Search Results
494 items found for "Bcl-2"
- Diversity and specificity in location-based signaling outputs of neuronal GPCRs
August 2022 "The common mechanisms by which members of the G protein-coupled receptor (GPCR) family respond
- Deciphering the signaling mechanisms of β-arrestin1 and β-arrestin2 in regulation of cancer cell...
August 2022 Deciphering the signaling mechanisms of β-arrestin1 and β-arrestin2 in regulation of cancer
- Structural basis of GPCR coupling to distinct signal transducers: implications for biased signaling
August 2022 "Three classes of G-protein-coupled receptor (GPCR) partners - G proteins, GPCR kinases,
- Synthesis and characterization of an orally bioavailable small molecule agonist of the apelin recept
August 2022 "The apelin receptor (APJ) is a target for cardiovascular indications. pyrazole-based agonist 1 ((S)-N-(1-(cyclobutylamino)-1-oxo-5-(piperidin-1-yl)pentan-3-yl)-1-cyclopentyl-5-(2,6 Orally bioavailable compound 47 with favorable agonist potency (Ca2+EC50 = 24 nM, cAMPi EC50 = 6.5 nM ) and pharmacokinetic properties (clearance ∼20 mL/min/kg in rats) was identified.
- Exploring pharmacological inhibition of G q/11 as an analgesic strategy
August 2022 "Background and purpose: Misuse of opioids has greatly affected our society. study was to test this hypothesis pharmacologically by using potent and selective Gq/11 inhibitor YM-254890 assays to evaluate the acute responses of mice to painful thermal stimulation while administering YM-254890 We then used electrophysiological recordings to evaluate the effects of YM-254890 on the excitability
- A NanoBRET-Based H 3 R Conformational Biosensor to Study Real-Time H 3 Receptor Pharmacology in...
August 2022 A NanoBRET-Based H 3 R Conformational Biosensor to Study Real-Time H 3 Receptor Pharmacology
- Luciferase-based GloSensor™ cAMP assay: Temperature optimization and application to cell-based kinet
August 2022 Luciferase-based GloSensor™ cAMP assay: Temperature optimization and application to cell-based cells transiently transfected with the adenosine receptor A2a and the GloSensor™ plasmid (pGloSensor-20F or -22F). As well, the GloSensor-22F biosensor had a superior signal-to-background ratio and the effect of temperature
- In vivo detection of GPCR-dependent signaling using fiber photometry and FRET-based biosensors
August 2022 "Genetically encoded fluorescent biosensors allow intracellular signaling dynamics to be
- GPR3 expression in retinal ganglion cells contributes to neuron survival and accelerates axonal...
August 2022 GPR3 expression in retinal ganglion cells contributes to neuron survival and accelerates
- Aβ peptides stabilize GPCRs in inactive form and trigger inverse agonism in Alzheimer's disease
August 2022 "Several G-protein coupled receptors (GPCR) are upregulated in Alzheimer's Disease (AD),
- The integrin ligand SVEP1 regulates GPCR-mediated vasoconstriction via integrins α9β1 and α4β1
August 2022 " Background and purpose: Vascular tone is regulated by the relative contractile state of
- GPR110, a receptor for synaptamide, expressed in osteoclasts negatively regulates osteoclastogenesis
August 2022 "Bone remodeling is precisely regulated mainly by osteoblasts and osteoclasts.
- RGS7-ATF3-Tip60 Complex Promotes Hepatic Steatosis and Fibrosis by Directly Inducing TNFα
August 2022 "Aims: The pathophysiological mechanism(s) underlying non-alcoholic fatty liver disease (
- TAS2R supports odontoblastic differentiation of human dental pulp stem cells in the inflammatory...
August 2022 TAS2R supports odontoblastic differentiation of human dental pulp stem cells in the inflammatory
- MSX-122: Is an effective small molecule CXCR4 antagonist in cancer therapy?
August 2022 "Chemokines, a subgroup of cytokines along with their receptors, are involved in various
- A correlation study of adhesion G protein-coupled receptors as potential therapeutic targets in...
August 2022 A correlation study of adhesion G protein-coupled receptors as potential therapeutic targets
- Structures of oxysterol sensor EBI2/GPR183, a key regulator of the immune response
August 2022 "Oxysterols induce the migration of B-lymphocytes and dendritic cells to interfollicular Here, we report the cryo-EM structures of an EBI2-Gi signaling complex with its endogenous agonist 7α,25
- Helix 8 in chemotactic receptors of the complement system
August 2022 "Host response to infection involves the activation of the complement system leading to the
- Tracking receptor motions at the plasma membrane reveals distinct effects of ligands on CCR5...
August 2022 "G-protein-coupled receptors (GPCR) are present at the cell surface in different conformational
- Structures of β 1-adrenergic receptor in complex with Gs and ligands of different efficacies
August 2022 "G-protein-coupled receptors (GPCRs) receive signals from ligands with different efficacies
- Fusion protein strategies for cryo-EM study of G protein-coupled receptors
August 2022 "Single particle cryogenic-electron microscopy (cryo-EM) is used extensively to determine
- Multifunctional role of GPCR signaling in epithelial tube formation
August 2022 "Epithelial tube formation requires Rho1-dependent actomyosin contractility to generate the
- Molecular basis for ligand modulation of the cannabinoid CB 1 receptor
August 2022 "The cannabinoid CB1 receptor is the most abundant G protein coupled receptor (GPCR)
- The NPXXY Motif Regulates β-Arrestin Recruitment by the CB1 Cannabinoid Receptor
August 2022 "Background: Activation of signaling effectors by G-protein coupled receptors (GPCRs) depends
- Production of human A2AAR in lipid nanodiscs for 19F-NMR and single-molecule fluorescence...
August 2022 Production of human A 2A AR in lipid nanodiscs for 19 F-NMR and single-molecule fluorescence For complete details on the use and execution of this protocol, please refer to Wei et al. (2022) and Sušac et al. (2018)."
- Dopamine D 1 receptor-mediated β-arrestin signaling: Insight from pharmacology, biology, behavior...
August 2022 Dopamine D 1 receptor-mediated β-arrestin signaling: Insight from pharmacology, biology,
- In vitro assays for the functional characterization of (psychedelic) substances at the serotonin...
August 2022 In vitro assays for the functional characterization of (psychedelic) substances at the serotonin that induce alterations in mood, perception, and thought, and have the activation of serotonin (5-HT) 2A
- Opioid Ligands Addressing Unconventional Binding Sites and More Than One Opioid Receptor Subtype
August 2022 "Opioid receptors (ORs) represent one of the most significant groups of G-protein coupled