Search Results
362 items found for "Vivian G Oehler"
- RAB-Symposium - Regulatory Autoantibodies Targeting GPCRs. September 15-16, 2022. Lübeck, Germany...
gives me great pleasure to announce the fourth hybrid symposium on regulatory autoantibodies targeting G-protein-coupled
- New Resources in GPCRdb
Gáspár Pándy-Szekeres ) will present and demonstrate the newest resources of the GPCRdb: 1) the new G
- Glucagon receptor-mediated regulation of gluconeogenic gene transcription is endocytosis-dependent..
regulation of gluconeogenic gene transcription is endocytosis-dependent in primary hepatocytes "A number of G
- The Adhesion GPCR VLGR1/ADGRV1 Regulates the Ca2+ Homeostasis at Mitochondria-Associated ER Membrane
October 2022 "The very large G protein-coupled receptor (VLGR1, ADGRV1) is the largest member of the
- N-Acyl Amides from Neisseria meningitidis and Their Role in Sphingosine Receptor Signaling
meningitidis and identified 30 N-acyl amides with representative members serving as agonists of the G-protein
- Keratinocyte-derived defensins activate neutrophil-specific receptors Mrgpra2a/b to prevent skin...
Here, we discovered that the epithelial-cell-derived antimicrobial peptides defensins activated orphan G-protein-coupled
- GPCR Agonist-to-Antagonist Conversion: Enabling the Design of Nucleoside Functional Switches for...
Enabling the Design of Nucleoside Functional Switches for the A2A Adenosine Receptor "Modulators of the G
- Rhodopsin as a Molecular Target to Mitigate Retinitis Pigmentosa
These disorders are mainly related to the abnormalities in the rod G protein-coupled receptor (GPCR),
- Deciphering the signaling mechanisms of β-arrestin1 and β-arrestin2 in regulation of cancer cell...
recruitment, activation, and scaffolding of numerous cytoplasmic signaling complexes and assist in G-protein
- β-arrestin1 and 2 exhibit distinct phosphorylation-dependent conformations when coupling to the...
coupling to the same GPCR in living cells "β-arrestins mediate regulatory processes for over 800 different G
- Drug Discovery Picks Up the Pace, Stays on Target
high-throughput drug screening, drug efficacy analyses, and toxicity studies; technologies that stabilize G
- Prostaglandin signaling in ciliogenesis and development
Many G-protein-coupled receptors (GPCRs) including EP4 are localized in cilia for modulating cAMP signaling
- Lipid Modulation of a Class B GPCR: Elucidating the Modulatory Role of PI(4,5)P 2 Lipids
4,5-bisphosphate (PI(4,5)P2) lipids have been shown to stabilize an active conformation of class A G-protein
- Ligands can differentially and temporally modulate GPCR interaction with 14-3-3 isoforms
Besides G-proteins and β-arrestins, 14-3-3 proteins participate in GPCR trafficking and signaling, and
- Computational study of the conformational ensemble of CX3C chemokine receptor 1 (CX3CR1) and its...
antagonist and agonist ligands "The CX3C chemokine receptor 1 (CX3CR1), a member of the class A of G
- Functional modulation of PTH1R activation and signaling by RAMP2
Receptor-activity-modifying proteins (RAMPs) are ubiquitously expressed membrane proteins that associate with different G
- Accelerating GPCR Drug Discovery With Conformation-Stabilizing VHHs
June 2022 "G protein-coupled receptors (GPCRs) represent a major therapeutic target class as they play
- 📰 GPCR Weekly News, June 5 to 11, 2023
Hexahydroquinoline Derivatives are Selective Agonists for the Adhesion G Protein-Coupled Receptor ADGRG1 The G protein-coupled receptor neuropeptide receptor-15 modulates larval development via the transforming
- Deciphering the signaling mechanisms of β-arrestin1 and β-arrestin2 in regulation of cancer cell...
recruitment, activation, and scaffolding of numerous cytoplasmic signaling complexes and assist in G-protein
- Sosei Heptares and Kallyope Enter Collaboration to Identify and Validate Novel Gastrointestinal GPCR
the gut-brain axis, have entered a strategic research collaboration to identify and validate novel G
- 📰 GPCR Weekly News, August 14 to 20, 2023
to 20, 2023 Adhesion GPCRs Amelioration of non-alcoholic fatty liver disease by targeting adhesion G that a glucagon-bound extracellular domain of the glucagon receptor is dynamic Ligand recognition and G
- Newly launched antibody libraries put hard-to-drug targets within reach
To target hard-to-drug targets like G protein-coupled receptors (GPCRs), more libraries, including better
- 📰 GPCR Weekly News, February 13 to 19, 2023
Anionic phospholipids control mechanisms of GPCR-G protein recognition. Reviews, GPCRs, and more Single nucleotide variations encoding missense mutations in G protein-coupled
- GPCR kinase phosphorylation of distal C-tail sites specifies βarrestin1-mediated signaling by...
September 2022 "G protein-coupled receptor (GPCR) kinases (GRKs) and arrestins mediate GPCR desensitization
- The Bile Acid Membrane Receptor TGR5 in Cancer: Friend or Foe?
September 2022 "The G-protein-coupled bile acid receptor, Gpbar1 or TGR5, is characterized as a membrane
- Confo Therapeutics Doses First Subjects In Phase 1 Clinical Trial Of CFTX-1554 For The Treatment ...
Ghent, Belgium – March 10, 2022 – Confo Therapeutics , a leader in the discovery of medicines targeting G-protein
- GB83, an Agonist of PAR2 with a Unique Mechanism of Action Distinct from Trypsin and PAR2-AP
October 2022 "Protease-activated receptor 2 (PAR2) is a G-protein-coupled receptor (GPCR) activated by
- Comparative study of neuropeptide signaling systems in Hemiptera
Here, 33 neuropeptide precursors and 48 putative neuropeptide G protein-coupled receptor (GPCR) genes