Search Results
376 items found for "Helen Su"
- Phosphorylation of RGS regulates MAP kinase localization and promotes completion of cytokinesis
Surprisingly, phosphorylation of the RGS promotes completion of cytokinesis before pheromone-induced
- High GPER expression in triple-negative breast cancer is linked to pro-metastatic pathways and...
our transcriptomic analysis, expression of GPER was correlated with clinicopathological variables and survival value, 26.4% (95/360) of patients showed high GPER expression and significant correlation with the mRNA subtype In quantitative comparison, GPER abundance is correlated with the high-risk subtype of TNBC. Besides, high GPER expression was significantly linked to the worse survival in patients with lymph node These results may supply new insights into GPER-mediated estrogen carcinogenesis in TNBC, thus providing
- A central alarm system that gates multi-sensory innate threat cues to the amygdala
September 2022 "Perception of threats is essential for survival. Previous findings suggest that parallel pathways independently relay innate threat signals from different Here, we report that neurons expressing calcitonin gene-related peptide (CGRP) in the parvocellular subparafascicular
- Integrative model of the FSH receptor reveals the structural role of the flexible hinge region
"The follicle-stimulating hormone receptor (FSHR) belongs to the glycoprotein hormone receptors, a subfamily
- Exploiting Dependence of Castration-Resistant Prostate Cancer on the Arginine Vasopressin ...
proliferation through cAMP/protein kinase A signaling, consistent with AVPR2 coupling to the G protein subunit arginine vasopressin receptors, and knockout of AVP in CRPC cells significantly reduced proliferation suggesting
- Interacting binding insights and conformational consequences of the differential activity of...
Namely, CBD has been suggested to directly trigger receptor’s activation, stabilize CB1 inactive conformations In addition, our results suggest a previously unknown sodium-binding site located in the extracellular
- GASP1 enhances malignant phenotypes of breast cancer cells and decreases their response to...
Functional studies showed that GASP1 knockout significantly suppressed malignant properties of breast and decreases their cellular response to paclitaxel by interacting with and stabilizing IGF1R, and suggests
- A2B Adenosine Receptor Enhances Chemoresistance of Glioblastoma Stem-Like Cells under Hypoxia: New..
aggressive primary brain tumor, characterized by its high chemoresistance and the presence of a cell subpopulation , which extrude drugs outside the cell, such as the multidrug resistance-associated proteins (MRPs) subfamily These data suggest that hypoxia-dependent activation of A2B adenosine receptor promotes survival of GSCs
- β2-Adrenergic Receptor Expression and Intracellular Signaling in B Cells Are Highly Dynamic during..
The change of β2-ADR expression and signaling during sustained inflammation might be an integral part
- Roles of Focal Adhesion Kinase PTK2 and Integrin αIIbβ3 Signaling in Collagen- and GPVI-Dependent...
show that the combination of pGRP with PTK2 inhibition or of pGRP with pCIB > pCIBm in additive ways suppressed The suppressive rather than activating effects of pGRP were confined to blood flow at a high shear rate This work thereby supports the role of PTK2 in integrin αIIbβ3 activation and signaling."
- Biased GPCR signaling by the native parathyroid hormone-related protein 1 to 141 relative to its...
β-arrestin recruitment mediated by ligand-PTHR interactions at the plasma membrane, PTHrP1-141 triggers sustained caused by the stabilization of a singular PTHR conformation and PTHrP1-141 sensitivity to heparin, a sulfated
- PAR-Induced Harnessing of EZH2 to β-Catenin: Implications for Colorectal Cancer
This methylation on a lysine residue at the N-terminal portion of β-catenin suppresses the ubiquitination Our study demonstrates the importance of β-catenin lysine methylation in terms of its sustained expression
- Serotonin Receptor 5-HT2A Regulates TrkB Receptor Function in Heteroreceptor Complexes
Our data reveal the functional role of 5-HT2A–TrkB receptor heterodimerization and suggest that the regulated
- Sweet taste receptor agonists attenuate macrophage IL‐1β expression and eosinophilic inflammation...
myeloid cells plays a causal role in eosinophilic CRS (ECRS) via macrophage IL‐1β overproduction, thereby suggesting Trehalose is a disaccharide sugar with known pro‐autophagy activity and effective in alleviating diverse sought to investigate the therapeutic potential of autophagy‐enhancing agent, trehalose, or related sugar
- Opposite Effects of Src Family Kinases on YAP and ERK Activation in Pancreatic Cancer Cells...
epitogue-tagged YAP mutants in PANC-1 and MiaPaCa-2 cancer cells, models of the aggressive squamous subtype Surprisingly, our results also demonstrate that exposure to SFK inhibitors, including dasatinib or knockdown dasatinib and trametinib potently and synergistically inhibited colony formation by PDAC cells and suppessed
- CD28 and chemokine receptors: Signalling amplifiers at the immunological synapse
functions requiring high sensibility and specificity, T cells need to integrate different stimuli from the surrounding
- GPCR kinase phosphorylation of distal C-tail sites specifies βarrestin1-mediated signaling by...
However, although necessary for some GPCRs, we found that distal C-tail sites might not be sufficient
- GPR108 is required for gambogic acid inhibiting NF-κB signaling in cancer
Depletion of GPR108 dramatically inhibited the survival of various cancers. Overall, our findings supported GPR108 as a promising therapeutic target of cancer, and provided a small
- The Impact of CB1 Receptor on Nuclear Receptors in Skeletal Muscle Cells
One suggested theory is that cannabinoids regulate a variety of physiological processes within the cells demonstrated that 10 nM of ACEA notably amplified mRNA gene expression of NR4A1 and NR4A3; this effect was suppressed
- Induced Human Regulatory T Cells Express the Glucagon-like Peptide-1 Receptor
Recent studies in experimental animals have shown that certain subsets of T cells express functional
- Targeting mGluR2/3 for treatment of neurodegenerative and neuropsychiatric diseases
We then highlight the evidence supporting the use of various drugs including orthosteric and allosteric
- The Bile Acid Membrane Receptor TGR5 in Cancer: Friend or Foe?
member A (RhoA), exchange protein activated by cAMP (Epac), and transient receptor potential ankyrin subtype In this review, we discuss both the ‘friend’ and ‘foe’ features of TGR5 by summarizing its tumor-suppressing
- Isoform-and ligand-specific modulation of adhesion GPCR ADGRL3/Latrophilin3 by a synthetic binder
September 2022 "Adhesion G protein-coupled receptors (aGPCRs) are cell-surface proteins with large extracellular
- Divergent roles for the gut intraepithelial lymphocyte GLP-1R in control of metabolism, microbiota..
Such effects are mediated by the suppression of gut IEL effector functions linked to the dampening of
- Dynamics of tumor-associated macrophages in a quantitative systems pharmacology model of...
As tumor-associated macrophages (TAMs) serve as major contributors to the immuno-suppressive tumor microenvironment
- Trainees, this is for you...
GPCR Summit 2022. Mark your calendar for October 10th and 16th. Become a site member for FREE and submit your abstract today!
- Join Us Now!
GPCR Summit 2022. This is a great opportunity for us to come together and talk GPCRs. Our Summit is FREE for all Ecosystem site members, which is also free! Join us now ➡️ https://www.ecosystem.drgpcr.com/dr-gpcr-summit-2022 #gpcr #drgpcr
- Exscientia and Sanofi Establish Strategic Research Collaboration to Develop AI-driven Pipeline ...
Precision-Engineered Medicines "Collaborative efforts aim to accelerate drug discovery and improve clinical success