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270 items found for "drug discovery"
- Chemogenetic stimulation of the G i pathway in astrocytes suppresses neuroinflammation
(GPCRs) are commonly used in chemogenetics as designer receptors exclusively activated by designer drugs
- Unlocking Cell's Secrets: Spontaneous β-Arrestin-Membrane Preassociation Drives Receptor-Activation
Read the complete article here: https://www.ecosystem.drgpcr.com/gpcr-binders-drugs-and-more/in-depth-molecular-profiling-of-an-intronic-gnao1 -mutant-as-the-basis-for-personalized-high-throughput-drug-screening References Grimes, J., Koszegi,
- Ode to GPCRs
awarded to Carl Ferdinand Cori, Gerty Theresa Cori (née Radnitz), and Bernardo Alberto Houssay for their discoveries decreases the amount of glycogen in the liver and muscles. [1-6] Houssay received this honor for his discoveries was awarded jointly to Ragnar Arthur Granit, Haldan Keffer Hartline, and George David Wald for their discoveries Medicine went to George Herbert Hitchings, Sir James Whyte Black, and Gertrude Belle Elion for their discoveries of important principles for drug treatment.[24–30] Black was particularly interested in developing drugs
- Phenylalanine 193 in Extracellular Loop 2 of the β 2-Adrenergic Receptor Coordinates β-Arrestin ...
These receptors are the most clinically productive drug targets at present.
- Deficiency of β-arrestin2 alleviates apoptosis through GRP78-ATF6-CHOP signaling pathway in ...
syndrome The etiology of primary Sjögren's syndrome (pSS) remains unknown, and there is no ideal drug
- 📰 GPCR Weekly News, May 15 to 21, 2023
Progressive Technologies and Approaches Revealing Novel GPCR Biology and Drug Development Potential.
- Unveiling GPCR Priming: The Hidden Synergy in Cellular Signalling
This has significant implications for drug development, as targeting these non-cognate interactions could
- Nanobodies: New Dimensions in GPCR Signaling Research
lightly represent the potential applications of Nbs to facilitate the development of more selective drugs
- Overview of adhesion GPCRs self-activation
Indeed, despite their broad physiological importance in normal and pathological processes, so far no drugs
- Tectonic Therapeutic Strengthens Leadership Team
Time BOSTON-- Tectonic Therapeutic , Inc. a pre-clinical stage biotechnology company transforming the discovery
- Structural view of G protein-coupled receptor signaling in the retinal rod outer segment
We summarize recent discoveries that have advanced our understanding of rod outer segment (ROS) morphology
- Dr. Rosie Dawaliby Podcast!
🥁 Drum rolls, please! Our guest is the wonderful Dr. Rosie Dawaliby!
- Crinetics Pharmaceuticals Expands Executive Team With Appointment Of James Hassard As Chief ...
(Nasdaq: CRNX), a clinical stage pharmaceutical company focused on the discovery, development, and commercialization
- Crinetics Pharmaceuticals Announces Pricing Of Underwritten Common Stock Offering
(Nasdaq: CRNX), a clinical-stage pharmaceutical company focused on the discovery, development and commercialization
- Precise druggability of the PTH type 1 receptor
sites and identify allosteric modulators of PTHR signaling that could be extended to GPCRs to expedite discoveries
- Dynamic recognition of naloxone, morphine and endomorphin1 in the same pocket of µ-opioid receptors
reveals a dynamic mechanism for the response of MOR to different ligands and provides a basis for the discovery
- Twist Bioscience Launches Revelar Biotherapeutics to Develop and Commercialize Novel COVID-19...
In addition, Revelar will have the ability to leverage the antibody discovery and optimization platform
- Adhesion GPCR Consortium Newsletter - May 2024
For my postdoctoral training, I joined one of the labs that participated in Latrophilins’ discovery,