One successful strategy is the so-called metabolic surgery whose beneficial effects are beyond dietary

COVID-19 variants, including the delta and omicron mutations, Vir CEO George Scangos said on a Dec. 7 call

Interface from Molecular Dynamics Simulations and Quantum Chemical Calculations "Allosteric modulators are called

great versatility, with more than 50 chemokines interacting with over 20 receptors expressed on various cell CKRs structures complexes, the disulfide bridges formed between the N-loop and the β3-strand align well The active state structure of CCR2 with its endogenous agonist CCL2, as well as inactive states with

Advisory Board with appointment of immuno-oncology experts More millions roll in for Sosei Heptares Call

C. elegans secretes a family of small-molecule pheromones called ascarosides, which serve various functions

Special report 2022: Meet 20 women blazing trails in biopharma R&D ERNEST - 2022 Scientific Outputs Call

collaborations GPCR Therapeutics Announces Launch of US Phase 2 Trial of GPC-100 in Multiple Myeloma Call

Listing Rule 5635(c)(4) arcoscreen is one of the 13 biotech companies to discover in western in 2023 Call

The family of adhesion GPCRs called the Latrophilins or ADGRLs first captured my attention due to their

proteins and continuously adopt different conformations based on their interactions with ligands and the cellular

GPCRs are present in a range of conformations, and the binding of a ligand, as well as interactions with phosphorylation, internalization, or desensitization), the same drug acting on the same receptor in the same cellular effects is due to different ligands inducing unique GPCR conformations that selectively activate specific cellular

potential therapeutic targets that are activated by the same endogenous ligand, create a wide diversity of cellular

October 2022 "Enzymatic and cellular signalling biosensors are used to decipher the activities of complex

mechanisms of MC3R, recent studies showed that MC3R controls growth, puberty, and circadian rhythms as well Despite the drastic effects of the MC3R deficiency in humans and other mammals, its cellular mechanisms the control of growth, puberty, and circadian rhythm, and, 3) its protein-protein interactions and cellular

GB83, initially identified as a PAR2 antagonist, is a bona fide agonist of PAR2 that induces unique cellular Our results revealed that GB83 is a bona fide agonist of PAR2 that uniquely modulates PAR2-mediated cellular

These details are often challenging to quantitatively assess yet are essential for our understanding of cellular

October 2022 "Lysosomes coordinate cellular metabolism and growth upon sensing of essential nutrients

pathology, and summarizes the ongoing and future research for targeting this critical kinase across cellular

Cellular functional studies with mutations of β1-AR residues show effects on the cellular signaling from

Although the vital role of ACs in cellular signalling is well established, the function of their transmembrane

However, cellular assays, molecular docking and site-directed mutagenesis studies have revealed that we investigated whether the impact of point mutations, already shown to have deleterious effects on cellular

pathway plays an inhibitory role in neuroinflammation, providing an opportunity to identify potential cellular

Biochemical and cellular studies show that β-arrestin1 drives tauopathy by destabilizing microtubules

processes and is dependent on activation by Ras and G protein-coupled receptors (GPCRs) to mediate its cellular

The mammalian target of rapamycin (mTOR) senses upstream stimuli to regulate numerous cellular functions Significance Statement mTORC1 is a master regulator of many cellular processes and is often hyperactivated

STATES The superfamily of G protein-coupled receptors (GPCRs) act as molecular sensors central to all cellular While GPCRs are considered a well-established field, recent technological advances to dissect the molecular

Lysophosphatidic acids (LPAs) are bioactive phospholipids implicated in a wide range of cellular activities