Search Results
355 items found for "Ya-Tzu Li"
- Exploiting Dependence of Castration-Resistant Prostate Cancer on the Arginine Vasopressin ...
Furthermore, we found that castration-resistant cells produced AVP, the endogenous ligand for arginine
- Interacting binding insights and conformational consequences of the differential activity of...
dual contrasting functional feature of CBD, that is, displaying antagonistic and (possible) agonistic ligand From microsecond-length unbiased molecular dynamics simulations, we found that the presence of the CBD ligand contrast, when the GPR55 receptor is simulated in complex with the selective agonist ML186, agonist-like These results are in agreement with the proposed modulatory function of each ligand, showing that the The all-atom MD simulations reveal that CBD induces conformational changes linked with agonist-bound
- Isoforms of GPR35 have distinct extracellular N-termini that allosterically modify...
Additionally, we employed optical assays in living cells to thoroughly profile both GPR35 isoforms for constitutive and ligand-induced activation and signaling of 10 different heterotrimeric G proteins, ligand-induced arrestin recruitment, and receptor internalization. Our results reveal that the extended N-terminus of the long isoform limits G protein activation yet elevates and mechanistic insights of our study provide clues for the future design of isoform-specific GPR35 ligands
- GASP1 enhances malignant phenotypes of breast cancer cells and decreases their response to...
Mechanistically, GASP1 inhibited proteasomal degradation of insulin-like growth factor 1 receptor (IGF1R ) by competitively binding to IGF1R with ubiquitin E3 ligase MDM2, thereby activating its downstream
- Primary cilia and SHH signaling impairments in human and mouse models of Parkinson’s disease
ciliary dysfunction may be required for the development of pathoetiological phenotypes observed in sPD like
- Biased GPCR signaling by the native parathyroid hormone-related protein 1 to 141 relative to its...
transient cAMP production, acute intracellular Ca2+ (iCa2+) release and β-arrestin recruitment mediated by ligand-PTHR
- PAR-Induced Harnessing of EZH2 to β-Catenin: Implications for Colorectal Cancer
correlated with high PAR4-driven tumors, and is abundantly expressed in large tumors, whereas very little
- Sweet taste receptor agonists attenuate macrophage IL‐1β expression and eosinophilic inflammation...
2022 Sweet taste receptor agonists attenuate macrophage IL‐1β expression and eosinophilic inflammation linked
- Opposite Effects of Src Family Kinases on YAP and ERK Activation in Pancreatic Cancer Cells...
As therapeutic options are limited, novel targets and agents for therapeutic intervention are urgently
- CD28 and chemokine receptors: Signalling amplifiers at the immunological synapse
During years, several studies have depicted the pivotal role of the cytoskeleton and lipid microdomains
- Immunomodulatory Role of Neuropeptides in the Cornea
regarding the details of neuropeptide signaling and how it contributes to pathophysiology, which is likely of corneal diseases with promising results, necessitating the need for a comprehensive review of the literature
- C3aR plays both sides in regulating resistance to bacterial infections
In light of these new results, it is imperative that we revisit previous studies regarding the role of
- Targeting mGluR2/3 for treatment of neurodegenerative and neuropsychiatric diseases
then highlight the evidence supporting the use of various drugs including orthosteric and allosteric ligands
- Functional Characterization of the Venus Flytrap Domain of the Human TAS1R2 Sweet Taste Receptor
of class C GPCRs whose members share the same architecture, comprising a Venus Flytrap (VFT) module linked Using size-exclusion chromatography coupled with light scattering, we found that hTAS1R2-VFT behaves Ligand binding quantified by intrinsic tryptophan fluorescence showed that hTAS1R2-VFT is capable of have deleterious effects on cellular assays, could impact the ability of hTAS1R2-VFT to bind sweet ligands As expected, the ligand affinities of hTAS1R2-VFT were drastically reduced through the introduction of
- Dynamic recognition of naloxone, morphine and endomorphin1 in the same pocket of µ-opioid receptors
metadynamics-enhanced conformational sampling are used here to determine the different interactions of these two ligands The endogenous peptide ligand endomorphin-1 (EM-1) underwent almost no significant conformational changes This finding reveals a dynamic mechanism for the response of MOR to different ligands and provides a basis for the discovery of new ligands for MOR at the atomic level."
- The Bile Acid Membrane Receptor TGR5 in Cancer: Friend or Foe?
TGR5 is widely distributed in the brain, lung, heart, liver, spleen, pancreas, kidney, stomach, jejunum
- Trainees, this is for you...
Would you like to develop your presentation skills? Give a talk or present a poster at the Dr.
- Carola Weiss joins InterAx Biotech AG as VP Business Development
Carola Weiss ’ professional career brings deep expertise in business development, marketing & sales, licensing
- Exscientia and Sanofi Establish Strategic Research Collaboration to Develop AI-driven Pipeline ...
England & BOSTON-- Sanofi and Exscientia announced today a groundbreaking research collaboration and license The companies have been working together since 2016 and in 2019, Sanofi in-licensed Exscientia ’s novel
- Neurocrine Biosciences Announces Positive Phase 3 Data for KINECT-HD Study Evaluating Valbenazine...
DIEGO, Dec. 7, 2021 /PRNewswire/ -- Neurocrine Biosciences (Nasdaq: NBIX) today announced positive top-line
- ChemoCentryx Announces EU Approval of TAVNEOS® (avacopan) for the Treatment of ANCA-Associated ...
receive marketing authorization in all member states of the European Union, as well as in Iceland, Liechtenstein
- 8th RSC / SCI symposium on GPCRs in Medicinal Chemistry. October 5-7, 2022, Verona, Italy
Wednesday-Friday, 5th-7th October 2022 Place Evotec Campus Levi-Montalcini, Verona, Italy Downloads and Links
- Murine bone marrow macrophages and human monocytes do not express atypical chemokine receptor 1
Erythrocytes are terminally differentiated anuclear cells with no transcription and limited translation Accordingly, within the erythroid lineage ACKR1 expression occurs first and is the highest in erythroblasts venular endothelial cells (ECs) ( Pruenster et al., 2009 ; Thiriot et al., 2017 ), including those lining macrophages, but not erythroblasts and ECs, suggesting that macrophage ACKR1 engages its non-cognate ligand In light of the extensive literature, these findings have been particularly provocative, as this was
- Karuna Therapeutics Announces Positive Results from Phase 3 EMERGENT-2 Trial of KarXT in...
clinical-stage biopharmaceutical company driven to create and deliver transformative medicines for people living
- Anatomy of a partnership: Cancer Research UK teams up with Sosei Heptares
Cancer Research UK , a charity dedicated to funding lifesaving oncology research, spent £388 million
- Pharmacophore-guided Virtual Screening to Identify New β 3 -adrenergic Receptor Agonists
It is a therapeutic target because it plays a role in thermogenesis, lipolysis, and bladder relaxation Ligand-based pharmacophore modeling was performed since no 3D structure of human β3 -AR is yet available
- 4GPCRnet, September 26-29, 2022. Leipzig, Germany
will take place in the heart of Leipzig, which offers a colorful mixture of culture and vivid social life
- Crinetics Presents Clinical And Research Results At ENDO 2022
serum cortisol levels and 24-hour urine free cortisol excretion in the presence of sustained, disease-like