GPCR Podcast, we have none other than Dr. Marta Filizola! https://www.ecosystem.drgpcr.com/dr-gpcr-podcast/ #gpcr #drgpcr #podcast

Several neurotransmitters and neuromodulators, acting through G-protein-coupled receptors (GPCRs), fine-tune However, intracellular partners linking GPCRs to TASK1 modulation are not yet well-known. by the physiological neuromodulator lysophosphatidic acid (LPA) through a mechanism entailing Gαi/o-protein These outcomes suggest that LPA and several neurotransmitters impact MN IME via Gαi/o/Gαq-protein-coupled receptors, downstream ROCK2 activation, and subsequent inhibition of TASK1 channels.

September 2022 "Introduction Protease activated receptors 1 (PAR1) and 4 (PAR4) agonists are used to C1-inhibitor (C1INH) is a protease inhibitor present in plasma but not in isolated platelet suspensions Read more at the source #DrGPCR #GPCR #IndustryNews

September 2022 Lack of Oestrogen Receptor Expression in Breast Cancer Cells Does Not Correlate with Kisspeptin Signalling and Migration "Kisspeptin is an anti-metastatic mediator in many cancer types, acting through its receptor been associated with increased invasion and MMP-9 expression, leading to the suggestion that hormone receptor veracity of this claim, we compared endogenous KISS1R signalling and physiological output in the hormone receptor-negative Read more at the source #DrGPCR #GPCR #IndustryNews

Stuart Maudsley on how an aging physiological context affects #GPCR signaling #drgpcr. Register here (FREE) https://www.ecosystem.drgpcr.com/dr-gpcr-virtual-cafe/ #gpcr #drgpcr #virtualcafe

2022 Fly casting with ligand sliding and orientational selection supporting complex formation of a GPCR and a middle sized flexible molecule "A GA-guided multidimensional virtual-system coupled molecular protein, human endothelin receptor type B (hETB). Last, in the pocket, ligand–receptor attractive native contacts are formed. Read more at the source #DrGPCR #GPCR #IndustryNews

GPCR activation, signaling, and intracellular trafficking. Somatostatin receptors (SSTs) are class A GPCRs abundantly expressed in pituitary tumors where they represent The cytoskeletal protein filamin A (FLNA) directly interacts with both somatostatin receptor type 2 ( robust receptor internalization at shorter times than in A7 cells. Read more at the source #DrGPCR #GPCR #IndustryNews

2022 N-terminal alterations turn the gut hormone GLP-2 into an antagonist with gradual loss of GLP-2 receptor selectivity towards more GLP-1 receptor interaction "Background and purpose: To fully elucidate the regulatory role of the GLP-2 system in the gut and the bones, potent and selective GLP-2 receptor (GLP To examine selectivity, COS-7 cells expressing human GLP-1 or GIP receptors were assessed for cAMP accumulation Read more at the source #DrGPCR #GPCR #IndustryNews

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CXV: The Class F of G Protein-Coupled Receptors Yusman Manchanda, Dr. Targeting G protein-coupled receptors for heart failure treatment RAMP and MRAP accessory proteins have variations encoding missense mutations in G protein-coupled receptors may contribute to autism GPCRs to G protein-coupled receptors Unravelling G protein-coupled receptor signalling networks using global CXV: The Class F of G Protein-Coupled Receptors Structural and Molecular Insights into GPCR Function

GPCR podcast is now available! Our guest is Dr. Ben Myers! studying sensory #ionchannels to the group leader at the University of Utah investigating Class F #GPCRs Listen nowhere you get your podcasts https://www.ecosystem.drgpcr.com/dr-gpcr-podcast/ #gpcr #drgpcr

GPCR Podcast is back this week with a brand new episode. Our guest is none other than Dr. Juan Jose Fung, Principal Scientist, at GPCR Therapeutics. https://buff.ly/32fzGbO #gpcr #drgpcr #podcast

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GPCRs in Neuroscience Photopharmacological manipulation of amygdala metabotropic glutamate receptor mGlu4 GPCRs in Oncology and Immunology Pan-cancer functional analysis of somatic mutations in G protein-coupled receptors. Membrane-Protein Study: Importance of Detergent Rigidity-Flexibility Balance in Protein Stability. iORbase Deadline February 12, 2023 Current Technologies To Understand G-Protein-Coupled Receptor Molecular Pharmacology

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Gβγ signaling: mechanisms, functions, and therapeutic targets Constitutive activity of the dopamine receptor Protein-Coupled Receptor Reviews, GPCRs, and more Life, death and resurrection of plant GPCRs Structural 1A Receptor Microenvironment Industry News Addex and Indivior Extend Research Term Of Substance Use Current Technologies To Understand G-Protein-Coupled Receptor Molecular Pharmacology. GPCR Ecosystem

 for their review G Protein-Coupled Receptors: A Century of Research and Discovery Dr. protein-coupled receptors related to autoimmunity in postural orthostatic tachycardia syndrome The binding Signaling Conformation- and activation-based BRET sensors differentially report on GPCR-G protein coupling Reviews, GPCRs, and more Proteome-wide analysis reveals G protein-coupled receptor-like proteins in rice (Oryza sativa) G Protein-Coupled Receptors: A Century of Research and Discovery Challenges and opportunities

A role for BET proteins in regulating basal, dopamine-induced and cAMP/PKA-dependent transcription in neurons The activity of striatal medium-spiny projection neurons is regulated by D1 and D2 dopamine receptors The D1 receptor (D1R) is a Gαs/olf-coupled GPCR which activates a cAMP/PKA/DARPP-32 signalling cascade One candidate effector of PKA-dependent transcriptional regulation is the BET protein Brd4. Finally, we report that JQ1 treatment downregulated expression of many GPCRs and also impaired ERK1/2

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András Tóth, László Hunyady, et al. for their work on G protein-coupled receptor endocytosis generates Adhesion G Protein-Coupled Receptor B1 (ADGRB1/BAI1) Generated from an Alternative Promoter in Intron SUCNR1 G protein-coupled receptor endocytosis generates spatiotemporal bias in β-arrestin signaling protein-coupled receptors Effects of an external static EF on the conformational transition of 5-HT1A and distinctive Gq protein coupling by the kisspeptin receptor Industry News Nxera Pharma Receives US

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GPCR podcast! Give it a listen to hear from Dr. Thomas P. Sakmar on how the molecular studies of rhodopsin paved the way to understanding #GPCRs Be sure to subscribe https://www.ecosystem.drgpcr.com/dr-gpcr-podcast/ #drgpcr #gpcr #podcast

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August 2022 A NanoBRET-Based H 3 R Conformational Biosensor to Study Real-Time H 3 Receptor Pharmacology in Cell Membranes and Living Cells "Conformational biosensors to monitor the activation state of G protein-coupled receptors are a useful addition to the molecular pharmacology assay toolbox to characterize ligand efficacy at the level of receptor proteins instead of downstream signaling. Read more at the source #DrGPCR #GPCR #IndustryNews

regulation of cancer cell cycle and metastasis "β-Arrestins are ubiquitously expressed intracellular proteins activation, followed by receptor endocytosis and ubiquitylation. However, current investigations have now recognized that in addition to GPCR arresting (hence the name of numerous cytoplasmic signaling complexes and assist in G-protein receptor signaling, thus bringing Read more at the source #DrGPCR #GPCR #IndustryNews

Joe Clayton from BioTek Instruments talk about automated micro-plate-based methods for quantifying #GPCR activation. https://www.ecosystem.drgpcr.com/dr-gpcr-virtual-cafe/ #drgpcr #gpcr #virtualcafe

Adhesion GPCRs Adhesion G Protein-Coupled Receptor Gpr126 (Adgrg6) Expression Profiling in Diseased Mouse , Rat, and Human Kidneys GPCR Activation and Signaling Differential regulation of G protein-coupled receptor-associated of Putative Bivalent Dicovalent Ligands for the Adenosine A1 Receptor GPCRs in Cardiology, Endocrinology Protein-Coupled Receptors TOR signaling regulates GPCR levels on the plasma membrane and suppresses the G-Protein Mediated Signaling Networks June 25 - 29, 2024 | FENS Forum 2024 October 2024 | Biologics