Search Results
265 items found for "allosteric modulation"
- Chemogenetic stimulation of the G i pathway in astrocytes suppresses neuroinflammation
was expressed in hippocampal astrocytes of a lipopolysaccharide (LPS)-induced neuroinflammation mouse model
- GPCRS: AN ODYSSEY FROM STRUCTURE, SIGNALING AND REGULATION TO THERAPEUTICS
dissect the molecular mechanisms of GPCR function has revealed new paradigms with increasingly complex models
- Structural dynamics of Smoothened (SMO) in ciliary membrane and its interaction with membrane lipids
carried out MARTINI coarse-grained molecular dynamics simulations of SMO in POPC and in ciliary membrane models
- 📰 GPCR Weekly News, October 9 to 15, 2023
the µ-Opioid Receptor Design and Synthesis of Novel GPR139 Agonists with Therapeutic Effects in Mouse Models
- Neuronal Gα subunits required for the control of response to polystyrene nanoparticles in the ...
Caenorhabditis elegans was used as an animal model, and both gene expression and functional analysis
- The mouse cytomegalovirus G protein-coupled receptor homolog, M33, coordinates key features of ...
Animal models of CMV provide insights into their role in viral fitness.
- 📰 GPCR Weekly News, January 16 to 22, 2023
stimulates the Akt-mTOR axis and in vivo muscle protein synthesis in a dexamethasone-induced muscle atrophy model
- 📰 GPCR Weekly News, March 11 to 17, 2024
Disparate Effects on Islet Insulin Secretion and Content in β-cells in a High Fat Diet-induced Mouse Model
- Biased Agonism at the GLP-1 Receptor: A Pathway to Improved Therapeutic Outcomes
For example, in vivo studies in diabetic models have shown that although exendin-P5 induces lower insulin
- 📰 GPCR Weekly News, January 22 to 28, 2024
Margarita Stampelou, Graham Ladds, and Antonios Kolocouris refine AlphaFold models using binding calculations
- 📰 GPCR Weekly News, April 8 to 14, 2024
self-secreted by yeast expressing a G-protein-coupled receptor Reviews, GPCRs, and more The GLP-1R as a model
- Dimerization of GPCRs: Novel insight into the role of FLNA and SSAs regulating SST2 and SST5...
Moreover, whether octreotide or pasireotide may play modulatory effects and whether FLNA may participate
- TeachOpenCADD - A teaching platform for computer-aided drug design
programming packages for cheminformatics and structural bioinformatics are powerful tools to build modular