Search Results
362 items found for "Vivian G Oehler"
- ADGRL3 genomic variation implicated in neurogenesis and ADHD links functional effects to the...
Single nucleotide polymorphisms (SNPs) in the Adhesion G Protein-Coupled Receptor L3 (ADGRL3) gene are
- A NanoBRET-Based H 3 R Conformational Biosensor to Study Real-Time H 3 Receptor Pharmacology in...
Pharmacology in Cell Membranes and Living Cells "Conformational biosensors to monitor the activation state of G
- Nuclear localization of histamine receptor 2 in primary human lymphatic endothelial cells
In this work, we report the subcellular localization of histamine receptor 2 (H2R), a G protein-coupled
- 📰 GPCR Weekly News, September 25 to October 1, 2023
non-nutritive sweetener sucralose increases β-arrestin signaling at the constitutively active orphan G complex neuroendocrine regulatory networks mediated by spinal cord injury-induced immunodeficiency G
- GPR84 signaling promotes intestinal mucosal inflammation via enhancing NLRP3 inflammasome activation
inflammasome activation in macrophages "The putative medium-chain free fatty acid receptor GPR84 is a G
- Statin-induced increase in actin polymerization modulates GPCR dynamics and compartmentalization
actin cytoskeleton in regulating the dynamics of the serotonin1A receptor, a crucial neurotransmitter G
- Identification and functional characterization of the sulfakinin and sulfakinin receptor in the...
variety of behavioral processes and physiological functions in invertebrates through the interaction with G-protein-coupled
- Lysine 101 in the CRAC Motif in Transmembrane Helix 2 Confers Cholesterol-Induced Thermal...
in Transmembrane Helix 2 Confers Cholesterol-Induced Thermal Stability to the Serotonin 1A Receptor "G
- 📰 GPCR Weekly News, March 20 to 26, 2023
Loss of biased signaling at a G protein-coupled receptor in overexpressed systems. Methods & Updates in GPCR Research The application of targeted protein degradation technologies to G
- Sosei Heptares Enters Antibody Discovery Agreement with Twist Bioscience to Discover and Develop ...
its silicon platform, announced a strategic collaboration to discover therapeutic antibodies against G
- 📰 GPCR Weekly News, May 8 to 14, 2023
GPCR Activation and Signaling Ligand-induced activation and G protein coupling of prostaglandin F2α receptor GPCRs in Oncology and Immunology DANGER Signals Activate G-Protein Receptor Kinases Suppressing Neutrophil
- Precise druggability of the PTH type 1 receptor
Class B G protein-coupled receptors (GPCRs) are notoriously difficult to target by small molecules because
- 📰 GPCR Weekly News, July 31 to August 6, 2023
dynamic simulations Kinetic insights into agonist-dependent signalling bias at the pro-inflammatory G-protein Septerna: $150 Million Raised To Discover And Advance Novel Oral Small Molecule Medicines Targeting G
- A Chemical Biology Toolbox Targeting the Intracellular Binding Site of CCR9: Fluorescent Ligands ...
A conserved intracellular allosteric binding site (IABS) has recently been identified at several G protein-coupled
- 📰 GPCR Weekly News, January 8 to 14, 2024
synaptic modulation by α2-adrenergic receptors in auditory neurons GPCRs in Oncology and Immunology G and Exhibition June 2 - 7, 2024 | Chemotactic Cytokines June 9 - 14, 2024 | 2024 Phosphorylation and G-Protein
- Identification of A2BAR as a potential target in colorectal cancer using novel fluorescent GPCR...
Identification of A2BAR as a potential target in colorectal cancer using novel fluorescent GPCR ligands "G-protein
- Recurrent hypoglycemia increases hepatic gluconeogenesis without affecting glycogen metabolism or sy
rodent model of 3-day recurrent hypoglycemia, we first checked expression of counterregulatory hormone G-protein
- Anosmin 1 N-terminal domains modulate prokineticin receptor 2 activation by prokineticin 2
Prokineticins (PKs) exert their biological functions through the activation of the G protein-coupled
- Gαs and Gαq/11 protein coupling bias of two AVPR2 mutants (R68W and V162A) that cause nephrogenic di
AVPR2 is a kind of G protein coupled receptor (GPCR) and mainly couples with Gαs protein leading to cAMP
- PAR-Induced Harnessing of EZH2 to β-Catenin: Implications for Colorectal Cancer
September 2022 "G-protein-coupled receptors (GPCRs) are involved in a wide array of physiological and
- Combined docking and machine learning identify key molecular determinants of ligand pharmacological
September 2022 "G protein‐coupled receptors (GPCRs) are valuable therapeutic targets for many diseases
- GPCR voltage dependence controls neuronal plasticity and behavior
G-protein coupled receptors (GPCRs) play a paramount role in diverse brain functions.
- APEX2/AUR Biosensor: A Powerful Tool for Protein Interaction and Trafficking
Significant advancements in the cellular biology of G protein-coupled receptors (GPCRs) about a novel
- Biphasic activation of β-arrestin 1 upon interaction with a GPCR revealed by methyl-TROSY NMR
β-arrestins (βarrs) play multifaceted roles in the function of G protein-coupled receptors (GPCRs). βarrs
- 📰 GPCR Weekly News, February 27 to March 5, 2023
Elucidation of a dynamic interplay between a beta-2 adrenergic receptor, its agonist, and stimulatory G Developing novel antifungals: lessons from G protein-coupled receptors.
- Structure-Based Discovery of Negative Allosteric Modulators of the Metabotropic Glutamate Receptor 5
November 2022 "Recently determined structures of class C G protein-coupled receptors (GPCRs) revealed
- Applications of Cryo-EM in small molecule and biologics drug design
X-ray crystallography, by cryo-EM has enabled insights into important drug target families such as G
- Pharmacological targeting of cGAS/STING-YAP axis suppresses pathological angiogenesis and...
Pharmacological targeting of cGAS/STING-YAP signaling by both a small-molecule STING agonist, SR-717, and a G