Search Results
279 items found for "Tatiana Da Ros"
- Integration and Spatial Organization of Signaling by G Protein-Coupled Receptor Homo- and ...
we summarize evidence that supports these conjectures, fostering new ideas about the physiological role
- Rhodopsin as a Molecular Target to Mitigate Retinitis Pigmentosa
These disorders are mainly related to the abnormalities in the rod G protein-coupled receptor (GPCR),
- Self-docking and cross-docking simulations of G protein-coupled receptor-ligand complexes
Their abundance and role in nearly all physiological systems make GPCR the largest protein family targeted
- Bursicon receptor gene HLGR2 as a potential RNA interference target for control of the fall ...
Unlike LGR2 in other insect species, HLGR2 was found to play a crucial role in the control of H. cunea
- Targeted Activation of G-Protein Coupled Receptor-Mediated Ca 2+ Signaling Drives Enhanced Cartilage
signaling platforms permitting precise and selective Ca2+ signal transduction can improve dissection of the roles We previously demonstrated hM3Dq's ability to precisely and synthetically initiate robust [Ca2+]i transients and cartilage-like matrix production, and it established hM3Dq as a powerful tool for elucidating the role
- Prostaglandin signaling in ciliogenesis and development
Recent studies have revealed that PGs play pivotal roles in embryo development, ciliogenesis, and organ
- HBx induces hepatocellular carcinogenesis through ARRB1-mediated autophagy to drive the G 1/S cycle
However, the role of ARRB1 in HBx-related HCC remains unclear. Our results demonstrate that ARRB1 plays a critical role in HBV-related HCC via modulating autophagy
- GPCRs Are Optimal Regulators of Complex Biological Systems and Orchestrate the Interface between ...
GPCRs also possess a pivotal role in the regulation of the physiological balance between healthy and
- GPCR voltage dependence controls neuronal plasticity and behavior
G-protein coupled receptors (GPCRs) play a paramount role in diverse brain functions. Together, this study identifies a physiological role for the voltage dependency of GPCRs by demonstrating Thus, this study suggests that GPCR voltage dependency plays a role in many diverse neuronal functions
- A Model for the Signal Initiation Complex Between Arrestin-3 and the Src Family Kinase Fgr
arrestin-3 modulates Fgr activity with a hallmark bell-shaped concentration-dependence, consistent with a role
- Chemogenetic stimulation of the G i pathway in astrocytes suppresses neuroinflammation
Although several GPCRs have been studied in astrocytes using a chemogenetic approach, the functional role In this study, we evaluated the role of the astrocytic Gi pathway in neuroinflammation using a Gi -coupled Taken together, our results indicate that the astrocytic Gi pathway plays an inhibitory role in neuroinflammation
- Biphasic activation of β-arrestin 1 upon interaction with a GPCR revealed by methyl-TROSY NMR
β-arrestins (βarrs) play multifaceted roles in the function of G protein-coupled receptors (GPCRs). βarrs
- Constitutive, Basal, and β-Alanine-Mediated Activation of the Human Mas-Related G Protein-Coupled ..
and in cardiovascular tissue, linking them to pseudo-allergic drug reactions and suggesting a pivotal role Overall, the observation that MRGPRD mediates the release of IL-6 in an in vitro system, hints at a role
- G protein-coupled receptor interactions and modification of signalling involving the ghrelin ...
Known roles of GHSR1a now extend to regulation of neurogenesis, learning and memory, gastrointestinal
- The mouse cytomegalovirus G protein-coupled receptor homolog, M33, coordinates key features of ...
Animal models of CMV provide insights into their role in viral fitness. homologs with phylogenetic evidence for independent gene capture events, signifying important in vivo roles
- In Vitro and In Silico Characterization of Kurarinone as a Dopamine D 1A Receptor Antagonist and ...
provide neuroprotection via inhibition of monoamine oxidases (hMAOs), our study explored the functional role
- Allosteric ligands control the activation of a class C GPCR heterodimer by acting at the transmembra
controlling the activity of GPCR dimers with ligands is a good approach to clarify their physiological roles
- Lysophosphatidic Acid and Several Neurotransmitters Converge on Rho-Kinase 2 Signaling to Manage...
Small-interfering RNA (siRNA) technology was also used to knockdown either ROCK1 or ROCK2. ligands to stimulate ROCK. Microiontophoretically applied H1152, a ROCK inhibitor, and siRNA-induced ROCK2 knockdown both depressed , but not ROCK1, activity and TASK1 inhibition. , and depressed background resting currents via Gαq/ROCK2 signaling.
- Latrophilin-1 drives neuron morphogenesis and shapes chemo- and mechanosensation-dependent ...
. elegans via a trans function Latrophilins are highly conserved Adhesion GPCRs playing essential roles
- β-arrestin1 promotes tauopathy by transducing GPCR signaling, disrupting microtubules and autophagy
G protein-coupled receptors (GPCRs) have been shown to play integral roles in Alzheimer's disease pathogenesis
- G protein-coupled receptors that influence lifespan of human and animal models
Our compilation of data revealed that the mechanisms most involved in the role of GPCRs in lifespan are
- Chemical signaling regulates axon regeneration via the GPCR-Gqα pathway in Caenorhabditis elegans
In this study, we investigated the role of chemical signaling in axon regeneration in Caenorhabditis
- HDX-MS-optimized approach to characterize nanobodies as tools for biochemical and structural ...
pathways in higher eukaryotes is the phosphoinositide 3-kinase (PI3K) pathway, which plays fundamental roles and is dependent on activation by Ras and G protein-coupled receptors (GPCRs) to mediate its cellular roles
- Phenylalanine 193 in Extracellular Loop 2 of the β 2-Adrenergic Receptor Coordinates β-Arrestin ...
and extensively studied GPCR that can provide insight into this aspect of GPCR signaling thanks to robust of extracellular control of intracellular response to stimuli and suggests a previously undescribed role SIGNIFICANCE STATEMENT: The role of extracellular G protein-coupled receptor (GPCR) domains in mediating These results provide new insights on the role of the extracellular domain in differentially modulating
- Involvement of various chemokine/chemokine receptor axes in trafficking and oriented locomotion ...
Chemokine/chemokine receptor axes play a pivotal role in the recruitment and oriented trafficking of
- Orion Announces The Rapid Lead Optimization Of Ob-004 - A Ccr2 Antagonist
The CCL2/CCR2 pathway plays an important role in oncology, inflammatory, metabolic, and neurological
- Deficiency of β-arrestin2 alleviates apoptosis through GRP78-ATF6-CHOP signaling pathway in ...
This research further clarified the underlying role of β-arrestin2 and provided an experimental foundation