Search Results
387 items found for "Bing Li"
- Biased GPCR signaling by the native parathyroid hormone-related protein 1 to 141 relative to its...
transient cAMP production, acute intracellular Ca2+ (iCa2+) release and β-arrestin recruitment mediated by ligand-PTHR
- PAR-Induced Harnessing of EZH2 to β-Catenin: Implications for Colorectal Cancer
correlated with high PAR4-driven tumors, and is abundantly expressed in large tumors, whereas very little
- Sweet taste receptor agonists attenuate macrophage IL‐1β expression and eosinophilic inflammation...
2022 Sweet taste receptor agonists attenuate macrophage IL‐1β expression and eosinophilic inflammation linked
- Opposite Effects of Src Family Kinases on YAP and ERK Activation in Pancreatic Cancer Cells...
As therapeutic options are limited, novel targets and agents for therapeutic intervention are urgently
- CD28 and chemokine receptors: Signalling amplifiers at the immunological synapse
During years, several studies have depicted the pivotal role of the cytoskeleton and lipid microdomains
- Immunomodulatory Role of Neuropeptides in the Cornea
regarding the details of neuropeptide signaling and how it contributes to pathophysiology, which is likely of corneal diseases with promising results, necessitating the need for a comprehensive review of the literature
- C3aR plays both sides in regulating resistance to bacterial infections
In light of these new results, it is imperative that we revisit previous studies regarding the role of
- Targeting mGluR2/3 for treatment of neurodegenerative and neuropsychiatric diseases
then highlight the evidence supporting the use of various drugs including orthosteric and allosteric ligands
- The Bile Acid Membrane Receptor TGR5 in Cancer: Friend or Foe?
TGR5 is widely distributed in the brain, lung, heart, liver, spleen, pancreas, kidney, stomach, jejunum
- Multifunctional role of GPCR signaling in epithelial tube formation
During Drosophila embryonic salivary gland (SG) invagination, the GPCR ligand Folded gastrulation (Fog Our data support a model wherein Smog regulates distinct myosin pools and actin cytoskeleton in a ligand-dependent
- Neuropeptide S Encodes Stimulus Salience in the Paraventricular Thalamus
nucleus accumbens shell and structures in the prefrontal cortex and amygdala, which were previously linked
- Delineation of GPR15 receptor-mediated Gα protein signaling profile in recombinant mammalian cell
receptor-mediated Gα protein signalling using a G protein activation assay and second messenger assay conducted on living
- Lack of Oestrogen Receptor Expression in Breast Cancer Cells Does Not Correlate with Kisspeptin...
KISS1R signalling and physiological output in the hormone receptor-negative MDA-MB-231 and BT-20 cell lines MDA-MB-231 cells are metastatic when implanted in mice while BT-20 are not and remain epithelial-like We show that both cell lines express KISS1R mRNA and respond to KP-10 by elevating calcium mobilisation Interestingly, both cell lines displayed different complements of β-arrestin 1 and 2 expression. stimulate migration or pro-metastatic behaviour, as divergent responses were observed in the two TNBC lines
- GRK3 is a poor prognosticator and serves as a therapeutic target in advanced gastric adenocarcinoma
We identified a novel GRK3 inhibitor, LD2, through a chemical-library screen.
- Chemerin Forms: Their Generation and Activity
Chemerin is produced by the liver and secreted into the circulation as a precursor, but it is also expressed
- Microbial Metabolites Orchestrate a Distinct Multi-Tiered Regulatory Network in the Intestinal Epith
Using shRNA knockdown and CRISPR/Cas9 knockout cell lines, as well as mouse models, we confirmed the These findings shed light on a sophisticated signaling network directed by intestinal microbial metabolites that orchestrate P-gp expression and highlight unappreciated connections between multiple pathways linked
- Endothelin-1 Stimulates PAI-1 Protein Expression via Dual Transactivation Pathway Dependent ROCK...
Smad2L "In addition to the carboxy region, Smad2 transcription factor can be phosphorylated in the linker Phosphorylation of Smad2 linker region (Smad2L) promotes the expression of plasminogen activator inhibitor were investigated<br />by western blotting using protein-specific antibodies against phospho-Smad2 linker
- Neurotransmitters: Potential Targets in Glioblastoma
Significantly, many ligands acting on neurotransmitter receptors have shown great potential for inhibiting
- Pharmacological Properties and Function of PxOctβ3 Octopamine Receptor in Plutella xylostella (L.)
Thus, we investigated the regulatory functions of its β-adrenergic-like octopamine receptor (PxOctβ3)
- Platelets in the NETworks interweaving inflammation and thrombosis
In light of the current COVID-19 pandemic, the topic of immunothrombosis has become more relevant than
- GPCR/endocytosis/ERK signaling/S2R is involved in the regulation of the internalization...
We also adopted live cell imaging to monitor the whole intracellular trafficking process of F-Hst1.
- Structure of Mycobacterium tuberculosis Cya, an evolutionary ancestor of the mammalian membrane...
domain and providing the means for direct regulation of catalytic activity in response to extracellular ligands
- CCL25/CCR9 interaction promotes the malignant behavior of salivary adenoid cystic carcinoma via...
CC chemokine receptor 9 (CCR9), an organ-specific chemokine receptor, interacts with its exclusive ligand
- Fentanyl activates ovarian cancer and alleviates chemotherapy-induced toxicity via opioid...
Although increasing evidence has suggested the direct role of fentanyl on cancer, little is known on
- Trainees, this is for you...
Would you like to develop your presentation skills? Give a talk or present a poster at the Dr.
- Carola Weiss joins InterAx Biotech AG as VP Business Development
Carola Weiss ’ professional career brings deep expertise in business development, marketing & sales, licensing, alliance management, and strategic partnering.
- Exscientia and Sanofi Establish Strategic Research Collaboration to Develop AI-driven Pipeline ...
England & BOSTON-- Sanofi and Exscientia announced today a groundbreaking research collaboration and license The companies have been working together since 2016 and in 2019, Sanofi in-licensed Exscientia ’s novel
- Neurocrine Biosciences Announces Positive Phase 3 Data for KINECT-HD Study Evaluating Valbenazine...
DIEGO, Dec. 7, 2021 /PRNewswire/ -- Neurocrine Biosciences (Nasdaq: NBIX) today announced positive top-line