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584 items found for "Orphan GPCR"
- Endosomal parathyroid hormone receptor signaling
October 2022 "The canonical model for G protein-coupled receptors (GPCRs) activation assumes that stimulation In this model, GPCR signaling is turned-off by receptor phosphorylation via GPCR kinases (GRKs) and subsequent However, over the last decade, this model has been extended by discovering that some internalized GPCRs Accumulative evidence shows that the location of signaling has an impact on the physiological effects of GPCR Read more at the source #DrGPCR #GPCR #IndustryNews
- Targeting CXCR1 and CXCR2 receptors in cardiovascular diseases
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- Structural perspectives on the mechanism of signal activation, ligand selectivity and allosteric...
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- Endogenous ligand recognition and structural transition of a human PTH receptor
light on the distinct durations of signaling induced by PTH and PTHrP" Read more at the source #DrGPCR #GPCR
- Intermolecular Interactions in G Protein-Coupled Receptor Allosteric Sites at the Membrane Interface
Calculations "Allosteric modulators are called promising candidates in G protein-coupled receptor (GPCR Read more at the source #DrGPCR #GPCR #IndustryNews
- Adenosine receptor signalling in Alzheimer's disease
Emerging evidence suggests adenosine G protein-coupled receptors (GPCRs) are promising therapeutic targets Read more at the source #DrGPCR #GPCR #IndustryNews
- Activation of GPR183 by 7 α,25-Dihydroxycholesterol Induces Behavioral Hypersensitivity through...
Protein Kinase and Nuclear Factor- κ B "Emerging evidence implicates the G-protein coupled receptor (GPCR Read more at the source #DrGPCR #GPCR #IndustryNews
- N-Acyl Amides from Neisseria meningitidis and Their Role in Sphingosine Receptor Signaling
30 N-acyl amides with representative members serving as agonists of the G-protein coupled receptor (GPCR Read more at the source #DrGPCR #GPCR #IndustryNews
- Viral G Protein-Coupled Receptors Encoded by β- and γ-Herpesviruses
acquired genes are transmembrane proteins and cytokines, such as viral G protein-coupled receptors (vGPCRs This review focuses on the vGPCRs encoded by the human β- and γ-herpesviruses. These include receptors from human cytomegalovirus, which encodes four vGPCRs: US27, US28, UL33, and We discuss ligand binding, signaling, and structures of the vGPCRs in light of robust differences from Read more at the source #DrGPCR #GPCR #IndustryNews
- Differences across sexes on head-twitch behavior and 5-HT2A receptor signaling in C57BL/6J mice
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- GB83, an Agonist of PAR2 with a Unique Mechanism of Action Distinct from Trypsin and PAR2-AP
October 2022 "Protease-activated receptor 2 (PAR2) is a G-protein-coupled receptor (GPCR) activated by Read more at the source #DrGPCR #GPCR #IndustryNews
- Structure-Based Discovery of Negative Allosteric Modulators of the Metabotropic Glutamate Receptor 5
October 2022 "Recently determined structures of class C G protein-coupled receptors (GPCRs) revealed treatment of psychiatric and neurodegenerative diseases, and several allosteric modulators of this GPCR libraries have complementary advantages and illustrate how access to high-resolution structures of GPCRs Read more at the source #DrGPCR #GPCR #IndustryNews
- Comparative studies of AlphaFold, RoseTTAFold and Modeller: a case study involving the use of...
G-protein-coupled receptor (GPCR) proteins are particularly interesting since they are involved in numerous work directly compares the performance of these novel deep learning-based protein modeling methods for GPCRs We collected the experimentally determined structures of 73 GPCRs from the Protein Data Bank. Read more at the source #DrGPCR #GPCR #IndustryNews
- Mechanism of enhanced sensitivity of mutated β-adrenergic-like octopamine receptor to amitraz in...
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- Enhanced membrane binding of oncogenic G protein αqQ209L confers resistance to inhibitor YM-254890
October 2022 "Heterotrimeric G proteins couple activated G protein-coupled receptors (GPCR) to intracellular They can also function independently of GPCR activation upon acquiring mutations that prevent GTPase YM-254890 (YM) can inhibit signaling by both GPCR-activated wild type αq and GPCR-independent αqQ209L GPCR-dependent signaling by PM-restricted wild type αq is strongly inhibited by YM, demonstrating that Read more at the source #DrGPCR #GPCR #IndustryNews
- N-terminal alterations turn the gut hormone GLP-2 into an antagonist with gradual loss of GLP-2 ...
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- Dopamine activates astrocytes in prefrontal cortex via α1-adrenergic receptors
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- Novel Therapies for Cardiometabolic Disease: Recent Findings in Studies with Hormone...
glucose-dependent insulinotropic polypeptide (GIP) which exert their functions through G protein-coupled receptors (GPCR Read more at the source #DrGPCR #GPCR #IndustryNews
- Design and validation of recombinant protein standards for quantitative Western blot analysis of...
antibody-antigen interaction-based approaches for quantitative analysis of G protein-coupled receptor (GPCR GPCRs in general and cannabinoid CB1 receptor in particular show a progressive tendency to aggregate This renders full-length recombinant GPCRs useless for analytical purposes, a problem that can be overcome Read more at the source #DrGPCR #GPCR #IndustryNews
- Successful prednisolone or calcimimetic treatment of acquired hypocalciuric hypercalcemia caused...
hypercalcemia caused by biased allosteric CaSR autoantibodies "Biased agonism is a frontier field in GPCR insights into the phenotype and characteristics of AHH and the mechanisms by which the biased agonism of GPCRs Read more at the source #DrGPCR #GPCR #IndustryNews
- Developing the Cannabinoid Receptor 2 (CB2) pharmacopoeia: past, present, and future
October 2022 "Cannabinoid Receptor 2 (CB2) is a G protein-coupled receptor (GPCR) with considerable, Read more at the source #DrGPCR #GPCR #IndustryNews
- The microglial endocannabinoid system similarly regulated by lipopolysaccharide and interferon gamma
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- Label-free LC-MS based assay to characterize small molecule compound binding to cells
In one example, to study a G protein coupled receptor (GPCR), we used one antagonist as probe and multiple Read more at the source #DrGPCR #GPCR #IndustryNews
- The regulation of PKA signaling in obesity and in the maintenance of metabolic health
of hormones, neurotransmitters and other signaling molecules that bind G-protein coupled receptors (GPCR Read more at the source #DrGPCR #GPCR #IndustryNews
- G protein-biased GPR3 signaling ameliorates amyloid pathology in a preclinical Alzheimer's disease..
October 2022 "Biased G protein-coupled receptor (GPCR) ligands, which preferentially activate G protein Although GPCRs are implicated in the pathophysiology of Alzheimer's disease (AD), biased GPCR signaling signaling produce discrete and separable effects and provide proof of concept for the development of safer GPCR-targeting Read more at the source #DrGPCR #GPCR #IndustryNews
- Developing the Cannabinoid Receptor 2 (CB2) pharmacopeia: past, present, and future
August 2022 "Cannabinoid Receptor 2 (CB2) is a G protein-coupled receptor (GPCR) with considerable, though Read more at the source #DrGPCR #GPCR #IndustryNews
- TRPM3 in the eye and in the nervous system - from new findings to novel mechanisms
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- Molecular insights into psychedelic drug action
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