cannabis, but John Streicher , PhD, takes a closer look at the plant’s aromatic chemical compounds called

GPR110 belongs to adhesion GPCR and was the functional receptor of N-docosahexaenoyl ethanolamine (also called

Thus, we call them gluopsins.

One successful strategy is the so-called metabolic surgery whose beneficial effects are beyond dietary

COVID-19 variants, including the delta and omicron mutations, Vir CEO George Scangos said on a Dec. 7 call

Interface from Molecular Dynamics Simulations and Quantum Chemical Calculations "Allosteric modulators are called

C. elegans secretes a family of small-molecule pheromones called ascarosides, which serve various functions

collaborations GPCR Therapeutics Announces Launch of US Phase 2 Trial of GPC-100 in Multiple Myeloma Call

Listing Rule 5635(c)(4) arcoscreen is one of the 13 biotech companies to discover in western in 2023 Call

The family of adhesion GPCRs called the Latrophilins or ADGRLs first captured my attention due to their

be identified by Robert Lefkowitz and colleagues during their study of the effects of adrenaline on cells2

GPCRs are present in a range of conformations, and the binding of a ligand, as well as interactions with phosphorylation, internalization, or desensitization), the same drug acting on the same receptor in the same cellular effects is due to different ligands inducing unique GPCR conformations that selectively activate specific cellular

potential therapeutic targets that are activated by the same endogenous ligand, create a wide diversity of cellular

October 2022 "Enzymatic and cellular signalling biosensors are used to decipher the activities of complex

GB83, initially identified as a PAR2 antagonist, is a bona fide agonist of PAR2 that induces unique cellular Our results revealed that GB83 is a bona fide agonist of PAR2 that uniquely modulates PAR2-mediated cellular

October 2022 "Lysosomes coordinate cellular metabolism and growth upon sensing of essential nutrients

These details are often challenging to quantitatively assess yet are essential for our understanding of cellular

mechanisms of MC3R, recent studies showed that MC3R controls growth, puberty, and circadian rhythms as well Despite the drastic effects of the MC3R deficiency in humans and other mammals, its cellular mechanisms the control of growth, puberty, and circadian rhythm, and, 3) its protein-protein interactions and cellular

pathology, and summarizes the ongoing and future research for targeting this critical kinase across cellular

Cellular functional studies with mutations of β1-AR residues show effects on the cellular signaling from

Although the vital role of ACs in cellular signalling is well established, the function of their transmembrane

However, cellular assays, molecular docking and site-directed mutagenesis studies have revealed that we investigated whether the impact of point mutations, already shown to have deleterious effects on cellular

pathway plays an inhibitory role in neuroinflammation, providing an opportunity to identify potential cellular

Biochemical and cellular studies show that β-arrestin1 drives tauopathy by destabilizing microtubules

Lysophosphatidic acids (LPAs) are bioactive phospholipids implicated in a wide range of cellular activities

The mammalian target of rapamycin (mTOR) senses upstream stimuli to regulate numerous cellular functions Significance Statement mTORC1 is a master regulator of many cellular processes and is often hyperactivated

STATES The superfamily of G protein-coupled receptors (GPCRs) act as molecular sensors central to all cellular While GPCRs are considered a well-established field, recent technological advances to dissect the molecular