This single point mutation in extracellular loop 2 of the β 2AR is sufficient to intrinsically bias the

The family of adhesion GPCRs called the Latrophilins or ADGRLs first captured my attention due to their Mariachi song: I typically do not sing to these since they are dear to Mexican childhood memories, and Don’t be surprised if you find yourself singing Daddy Yankee’s “Gasolina” from the top of your lungs 38421639 Systematic assessment of the tethered agonist-dependent activities of all 33 aGPCRs in a suite of transcriptional Singh

convolutional network GPCRs in Cardiology, Endocrinology, and Taste Dissecting a Brake for Airway Smooth Muscle Cell

activate specific G protein families, others are more versatile, yielding diverse responses based on cell-specific This includes proteins like AP-2 and clathrin, vital for internalization, as well as MAPK cascade kinases signaling pathways governed by β-arrestins, which exhibit increased or reduced activity within distinct cell

hedgehog pathway repression in tissue morphogenesis TIPE proteins control directed migration of human T cells

mechanism of antihistamines recognition and regulation of the histamine H1 receptor [Enhancement of mast cells

We tested effects of changes in vesicle numbers undergoing fusion at single synapses, relative placement The effects of 5-HT1B receptor-mediated inhibition are well-fit by simulated modulation of the release

Postdoctoral Fellow – Molecular Pharmacology of Feeding Behavior Director of Laboratory Operations - Single-molecule

Postdoctoral Fellow – Molecular Pharmacology of Feeding Behavior Director of Laboratory Operations - Single-molecule

Congress of Basic and Clinical Pharmacology 2026 GPCR Jobs NEW Director of Laboratory Operations - Single-molecule

In nematodes, exposure to PS-NPs (1-100 μg/L) significantly altered transcriptional expressions of some

While these structural techniques offer significant advantages in drug discovery, no single method can determine the functional consequences of every possible amino acid change at each position in a protein, as well

create large datasets regarding ligand synthesis and screening, ligand binding assays, signaling assays, cell While classical ML models are effective for datasets for which the relevant features are well understood Thomas, Smith, O’Boyle, de Graaf & Bender, 2021) and 4) limit of input data can lead to a phenomenon called

between gut microbial metabolites and GPCRome in Alzheimer's disease Methods & Updates in GPCR Research Single-chain

GPCRs are present in a range of conformations, and the binding of a ligand, as well as interactions with hand, selectivity could be achieved by merging both orthosteric and allosteric pharmacophores within a single

great versatility, with more than 50 chemokines interacting with over 20 receptors expressed on various cell CKRs structures complexes, the disulfide bridges formed between the N-loop and the β3-strand align well The active state structure of CCR2 with its endogenous agonist CCL2, as well as inactive states with

cannabis, but John Streicher , PhD, takes a closer look at the plant’s aromatic chemical compounds called

GPR110 belongs to adhesion GPCR and was the functional receptor of N-docosahexaenoyl ethanolamine (also called

Thus, we call them gluopsins.

One successful strategy is the so-called metabolic surgery whose beneficial effects are beyond dietary

COVID-19 variants, including the delta and omicron mutations, Vir CEO George Scangos said on a Dec. 7 call

Interface from Molecular Dynamics Simulations and Quantum Chemical Calculations "Allosteric modulators are called

We report that arrestin-3 modulates Fgr activity with a hallmark bell-shaped concentration-dependence

Advisory Board with appointment of immuno-oncology experts More millions roll in for Sosei Heptares Call

C. elegans secretes a family of small-molecule pheromones called ascarosides, which serve various functions

Special report 2022: Meet 20 women blazing trails in biopharma R&D ERNEST - 2022 Scientific Outputs Call

collaborations GPCR Therapeutics Announces Launch of US Phase 2 Trial of GPC-100 in Multiple Myeloma Call

Listing Rule 5635(c)(4) arcoscreen is one of the 13 biotech companies to discover in western in 2023 Call