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329 items found for "receptor binding"
- Ep 141 with Dr Tobi Langenhan
of Dr Andreas Russ at the Department of Biochemistry and first came across GPCRs, particularly the receptor
- Ep 56 with Dr. Adriano Marchese
his postdoctoral training in Jeff Benovic’s laboratory studying the regulation of G protein-coupled receptor
- Retreat | Dr. GPCR Ecosystem
membership will grant you access to a wealth of resources, research, and discussions on your favorite receptor Click the button to unlock premium content, and insights and join our vibrant community of like-minded
- GPR4 in the pH-dependent migration of melanoma cells in the tumor microenvironment
Membrane-bound receptors, such as the proton-sensitive GPCR (pH-GPCR) GPR4, are considered as potential GPCR Industry News Adhesion GPCRs GPCR Events, Meetings, and Webinars Reviews, GPCRs, and more GPCR Binders
- High expression of GPR50 promotes the proliferation, migration and autophagy of hepatocellular carcinoma cells in vitro
of hepatocellular carcinoma cells in vitro Published date June 26, 2023 Abstract "G protein-coupled receptors GPCR Industry News Adhesion GPCRs GPCR Events, Meetings, and Webinars Reviews, GPCRs, and more GPCR Binders
- Metallo-protease Peptidase M84 from Bacillusaltitudinis induces ROS-dependent apoptosis in ovarian cancer cells by targeting PAR-1
Collectively, our findings suggested that Peptidase M84 triggered PAR-1-mediated oxidative stress to This established Peptidase M84 as a drug candidate for receptor mediated targeted-therapy of ovarian GPCR Industry News Adhesion GPCRs GPCR Events, Meetings, and Webinars Reviews, GPCRs, and more GPCR Binders
- A GPCR-neuropeptide axis dampens hyperactive neutrophils by promoting an alternative-like polarization during bacterial infection
Here, we demonstrated that the neutrophil-expressed G-protein-coupled receptor (GPCR) Mrgpra1 is a negative As a subset of neutrophils at steady state expressed NPFF, these findings could have broad implications GPCR Industry News Adhesion GPCRs GPCR Events, Meetings, and Webinars Reviews, GPCRs, and more GPCR Binders
- CB2 stimulation of adipose resident ILC2s orchestrates immune balance and ameliorates type 2 diabetes mellitus
Here, we demonstrate that CB2, a G-protein-coupled receptor (GPCR) and member of the endocannabinoid GPCR Industry News Adhesion GPCRs GPCR Events, Meetings, and Webinars Reviews, GPCRs, and more GPCR Binders
- A journey from Duke to McGill along the dopamine circuit
Laboratory directed by Jean-Charles Schwartz in Paris, where he cloned and characterized dopamine D2 and D3 receptor
- Ep 89 with Dr. Patrick Sexton
, a corresponding member of the International Union of Basic and Clinical Pharmacology Committee on Receptor
- A2aR on lung adenocarcinoma cells: A novel target for cancer therapy via recruiting and regulating tumor-associated macrophages
recruiting and regulating tumor-associated macrophages Published date May 28, 2023 Abstract "Adenosine 2a receptor Constructing models of TAMs and LUAD mice, we find that A2aR highly expressed on LUAD cells promotes GPCR Industry News Adhesion GPCRs GPCR Events, Meetings, and Webinars Reviews, GPCRs, and more GPCR Binders
- Structural Basis for the Recognition of GPRC5D by Talquetamab, a Bispecific Antibody for Multiple Myeloma
G-protein-coupled receptor class C group 5 member D (GPRC5D), an orphan GPCR predominantly expressed GPCR Industry News Adhesion GPCRs GPCR Events, Meetings, and Webinars Reviews, GPCRs, and more GPCR Binders
- Ep 48 with Dr Nyla Naim Dr Michael Lemieux Dr Jason Nasse from Addgene
his Ph.D. in Neuroscience from Ohio State University focusing on synaptic plasticity and adrenergic receptor
- Targeting adenosine signaling for immuno-oncology
Friday, November 3rd / 4:35 PM Abstract "Adenosine (ADO) signaling through A2A and A2B G protein-coupled receptors
- GPCR signaling contributes to immune characteristics of microenvironment and process of EBV-induced lymphomagenesis
Enhanced expression of chemokine receptor-1 (CCR1) on malignant and immunosuppressive cells modulated GPCR Industry News Adhesion GPCRs GPCR Events, Meetings, and Webinars Reviews, GPCRs, and more GPCR Binders
- Systems modeling of oncogenic G-protein and GPCR signaling reveals unexpected differences in downstream pathway activation
In the present study, we first develop a mechanistic mathematical model of a G-protein coupled receptor GPCR Industry News Adhesion GPCRs GPCR Events, Meetings, and Webinars Reviews, GPCRs, and more GPCR Binders
- The GPCR-Gαs-PKA signaling axis promotes T cell dysfunction and cancer immunotherapy failure
G-protein-coupled receptors (GPCRs) are the most intensively studied drug targets but are underexplored GPCR Industry News Adhesion GPCRs GPCR Events, Meetings, and Webinars Reviews, GPCRs, and more GPCR Binders
- Regulator of G protein signaling 16 restrains apoptosis in colorectal cancer through disrupting TRAF6-TAB2-TAK1-JNK/p38 MAPK signaling
(RGS) protein family modulators play essential role within regulating downstream signaling of GPCR receptors GPCR Industry News Adhesion GPCRs GPCR Events, Meetings, and Webinars Reviews, GPCRs, and more GPCR Binders
- GPR176 promotes fibroblast-to-myofibroblast transition in organ fibrosis progression
Although G protein-coupled receptors (GPCRs) are among the targets of current antifibrotic drugs, no GPCR Industry News Adhesion GPCRs GPCR Events, Meetings, and Webinars Reviews, GPCRs, and more GPCR Binders
- Purinergic GPCR-integrin interactions drive pancreatic cancer cell invasion
Moreover, receptor-integrin interactions were required for effective downstream signalling, leading to GPCR Industry News Adhesion GPCRs GPCR Events, Meetings, and Webinars Reviews, GPCRs, and more GPCR Binders
- LP2, a cyclic angiotensin-(1-7) analog extended with an N-terminal D-lysine, impairs growth of patient-derived xenografts of colorectal carcinoma in mice
It is a specific agonist of the angiotensin II type 2 receptor. GPCR Industry News Adhesion GPCRs GPCR Events, Meetings, and Webinars Reviews, GPCRs, and more GPCR Binders
- About Us | Dr. GPCR Ecosystem
GPCR Ecosystem We bring the GPCR community to fuel GPCR drug discovery one receptor at a time. GPCR Ecosystem, you’ll get to: Interact with the members and partners to help you find: Answers to any Find out more about some of our leaders and volunteers below.
- TIPE proteins control directed migration of human T cells by directing GPCR and lipid second messenger signaling
G-protein coupled receptors (GPCRs) are essential for sensing chemokine gradients and directing the movement These findings have implications for therapeutically targeting TIPE proteins in human inflammatory and GPCR Industry News Adhesion GPCRs GPCR Events, Meetings, and Webinars Reviews, GPCRs, and more GPCR Binders
- RGS5 maintaining vascular homeostasis is altered by the tumor microenvironment
Background: Regulator of G protein signaling 5 (RGS5), as a negative regulator of G protein-coupled receptor Conclusions: These findings suggest that tumor microenvironment shifts the function of RGS5 from anti-inflammation GPCR Industry News Adhesion GPCRs GPCR Events, Meetings, and Webinars Reviews, GPCRs, and more GPCR Binders
- Opposite Effects of Src Family Kinases on YAP and ERK Activation in Pancreatic Cancer Cells: Implications for Targeted Therapy
Previously, we identified potent positive crosstalk between insulin/IGF-1 receptors and G protein-coupled GPCR Industry News Adhesion GPCRs GPCR Events, Meetings, and Webinars Reviews, GPCRs, and more GPCR Binders
- Exploiting frequent and specific expression of PRL3 in pediatric solid tumors for first-in-child use of PRL3-zumab humanized antibody
tumors in relation to survival outcomes, expression of angiogenesis markers, and G-protein-coupled receptor These findings support wider exploration of PRL3 expression in embryonal and mesenchymal tumors and further GPCR Industry News Adhesion GPCRs GPCR Events, Meetings, and Webinars Reviews, GPCRs, and more GPCR Binders
- Proteogenomic landscape and clinical characterization of GH-producing pituitary adenomas/somatotroph pituitary neuroendocrine tumors
wild-type and mutant GNAS samples identified by nontargeted proteomics and involved in G protein-coupled receptor GPCR Industry News Adhesion GPCRs GPCR Events, Meetings, and Webinars Reviews, GPCRs, and more GPCR Binders
- Inhibition of Relaxin Autocrine Signaling Confers Therapeutic Vulnerability in Ovarian Cancer
that 3BP2 has pleiotrophic function controlling bone homeostasis, immune cell function and scavenger receptor