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355 items found for "Ya-Tzu Li"
- 🎧Episode 85 of the Dr. GPCR podcast is here!
GPCR Ecosystem membership or listen wherever you get your podcast for free.
- Structure of Mycobacterium tuberculosis Cya, an evolutionary ancestor of the mammalian membrane...
domain and providing the means for direct regulation of catalytic activity in response to extracellular ligands
- CCL25/CCR9 interaction promotes the malignant behavior of salivary adenoid cystic carcinoma via...
CC chemokine receptor 9 (CCR9), an organ-specific chemokine receptor, interacts with its exclusive ligand
- Fentanyl activates ovarian cancer and alleviates chemotherapy-induced toxicity via opioid...
Although increasing evidence has suggested the direct role of fentanyl on cancer, little is known on
- Multifunctional role of GPCR signaling in epithelial tube formation
During Drosophila embryonic salivary gland (SG) invagination, the GPCR ligand Folded gastrulation (Fog Our data support a model wherein Smog regulates distinct myosin pools and actin cytoskeleton in a ligand-dependent
- PI(4,5)P 2-stimulated positive feedback drives the recruitment of Dishevelled to Frizzled in Wnt-β-c
Using purified Fzd proteins reconstituted in lipid nanodiscs, we investigated the factors that promote We found that the affinity of Fzd for Dvl was not affected by Wnt ligands, in contrast to other members of the GPCR superfamily for which the binding of extracellular ligands affects the affinity for downstream Instead, Fzd-Dvl binding was enhanced by increased concentration of the lipid PI(4,5)P2, which is generated by Dvl-associated lipid kinases in response to Wnt and which is required for LRP5/6 phosphorylation.
- Neuropeptide S Encodes Stimulus Salience in the Paraventricular Thalamus
nucleus accumbens shell and structures in the prefrontal cortex and amygdala, which were previously linked
- Delineation of GPR15 receptor-mediated Gα protein signaling profile in recombinant mammalian cell
receptor-mediated Gα protein signalling using a G protein activation assay and second messenger assay conducted on living
- Lack of Oestrogen Receptor Expression in Breast Cancer Cells Does Not Correlate with Kisspeptin...
KISS1R signalling and physiological output in the hormone receptor-negative MDA-MB-231 and BT-20 cell lines MDA-MB-231 cells are metastatic when implanted in mice while BT-20 are not and remain epithelial-like We show that both cell lines express KISS1R mRNA and respond to KP-10 by elevating calcium mobilisation Interestingly, both cell lines displayed different complements of β-arrestin 1 and 2 expression. stimulate migration or pro-metastatic behaviour, as divergent responses were observed in the two TNBC lines
- GRK3 is a poor prognosticator and serves as a therapeutic target in advanced gastric adenocarcinoma
We identified a novel GRK3 inhibitor, LD2, through a chemical-library screen.
- Chemerin Forms: Their Generation and Activity
Chemerin is produced by the liver and secreted into the circulation as a precursor, but it is also expressed
- Microbial Metabolites Orchestrate a Distinct Multi-Tiered Regulatory Network in the Intestinal Epith
Using shRNA knockdown and CRISPR/Cas9 knockout cell lines, as well as mouse models, we confirmed the These findings shed light on a sophisticated signaling network directed by intestinal microbial metabolites that orchestrate P-gp expression and highlight unappreciated connections between multiple pathways linked
- Endothelin-1 Stimulates PAI-1 Protein Expression via Dual Transactivation Pathway Dependent ROCK...
Smad2L "In addition to the carboxy region, Smad2 transcription factor can be phosphorylated in the linker Phosphorylation of Smad2 linker region (Smad2L) promotes the expression of plasminogen activator inhibitor were investigated<br />by western blotting using protein-specific antibodies against phospho-Smad2 linker
- Neurotransmitters: Potential Targets in Glioblastoma
Significantly, many ligands acting on neurotransmitter receptors have shown great potential for inhibiting
- G protein coupling and activation of the metabotropic GABAB heterodimer
However, little is known about the mechanism for GP coupling and activation for class C GPCRs.
- Pharmacological Properties and Function of PxOctβ3 Octopamine Receptor in Plutella xylostella (L.)
Thus, we investigated the regulatory functions of its β-adrenergic-like octopamine receptor (PxOctβ3)
- Platelets in the NETworks interweaving inflammation and thrombosis
In light of the current COVID-19 pandemic, the topic of immunothrombosis has become more relevant than
- GPCR/endocytosis/ERK signaling/S2R is involved in the regulation of the internalization...
We also adopted live cell imaging to monitor the whole intracellular trafficking process of F-Hst1.
- Regulation of rod photoreceptor function by farnesylated G-protein γ-subunits
Electroretinography showed restoration of visual function in all three transgenic Gγ1-deficient lines In all dark-adapted transgenic lines, Gαt1 was targeted to the outer segments, reversing its diffuse However, Gαt1 translocation in Gγ11 transgenic mice occurred at significantly dimmer background light retina-specific Gγ isoforms by the ubiquitous Gγ11 affects the ability of rods to adapt to background light
- Computational study of the conformational ensemble of CX3C chemokine receptor 1 (CX3CR1) and its...
conformational ensemble of CX3C chemokine receptor 1 (CX3CR1) and its interactions with antagonist and agonist ligands receptor 1 (CX3CR1), a member of the class A of G Protein-Coupled Receptors (GPCR) superfamily, and its ligand characterize the conformational ensemble of the receptor in the presence of its antagonist and agonist ligands the receptor conformational changes and described interactions within its key regions and the bounded ligands
- Functional modulation of PTH1R activation and signaling by RAMP2
modulator of PTH1R, shifting PTH1R to a unique preactivated state that permits faster activation in a ligand-specific
- Structural basis for receptor selectivity and inverse agonism in S1P5 receptors
The structure demonstrates a unique ligand-binding mode, involving an allosteric sub-pocket, which clarifies structures in complex with antagonists and agonists, our structure with S1P5-inverse agonist sheds light
- Cell Surface Calcium-Sensing Receptor Heterodimers: Mutant Gene Dosage Affects Ca 2+ Sensing but...
Venus flytrap (VFT) unit that activates G protein-dependent signaling via twin Cysteine-rich domains linked
- GPR84 signaling promotes intestinal mucosal inflammation via enhancing NLRP3 inflammasome activation
that GPR84 expression in leukocytes is remarkably increased under acute inflammatory stimuli such as lipopolysaccharide
- Dimerization of GPCRs: Novel insight into the role of FLNA and SSAs regulating SST2 and SST5...
Here, we used a proximity ligation assay (PLA)–based approach for the in situ visualization and quantification
- To probe the activation mechanism of the Delta opioid receptor by an agonist ADL5859 started from...
While the receptor with the crystal ligand (i.e. antagonist naltrindole) maintained the inactive conformation the conventional molecular switch analysis and a pairwise distance analysis, which provides a short list
- A central alarm system that gates multi-sensory innate threat cues to the amygdala
Yet little is known about whether and how multi-sensory innate threat cues are integrated and conveyed
- Integrative model of the FSH receptor reveals the structural role of the flexible hinge region
Structurally, the extensive extracellular domain, which contains the hormone-binding site and is linked