The mammalian target of rapamycin (mTOR) senses upstream stimuli to regulate numerous cellular functions Understanding the upstream regulators of mTORC1 will provide a crucial link to targeting mTORC1 hyperactivated In this review, we will discuss the regulation of mTORC1 by upstream stimuli, with a specific focus on G-protein coupled receptor (GPCR) signaling to mTORC1. Read full article

December 2021 "30/11/2021 Confo will work together with Regeneron to apply its GPCR drug discovery spin-off Confo Therapeutics today announced that it has entered into a collaborative agreement with Regeneron uses conformationally selective VHH antibodies – ConfoBodies® – to stabilize GPCRs (G protein-coupled receptors ) in disease-relevant conformations, will be applied with the goal of enabling the discovery of novel therapeutic antibody drug candidates. " Read more at the source #DrGPCR #GPCR #IndustryNews

December 2021 OMass Therapeutics 's founder, Carol Robinson , has been awarded the prestigious Louis-Jeantet Franklin Medal in Chemistry from The Franklin Institute " Huge congratulations to our founder, Carol Robinson #DrugDiscovery #MassSpec #Award #massspectrometry" Read more at the source #DrGPCR #GPCR #IndustryNews

Biotechnology , a clinical stage company unlocking the therapeutic potential of G Protein-Coupled Receptors OB-004 is a GPCR targeted protein analog of CCL2 that targets the CCR2 receptor. The CCL2/CCR2 pathway plays an important role in oncology, inflammatory, metabolic, and neurological Read more at the source #DrGPCR #GPCR #IndustryNews

Register here (FREE) https://www.ecosystem.drgpcr.com/dr-gpcr-virtual-cafe #drgpcr #gpcr #virtualcafe

Greetings readers! The workshop includes: Four x 2-hour Zoom sessions One-on-one meeting with Dr. Hoare Access to Dr. Do you want to re-watch our recorded events? May 16 - 19, 2024 | ASPET 2024 May 27 - 29, 2024 | SLAS Europe 2024 Conference and Exhibition June 2 Mediated Signaling Networks June 25 - 29, 2024 | FENS Forum 2024 October 2024 | Biologics US 2024 October 2

FSLLRY-NH2, a protease-activated receptor 2 (PAR2) antagonist, activates mas-related G protein-coupled GPCRs in Neuroscience Conformationally Selective 2-Aminotetralin Ligands Targeting the alpha2A- and alpha2C-Adrenergic Receptors. A vital role for PICK1 in the differential regulation of metabotropic glutamate receptor internalization (July 2 - 7, 2023). 3rd Annual Meeting IRN I-GPCRNet (October 25 - 27, 2023) GPCR Jobs NEW Postdoctoral

Hi readers! Their research reveals how VU0486846 reduces neurogliosis in female Alzheimer's mice. Dr. to variants impacting gene function Interaction modes of human orexin 2 receptor with selective and May 16 - 19, 2024 | ASPET 2024 May 27 - 29, 2024 | SLAS Europe 2024 Conference and Exhibition June 2 Mediated Signaling Networks June 25 - 29, 2024 | FENS Forum 2024 October 2024 | Biologics US 2024 October 2

November 2021 Positive Recommendation for Use of TAVNEOS™ (avacopan) in ANCA Vasculitis Adopted by European Medicines Agency’s (EMA) Committee for Medicinal Products for Human Use (CHMP) adopted a positive opinion recommending authorization for the Company’s TAVNEOS (avacopan), an orally administered selective complement 5a receptor inhibitor, in combination with a rituximab or cyclophosphamide regimen, indicated for the treatment Read more at the source #DrGPCR #GPCR #IndustryNews

November 2021 "So proud and grateful to receive honorary doctorate yesterday from Karolinska Institute Read more at the source #DrGPCR #GPCR #IndustryNews

As a result, most approved library-derived antibodies originate from just three libraries. The drugs also target relatively low-hanging fruit: like cytokines or tyrosine kinase receptors. To target hard-to-drug targets like G protein-coupled receptors (GPCRs), more libraries, including better Read more at the source #DrGPCR #GPCR #IndustryNews

November 2021 Read more at the source #DrGPCR #GPCR #IndustryNews

Stay tuned for more details, and be ready to register in July 2024. Dr. 2 Inverse Agonists Development of Putative Bivalent Dicovalent Ligands for the Adenosine A1 Receptor cells and boosts HIV-1 R5 replication Methods & Updates in GPCR Research Evaluation and comparison of Events, Meetings, and Webinars NEW June 1 - 4, 2024 | ENDO 2024 NEW June 3 - 6, 2024 | BIO 2024 June 2 Mediated Signaling Networks June 25 - 29, 2024 | FENS Forum 2024 October 2024 | Biologics US 2024 October 2

Platelet P2Y1 receptor exhibits constitutive G protein signaling and β-arrestin 2 recruitment. Myers Squibb In-Licensed PKC Theta Inhibitor, EXS4318 GPCR Therapeutics Announces Launch of US Phase 2 of ‘renewed interest’ Addex Strategic Partner Completes Enrollment In Adx71149 Epilepsy Phase 2 Study (March 2, 2023) GEM2023. (March 14-17, 2023). SLAS 2023 B uilding Biology in 3D Symposium. (July 2 - 7, 2023).

but suppresses IL-2 production by inhibiting activation of pAKT pathways in primary T cells. G-protein-coupled receptors. Specialized Pro-resolving Lipid Mediators and Resolution of Viral Diseases. (July 2 - 7, 2023). 3rd Annual Meeting IRN I-GPCRNet (October 25 - 27, 2023) GPCR Retreat (November 2 - 4, 2023) Registration

Howard Rockman, and Dr.  Bicarbonate signalling via G protein-coupled receptor regulates ischaemia-reperfusion injury GPCRs in 2 (VIPR2) signaling suppresses cyclin D1-dependent cell-cycle progression in MCF-7 cells Methods & Updates May 16 - 19, 2024 | ASPET 2024 May 27 - 29, 2024 | SLAS Europe 2024 Conference and Exhibition June 2 Mediated Signaling Networks June 25 - 29, 2024 | FENS Forum 2024 October 2024 | Biologics US 2024 October 2

We've refreshed the schedule and can’t wait for you to join us on these new dates. We highly recommend exploring valuable resources such as ' Applying Pharmacology to Drug Discovery ' Site and CNS Drug Innovation Forum Nxera Pharma Notes Positive Phase 2 Data for Partnered Schizophrenia September 30 - October 3, 2024 | 22nd Discovery on Target October 2024 | Biologics US 2024   October 2 or Lead Researcher   Become a Premium Member!

Don't miss the 3rd ECI GPCR 2-day symposium organized by and for early career investigators (ECIs) exploring The GPCR Retreat is coming up November 2-4! We're proud sponsors of this historic event. Early-bird registration and abstract submissions close on September 8, and final registration ends on of the glucagon receptor is dynamic Ligand recognition and G protein coupling of the human itch receptor (November 2 - 4, 2023) MPGPCR Conference (November 15 -17, 2023) ASCEPT Annual Scientific Meeting (November

Ines Liebscher, Ross Cheloha and Silvio Gutkind. The G protein-coupled receptor neuropeptide receptor-15 modulates larval development via the transforming activation of the medium-chain fatty acid-sensing receptor GPR84. EyeBio Announces First Patients Dosed in Phase 1b/2 Trial of Restoret™ in Neovascular Age Related Macular (July 2 - 7, 2023). 3rd Annual Meeting IRN I-GPCRNet (October 25 - 27, 2023) GPCR Retreat (November 2

Adolescent Patients with Classic Congenital Adrenal Hyperplasia at ENDO 2022 "06/13/22 - Substantial Reductions Studies Currently Underway in Pediatric (2–17 years of age) and Adult (18 years of age and older) Patients (Nasdaq: NBIX) today announced that it will present new Phase 2 data on the use of crinecerfont in adolescent These data will be shared as an oral presentation by Ron S. Read more at the source #DrGPCR #GPCR #IndustryNews

Hi readers! Dive into our GPCR coverage for this week! Kathleen M Caron and her team studied the GPER/GPR30 complex with β1-adrenergic receptor and AKAP5 in therapeutic potential in neurodegenerative diseases The progress of small molecules against cannabinoid 2 May 16 - 19, 2024 | ASPET 2024 May 27 - 29, 2024 | SLAS Europe 2024 Conference and Exhibition June 2 Phosphorylation and G-Protein Mediated Signaling Networks June 25 - 29, 2024 | FENS Forum 2024 October 2

Hello readers! The newest GPCR research is hot off the press! We’ve curated 18 GPCR papers, 8 industry news, and 2 GPCR job offers! and regulation of the histamine H1 receptor [Enhancement of mast cells activation by ATP via P2X4 receptor May 16 - 19, 2024 | ASPET 2024 May 27 - 29, 2024 | SLAS Europe 2024 Conference and Exhibition June 2 Phosphorylation and G-Protein Mediated Signaling Networks June 25 - 29, 2024 | FENS Forum 2024 October 2

Good day readers! Matthew T Eddy and his team's research on A2A adenosine receptor activation by G protein and mutations 2 and 3 as cancer biomarkers beyond NET: a paired immunohistochemistry approach The combination of brentuximab May 16 - 19, 2024 | ASPET 2024 May 27 - 29, 2024 | SLAS Europe 2024 Conference and Exhibition June 2 Phosphorylation and G-Protein Mediated Signaling Networks NEW June 25 - 29, 2024 | FENS Forum 2024 October 2

GPCRs in Neuroscience Heterotrimeric G proteins regulate planarian regeneration and behavior. Methods & Updates in GPCR Research Engineered Human Antibody with Improved Endothelin Receptor Type A in ADX71149 Epilepsy Phase 2 Study Part 1 IPO Raises $161M for GPCR-Based Drug Developer Structure Therapeutics (March 2, 2023) GEM2023. (March 14-17, 2023). SLAS 2023 B Building Biology in 3D Symposium. (July 2 - 7, 2023).

Did you register for our next Dr. GPCR Virtual Cafe? Register today! Addgene's Dr. If you need a plasmid for your research or you want to share your materials, this is the place to go.

Our Students Highly Recommend Us! Our goal is to ensure that education is within reach for everyone! for New Therapeutic Options 📍  Boston, MA 📅 October 2 -3, 2024 Join leading scientists to investigate 2 (OX2R) Agonist, ORX750, in Acutely Sleep-Deprived Healthy Volunteers Cumulus raising $50M, spinning September 30 - October 3, 2024 | 22nd Discovery on Target October 2024 | Biologics US 2024   October 2

Graeme Milligan for receiving the Order of British Empire from King Charles III in recognition of his The G protein-coupled receptor GPRC5C is a saccharide sensor with a novel "off" response. GPCRs in Oncology and Immunology Minireview: functional roles of tissue kallikrein, kinins, and kallikrein-related First Patient Enrolled in Phase 1/2 “ELUCIDATE” Trial Assessing GTAEXS617 in Advanced Solid Tumours A 3rd Annual Meeting IRN I-GPCRNet (October 25 - 27, 2023) GPCR Retreat (November 2 - 4, 2023) Registration

Hello Readers👋, GPCR weekly newsletter is here! Elucidation of a dynamic interplay between a beta-2 adrenergic receptor, its agonist, and stimulatory Reviews, GPCRs, and more Short-chain fatty acids: possible regulators of insulin secretion. Function and structure of bradykinin receptor 2 for drug discovery. (July 2 - 7, 2023). 3rd Annual Meeting IRN I-GPCRNet (October 25 - 27, 2023) GPCR Jobs PhD candidate