first-in-child use of PRL3-zumab humanized antibody
tumors in relation to survival outcomes, expression of angiogenesis markers, and G-protein-coupled receptor
- TIPE proteins control directed migration of human T cells by directing GPCR and lipid second messenger signaling
G-protein coupled receptors (GPCRs) are essential for sensing chemokine gradients and directing the movement
